Determination of aortic stiffness using 4D flow cardiovascular magnetic resonance - a population-based study
Abstract Background Increased aortic stiffness is an independent predictor of cardiovascular disease. Optimal measurement is highly beneficial for the detection of atherosclerosis and the management of patients at risk. Thus, it was our purpose to selectively measure aortic stiffness using a novel i...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-06-01
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| Series: | Journal of Cardiovascular Magnetic Resonance |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12968-018-0461-z |
| _version_ | 1797203717324275712 |
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| author | Andreas Harloff Hanieh Mirzaee Thomas Lodemann Paul Hagenlocher Thomas Wehrum Judith Stuplich Anja Hennemuth Jürgen Hennig Sebastian Grundmann Werner Vach |
| author_facet | Andreas Harloff Hanieh Mirzaee Thomas Lodemann Paul Hagenlocher Thomas Wehrum Judith Stuplich Anja Hennemuth Jürgen Hennig Sebastian Grundmann Werner Vach |
| author_sort | Andreas Harloff |
| collection | DOAJ |
| description | Abstract Background Increased aortic stiffness is an independent predictor of cardiovascular disease. Optimal measurement is highly beneficial for the detection of atherosclerosis and the management of patients at risk. Thus, it was our purpose to selectively measure aortic stiffness using a novel imaging method and to provide reference values from a population-based study. Methods One hundred twenty six inhabitants of Freiburg, Germany, between 20 and 80 years prospectively underwent 3 Tesla cardiovascular magnetic resonance (CMR) of the thoracic aorta. 4D flow CMR (spatial/temporal resolution 2mm3/20ms) was executed to calculate aortic pulse wave velocity (PWV) in m/s using dedicated software. In addition, we calculated distensibility coefficients (DC) using 2D CINE CMR imaging of the ascending (AAo) and descending aorta (DAo). Segmental aortic diameter and thickness of aortic plaques were determined by 3D T1 weighted CMR (spatial resolution 1mm3). Results PWV increased from 4.93 ± 0.54 m/s in 20–30 year-old to 8.06 ± 1.03 m/s in 70–80 year-old subjects. PWV was significantly lower in women compared to men (p < 0.0001). Increased blood pressure (systolic r = 0.36, p < 0.0001; diastolic r = 0.33, p = 0.0001; mean arterial pressure r = 0.37, p < 0.0001) correlated with PWV after adjustment for age and gender. Finally, PWV increased with increasing diameter of the aorta (ascending aorta r = 0.20, p = 0.026; aortic arch r = 0.24, p = 0.009; descending aorta r = 0.26, p = 0.004). Correlation of PWV and DC of the AAo and DAo or the mean of both was high (r = 0.69, r = 0.68, r = 0.73; p < 0.001). Conclusions 4D flow CMR was successfully applied to calculate aortic PWV and thus aortic stiffness. Findings showed a high correlation with distensibility coefficients representing local compliance of the aorta. Our novel method and reference data for PWV may provide a reliable biomarker for the identification of patients with underlying cardiovascular disease and optimal guidance of future treatment in studies or clinical routine. |
| first_indexed | 2024-04-24T08:23:46Z |
| format | Article |
| id | doaj.art-9189bebd23a9427db3ba3bb852fb9bfe |
| institution | Directory Open Access Journal |
| issn | 1532-429X |
| language | English |
| last_indexed | 2024-04-24T08:23:46Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Cardiovascular Magnetic Resonance |
