Metabolomics in viral hepatitis: advances and review
Viral hepatitis is a major worldwide public health issue, affecting hundreds of millions of people and causing substantial morbidity and mortality. The majority of the worldwide burden of viral hepatitis is caused by five biologically unrelated hepatotropic viruses: hepatitis A virus (HAV), hepatiti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1189417/full |
| _version_ | 1797825471195381760 |
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| author | Jiajia Yang Dawei Wang Yuancheng Li Hongmei Wang Qiang Hu Qiang Hu Ying Wang |
| author_facet | Jiajia Yang Dawei Wang Yuancheng Li Hongmei Wang Qiang Hu Qiang Hu Ying Wang |
| author_sort | Jiajia Yang |
| collection | DOAJ |
| description | Viral hepatitis is a major worldwide public health issue, affecting hundreds of millions of people and causing substantial morbidity and mortality. The majority of the worldwide burden of viral hepatitis is caused by five biologically unrelated hepatotropic viruses: hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV). Metabolomics is an emerging technology that uses qualitative and quantitative analysis of easily accessible samples to provide information of the metabolic levels of biological systems and changes in metabolic and related regulatory pathways. Alterations in glucose, lipid, and amino acid levels are involved in glycolysis, the tricarboxylic acid cycle, the pentose phosphate pathway, and amino acid metabolism. These changes in metabolites and metabolic pathways are associated with the pathogenesis and medication mechanism of viral hepatitis and related diseases. Additionally, differential metabolites can be utilized as biomarkers for diagnosis, prognosis, and therapeutic responses. In this review, we present a thorough overview of developments in metabolomics for viral hepatitis. |
| first_indexed | 2024-03-13T10:54:31Z |
| format | Article |
| id | doaj.art-9183afb1dbc3424d91a575beb8d7ed6e |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-13T10:54:31Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-9183afb1dbc3424d91a575beb8d7ed6e2023-05-17T05:20:59ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-05-011310.3389/fcimb.2023.11894171189417Metabolomics in viral hepatitis: advances and reviewJiajia Yang0Dawei Wang1Yuancheng Li2Hongmei Wang3Qiang Hu4Qiang Hu5Ying Wang6Department of Infection Management, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Infectious Disease, The Second People’s Hospital of Yancheng City, Yancheng, ChinaInstitute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and Sexually Transmitted Infections (STIs), Nanjing, ChinaDepartment of Infection Management, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Infection Management, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Respiratory and Critical Care Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Infection Management, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, ChinaViral hepatitis is a major worldwide public health issue, affecting hundreds of millions of people and causing substantial morbidity and mortality. The majority of the worldwide burden of viral hepatitis is caused by five biologically unrelated hepatotropic viruses: hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and hepatitis E virus (HEV). Metabolomics is an emerging technology that uses qualitative and quantitative analysis of easily accessible samples to provide information of the metabolic levels of biological systems and changes in metabolic and related regulatory pathways. Alterations in glucose, lipid, and amino acid levels are involved in glycolysis, the tricarboxylic acid cycle, the pentose phosphate pathway, and amino acid metabolism. These changes in metabolites and metabolic pathways are associated with the pathogenesis and medication mechanism of viral hepatitis and related diseases. Additionally, differential metabolites can be utilized as biomarkers for diagnosis, prognosis, and therapeutic responses. In this review, we present a thorough overview of developments in metabolomics for viral hepatitis.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1189417/fullviral hepatitismetabolomicspathogenesisbiomarkerstreatment |
| spellingShingle | Jiajia Yang Dawei Wang Yuancheng Li Hongmei Wang Qiang Hu Qiang Hu Ying Wang Metabolomics in viral hepatitis: advances and review Frontiers in Cellular and Infection Microbiology viral hepatitis metabolomics pathogenesis biomarkers treatment |
| title | Metabolomics in viral hepatitis: advances and review |
| title_full | Metabolomics in viral hepatitis: advances and review |
| title_fullStr | Metabolomics in viral hepatitis: advances and review |
| title_full_unstemmed | Metabolomics in viral hepatitis: advances and review |
| title_short | Metabolomics in viral hepatitis: advances and review |
| title_sort | metabolomics in viral hepatitis advances and review |
| topic | viral hepatitis metabolomics pathogenesis biomarkers treatment |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1189417/full |
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