Seasonal Dynamics of the Upper Respiratory Tract Microbiome in Chronic Obstructive Pulmonary Disease

Shuping Cai,1,2,* Jingyuan Gao,3,* Xiaomin Liu,3,* Junhao Yang,3,* Dingyun Feng,1 Guijun Li,2 Sijia Li,1 Hailing Yang,1 Zhang Wang,3 Xinzhu Yi,3 Yuqi Zhou1 1Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, the Third Affiliated Hos...

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Main Authors: Cai S, Gao J, Liu X, Yang J, Feng D, Li G, Li S, Yang H, Wang Z, Yi X, Zhou Y
Format: Article
Language:English
Published: Dove Medical Press 2023-06-01
Series:International Journal of COPD
Subjects:
Online Access:https://www.dovepress.com/seasonal-dynamics-of-the-upper-respiratory-tract-microbiome-in-chronic-peer-reviewed-fulltext-article-COPD
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author Cai S
Gao J
Liu X
Yang J
Feng D
Li G
Li S
Yang H
Wang Z
Yi X
Zhou Y
author_facet Cai S
Gao J
Liu X
Yang J
Feng D
Li G
Li S
Yang H
Wang Z
Yi X
Zhou Y
author_sort Cai S
collection DOAJ
description Shuping Cai,1,2,* Jingyuan Gao,3,* Xiaomin Liu,3,* Junhao Yang,3,* Dingyun Feng,1 Guijun Li,2 Sijia Li,1 Hailing Yang,1 Zhang Wang,3 Xinzhu Yi,3 Yuqi Zhou1 1Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guang Dong, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, the Seventh Affiliated Hospital of SUN YAT-SEN University, Shenzhen, Guang Dong, People’s Republic of China; 3Institute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, Guang Dong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinzhu Yi; Yuqi Zhou, Email labxz@hotmail.com; zhouyuqi@mail.sysu.edu.cnIntroduction: Increasing evidence suggests that seasonal changes can trigger the alternation of airway microbiome. However, the dynamics of the upper airway bacterial ecology of chronic obstructive pulmonary disease (COPD) patients across different seasons remains unclear.Methods: In this study, we present a 16S ribosomal RNA survey of the airway microbiome on 72 swab samples collected in different months (March, May, July, September, and November) in 2019 from 18 COPD patients and from six resampled patients in November in 2020.Results: Our study uncovered a dynamic airway microbiota where changes appeared to be associated with seasonal alternation in COPD patients. Twelve clusters of temporal patterns were displayed by differential and clustering analysis along the time course, systematically revealing distinct microbial taxa that prefer to grow in cool and warm seasons, respectively. Moreover, the upper airway microbiome composition was relatively stable in the same season in different years.Discussion: Given the tight association between airway microbiome and COPD disease progression, this study can provide useful information for clinically understanding the seasonal trend of disease phenotypes in COPD patients.Graphical Abstract: Keywords: chronic obstructive pulmonary disease, upper airway microbiome, seasonal variation
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spelling doaj.art-9182bcb7d43d4d34988416db33c625d22023-07-02T19:49:16ZengDove Medical PressInternational Journal of COPD1178-20052023-06-01Volume 181267127684592Seasonal Dynamics of the Upper Respiratory Tract Microbiome in Chronic Obstructive Pulmonary DiseaseCai SGao JLiu XYang JFeng DLi GLi SYang HWang ZYi XZhou YShuping Cai,1,2,* Jingyuan Gao,3,* Xiaomin Liu,3,* Junhao Yang,3,* Dingyun Feng,1 Guijun Li,2 Sijia Li,1 Hailing Yang,1 Zhang Wang,3 Xinzhu Yi,3 Yuqi Zhou1 1Department of Pulmonary and Critical Care Medicine, Institute of Respiratory Diseases, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guang Dong, People’s Republic of China; 2Department of Pulmonary and Critical Care Medicine, the Seventh Affiliated Hospital of SUN YAT-SEN University, Shenzhen, Guang Dong, People’s Republic of China; 3Institute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, Guang Dong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinzhu Yi; Yuqi Zhou, Email labxz@hotmail.com; zhouyuqi@mail.sysu.edu.cnIntroduction: Increasing evidence suggests that seasonal changes can trigger the alternation of airway microbiome. However, the dynamics of the upper airway bacterial ecology of chronic obstructive pulmonary disease (COPD) patients across different seasons remains unclear.Methods: In this study, we present a 16S ribosomal RNA survey of the airway microbiome on 72 swab samples collected in different months (March, May, July, September, and November) in 2019 from 18 COPD patients and from six resampled patients in November in 2020.Results: Our study uncovered a dynamic airway microbiota where changes appeared to be associated with seasonal alternation in COPD patients. Twelve clusters of temporal patterns were displayed by differential and clustering analysis along the time course, systematically revealing distinct microbial taxa that prefer to grow in cool and warm seasons, respectively. Moreover, the upper airway microbiome composition was relatively stable in the same season in different years.Discussion: Given the tight association between airway microbiome and COPD disease progression, this study can provide useful information for clinically understanding the seasonal trend of disease phenotypes in COPD patients.Graphical Abstract: Keywords: chronic obstructive pulmonary disease, upper airway microbiome, seasonal variationhttps://www.dovepress.com/seasonal-dynamics-of-the-upper-respiratory-tract-microbiome-in-chronic-peer-reviewed-fulltext-article-COPDchronic obstructive pulmonary diseaseupper airway microbiomeseasonal variation
spellingShingle Cai S
Gao J
Liu X
Yang J
Feng D
Li G
Li S
Yang H
Wang Z
Yi X
Zhou Y
Seasonal Dynamics of the Upper Respiratory Tract Microbiome in Chronic Obstructive Pulmonary Disease
International Journal of COPD
chronic obstructive pulmonary disease
upper airway microbiome
seasonal variation
title Seasonal Dynamics of the Upper Respiratory Tract Microbiome in Chronic Obstructive Pulmonary Disease
title_full Seasonal Dynamics of the Upper Respiratory Tract Microbiome in Chronic Obstructive Pulmonary Disease
title_fullStr Seasonal Dynamics of the Upper Respiratory Tract Microbiome in Chronic Obstructive Pulmonary Disease
title_full_unstemmed Seasonal Dynamics of the Upper Respiratory Tract Microbiome in Chronic Obstructive Pulmonary Disease
title_short Seasonal Dynamics of the Upper Respiratory Tract Microbiome in Chronic Obstructive Pulmonary Disease
title_sort seasonal dynamics of the upper respiratory tract microbiome in chronic obstructive pulmonary disease
topic chronic obstructive pulmonary disease
upper airway microbiome
seasonal variation
url https://www.dovepress.com/seasonal-dynamics-of-the-upper-respiratory-tract-microbiome-in-chronic-peer-reviewed-fulltext-article-COPD
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