| spelling | doaj.art-9189bebd23a9427db3ba3bb852fb9bfe2024-04-16T23:48:10ZengElsevierJournal of Cardiovascular Magnetic Resonance1532-429X2018-06-0120111110.1186/s12968-018-0461-zDetermination of aortic stiffness using 4D flow cardiovascular magnetic resonance - a population-based studyAndreas Harloff0Hanieh Mirzaee1Thomas Lodemann2Paul Hagenlocher3Thomas Wehrum4Judith Stuplich5Anja Hennemuth6Jürgen Hennig7Sebastian Grundmann8Werner Vach9Department of Neurology, Medical Center – University of FreiburgFraunhofer MEVISDepartment of Neurology, Medical Center – University of FreiburgDepartment of Neurology, Medical Center – University of FreiburgDepartment of Neurology, Medical Center – University of FreiburgFaculty of Medicine, University of FreiburgFraunhofer MEVISFaculty of Medicine, University of FreiburgFaculty of Medicine, University of FreiburgFaculty of Medicine, University of FreiburgAbstract Background Increased aortic stiffness is an independent predictor of cardiovascular disease. Optimal measurement is highly beneficial for the detection of atherosclerosis and the management of patients at risk. Thus, it was our purpose to selectively measure aortic stiffness using a novel imaging method and to provide reference values from a population-based study. Methods One hundred twenty six inhabitants of Freiburg, Germany, between 20 and 80 years prospectively underwent 3 Tesla cardiovascular magnetic resonance (CMR) of the thoracic aorta. 4D flow CMR (spatial/temporal resolution 2mm3/20ms) was executed to calculate aortic pulse wave velocity (PWV) in m/s using dedicated software. In addition, we calculated distensibility coefficients (DC) using 2D CINE CMR imaging of the ascending (AAo) and descending aorta (DAo). Segmental aortic diameter and thickness of aortic plaques were determined by 3D T1 weighted CMR (spatial resolution 1mm3). Results PWV increased from 4.93 ± 0.54 m/s in 20–30 year-old to 8.06 ± 1.03 m/s in 70–80 year-old subjects. PWV was significantly lower in women compared to men (p < 0.0001). Increased blood pressure (systolic r = 0.36, p < 0.0001; diastolic r = 0.33, p = 0.0001; mean arterial pressure r = 0.37, p < 0.0001) correlated with PWV after adjustment for age and gender. Finally, PWV increased with increasing diameter of the aorta (ascending aorta r = 0.20, p = 0.026; aortic arch r = 0.24, p = 0.009; descending aorta r = 0.26, p = 0.004). Correlation of PWV and DC of the AAo and DAo or the mean of both was high (r = 0.69, r = 0.68, r = 0.73; p < 0.001). Conclusions 4D flow CMR was successfully applied to calculate aortic PWV and thus aortic stiffness. Findings showed a high correlation with distensibility coefficients representing local compliance of the aorta. Our novel method and reference data for PWV may provide a reliable biomarker for the identification of patients with underlying cardiovascular disease and optimal guidance of future treatment in studies or clinical routine.http://link.springer.com/article/10.1186/s12968-018-0461-zAortaStiffnessPopulation-based study4D flow MRIPulse wave velocity |
| spellingShingle | Andreas Harloff Hanieh Mirzaee Thomas Lodemann Paul Hagenlocher Thomas Wehrum Judith Stuplich Anja Hennemuth Jürgen Hennig Sebastian Grundmann Werner Vach Determination of aortic stiffness using 4D flow cardiovascular magnetic resonance - a population-based study Journal of Cardiovascular Magnetic Resonance Aorta Stiffness Population-based study 4D flow MRI Pulse wave velocity |
| title | Determination of aortic stiffness using 4D flow cardiovascular magnetic resonance - a population-based study |
| title_full | Determination of aortic stiffness using 4D flow cardiovascular magnetic resonance - a population-based study |
| title_fullStr | Determination of aortic stiffness using 4D flow cardiovascular magnetic resonance - a population-based study |
| title_full_unstemmed | Determination of aortic stiffness using 4D flow cardiovascular magnetic resonance - a population-based study |
| title_short | Determination of aortic stiffness using 4D flow cardiovascular magnetic resonance - a population-based study |
| title_sort | determination of aortic stiffness using 4d flow cardiovascular magnetic resonance a population based study |
| topic | Aorta Stiffness Population-based study 4D flow MRI Pulse wave velocity |
| url | http://link.springer.com/article/10.1186/s12968-018-0461-z |
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