The Genetic and Molecular Analyses of <i>RAD51C</i> and <i>RAD51D</i> Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique Population

The Genetic and Molecular Analyses of <i>RAD51C</i> and <i>RAD51D</i> Identifies Rare Variants Implicated in Hereditary Ovarian Cancer from a Genetically Unique Population

To identify candidate variants in <i>RAD51C</i> and <i>RAD51D</i> ovarian cancer (OC) predisposing genes by investigating French Canadians (FC) exhibiting unique genetic architecture. Candidates were identified by whole exome sequencing analysis of 17 OC families and 53 early...

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Bibliographic Details
Main Authors: Wejdan M. Alenezi, Larissa Milano, Caitlin T. Fierheller, Corinne Serruya, Timothée Revil, Kathleen K. Oros, Supriya Behl, Suzanna L. Arcand, Porangana Nayar, Dan Spiegelman, Simon Gravel, Anne-Marie Mes-Masson, Diane Provencher, William D. Foulkes, Zaki El Haffaf, Guy Rouleau, Luigi Bouchard, Celia M. T. Greenwood, Jean-Yves Masson, Jiannis Ragoussis, Patricia N. Tonin
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cancers
Subjects:
<i>RAD51C</i>
<i>RAD51D</i>
ovarian cancer predisposing genes
French Canadian
genetic drift
Online Access:https://www.mdpi.com/2072-6694/14/9/2251

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