The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy
The host defence responses play vital roles in viral infection and are regulated by complex interactive networks. The host immune system recognizes viral pathogens through the interaction of pattern-recognition receptors (PRRs) with pathogen-associated molecular patterns (PAMPs). As a PRR mainly in...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1352479/full |
| _version_ | 1797306675632275456 |
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| author | Kunli Zhang Qiuyan Huang Qiuyan Huang Xinming Li Ziqiao Zhao Chun Hong Zeyi Sun Bo Deng Chunling Li Jianfeng Zhang Jianfeng Zhang Sutian Wang Sutian Wang |
| author_facet | Kunli Zhang Qiuyan Huang Qiuyan Huang Xinming Li Ziqiao Zhao Chun Hong Zeyi Sun Bo Deng Chunling Li Jianfeng Zhang Jianfeng Zhang Sutian Wang Sutian Wang |
| author_sort | Kunli Zhang |
| collection | DOAJ |
| description | The host defence responses play vital roles in viral infection and are regulated by complex interactive networks. The host immune system recognizes viral pathogens through the interaction of pattern-recognition receptors (PRRs) with pathogen-associated molecular patterns (PAMPs). As a PRR mainly in the cytoplasm, cyclic GMP-AMP synthase (cGAS) senses and binds virus DNA and subsequently activates stimulator of interferon genes (STING) to trigger a series of intracellular signalling cascades to defend against invading pathogenic microorganisms. Integrated omic and functional analyses identify the cGAS-STING pathway regulating various host cellular responses and controlling viral infections. Aside from its most common function in regulating inflammation and type I interferon, a growing body of evidence suggests that the cGAS-STING signalling axis is closely associated with a series of cellular responses, such as oxidative stress, autophagy, and endoplasmic reticulum stress, which have major impacts on physiological homeostasis. Interestingly, these host cellular responses play dual roles in the regulation of the cGAS-STING signalling axis and the clearance of viruses. Here, we outline recent insights into cGAS-STING in regulating type I interferon, inflammation, oxidative stress, autophagy and endoplasmic reticulum stress and discuss their interactions with viral infections. A detailed understanding of the cGAS-STING-mediated potential antiviral effects contributes to revealing the pathogenesis of certain viruses and sheds light on effective solutions for antiviral therapy. |
| first_indexed | 2024-03-08T00:45:19Z |
| format | Article |
| id | doaj.art-918558579e7c481ab4cf2af3e3e05866 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T00:45:19Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-918558579e7c481ab4cf2af3e3e058662024-02-15T11:32:31ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.13524791352479The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagyKunli Zhang0Qiuyan Huang1Qiuyan Huang2Xinming Li3Ziqiao Zhao4Chun Hong5Zeyi Sun6Bo Deng7Chunling Li8Jianfeng Zhang9Jianfeng Zhang10Sutian Wang11Sutian Wang12State Key Laboratory of Swine and Poultry Breeding Industry, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Key Laboratory of Livestock Disease Prevention of Guangdong Province, Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou, ChinaState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaCollege of Animal Science and Technology, Guangxi University, Nanning, ChinaState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaState Key Laboratory of Swine and Poultry Breeding Industry, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Key Laboratory of Livestock Disease Prevention of Guangdong Province, Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou, ChinaState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaState Key Laboratory of Swine and Poultry Breeding Industry, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Key Laboratory of Livestock Disease Prevention of Guangdong Province, Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou, ChinaDivision of Nephrology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaState Key Laboratory of Swine and Poultry Breeding Industry, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Key Laboratory of Livestock Disease Prevention of Guangdong Province, Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou, ChinaState Key Laboratory of Swine and Poultry Breeding Industry, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Key Laboratory of Livestock Disease Prevention of Guangdong Province, Scientific Observation and Experiment Station of Veterinary Drugs and Diagnostic Techniques of Guangdong Province, Ministry of Agriculture and Rural Affairs, Guangzhou, ChinaMaoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Maoming, ChinaState Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, ChinaMaoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Maoming, ChinaThe host defence responses play vital roles in viral infection and are regulated by complex interactive networks. The host immune system recognizes viral pathogens through the interaction of pattern-recognition receptors (PRRs) with pathogen-associated molecular patterns (PAMPs). As a PRR mainly in the cytoplasm, cyclic GMP-AMP synthase (cGAS) senses and binds virus DNA and subsequently activates stimulator of interferon genes (STING) to trigger a series of intracellular signalling cascades to defend against invading pathogenic microorganisms. Integrated omic and functional analyses identify the cGAS-STING pathway regulating various host cellular responses and controlling viral infections. Aside from its most common function in regulating inflammation and type I interferon, a growing body of evidence suggests that the cGAS-STING signalling axis is closely associated with a series of cellular responses, such as oxidative stress, autophagy, and endoplasmic reticulum stress, which have major impacts on physiological homeostasis. Interestingly, these host cellular responses play dual roles in the regulation of the cGAS-STING signalling axis and the clearance of viruses. Here, we outline recent insights into cGAS-STING in regulating type I interferon, inflammation, oxidative stress, autophagy and endoplasmic reticulum stress and discuss their interactions with viral infections. A detailed understanding of the cGAS-STING-mediated potential antiviral effects contributes to revealing the pathogenesis of certain viruses and sheds light on effective solutions for antiviral therapy.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1352479/fullcGAS-STINGviral infectioninnate immuneautophagyinflammationoxidative stress |
| spellingShingle | Kunli Zhang Qiuyan Huang Qiuyan Huang Xinming Li Ziqiao Zhao Chun Hong Zeyi Sun Bo Deng Chunling Li Jianfeng Zhang Jianfeng Zhang Sutian Wang Sutian Wang The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy Frontiers in Immunology cGAS-STING viral infection innate immune autophagy inflammation oxidative stress |
| title | The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy |
| title_full | The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy |
| title_fullStr | The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy |
| title_full_unstemmed | The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy |
| title_short | The cGAS-STING pathway in viral infections: a promising link between inflammation, oxidative stress and autophagy |
| title_sort | cgas sting pathway in viral infections a promising link between inflammation oxidative stress and autophagy |
| topic | cGAS-STING viral infection innate immune autophagy inflammation oxidative stress |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1352479/full |
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