Reduction of disinfection efficacy of contact lens care products on the global market in the presence of contact lenses and cases
Objective Sight-threatening infections can be caused by pathogenic micro-organisms colonising the cornea, leading to microbial keratitis (MK). These micro-organisms can be introduced to the eye via improper contact lens use and care. MK can also result from ineffective contact lens care solutions (C...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-10-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/7/1/e000955.full |
| _version_ | 1827899402452205568 |
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| author | Paul Shannon Rhonda Walters Allison Campolo Elise Miller Manal M Gabriel Monica Crary Cindy McAnally |
| author_facet | Paul Shannon Rhonda Walters Allison Campolo Elise Miller Manal M Gabriel Monica Crary Cindy McAnally |
| author_sort | Paul Shannon |
| collection | DOAJ |
| description | Objective Sight-threatening infections can be caused by pathogenic micro-organisms colonising the cornea, leading to microbial keratitis (MK). These micro-organisms can be introduced to the eye via improper contact lens use and care. MK can also result from ineffective contact lens care solutions (CLCs), even if the patient is following best practice guidelines. Therefore, it is critical to understand the differences between the effectiveness of popular CLCs on the global market.Methods and analysis Following the International Standards Organisation standards 14 729 and 18259, bacteria (Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus), fungi (Candida albicans, Fusarium strains) and Acanthamoeba strains were inoculated into each CLC with and without contact lenses, and held for the manufacturer’s stated disinfection time. Plate counts were conducted to determine the number of surviving micro-organisms.Results All CLCs examined met the primary log reduction criteria during stand-alone testing for Pseudomonas, Staphylococcus, Candida and Fusarium. renu Multiplus, All Clean Soft, and Kombilösung Super did not meet the primary criteria when challenged with Serratia. Only OPTI-FREE Express exceeded 4 log reduction for both strains of Acanthamoeba tested. We noted a substantial reduction in disinfection efficacy when CLCs were challenged with Fusarium in the presence of lenses and cases versus stand-alone testing. OPTI-FREE Express demonstrated significantly less net log reduction loss than the other four CLCs tested.Conclusion Of the popular CLCs on the global market, the product which relies on dual biocides polyquaternium-1 and myristamidopropyl dimethylamine demonstrated the highest disinfection efficacy in microbial disinfection challenges in the absence and presence of contact lenses. |
| first_indexed | 2024-03-12T23:17:31Z |
| format | Article |
| id | doaj.art-918c2ca2f1714ff58e968da141f285c0 |
| institution | Directory Open Access Journal |
| issn | 2397-3269 |
| language | English |
| last_indexed | 2024-03-12T23:17:31Z |
| publishDate | 2022-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj.art-918c2ca2f1714ff58e968da141f285c02023-07-17T01:00:07ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692022-10-017110.1136/bmjophth-2021-000955Reduction of disinfection efficacy of contact lens care products on the global market in the presence of contact lenses and casesPaul Shannon0Rhonda Walters1Allison Campolo2Elise Miller3Manal M Gabriel4Monica Crary5Cindy McAnally6R&D Microbiology, Alcon Research, LLC, Fort Worth, Texas, USAR&D Microbiology, Alcon Research, LLC, Fort Worth, Texas, USAR&D Microbiology, Alcon Research, LLC, Fort Worth, Texas, USAR&D Microbiology, Alcon Research, LLC, Fort Worth, Texas, USAR&D Microbiology, Alcon Research, LLC, Fort Worth, Texas, USAR&D Microbiology, Alcon Research, LLC, Fort Worth, Texas, USAR&D Microbiology, Alcon Research, LLC, Fort Worth, Texas, USAObjective Sight-threatening infections can be caused by pathogenic micro-organisms colonising the cornea, leading to microbial keratitis (MK). These micro-organisms can be introduced to the eye via improper contact lens use and care. MK can also result from ineffective contact lens care solutions (CLCs), even if the patient is following best practice guidelines. Therefore, it is critical to understand the differences between the effectiveness of popular CLCs on the global market.Methods and analysis Following the International Standards Organisation standards 14 729 and 18259, bacteria (Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus), fungi (Candida albicans, Fusarium strains) and Acanthamoeba strains were inoculated into each CLC with and without contact lenses, and held for the manufacturer’s stated disinfection time. Plate counts were conducted to determine the number of surviving micro-organisms.Results All CLCs examined met the primary log reduction criteria during stand-alone testing for Pseudomonas, Staphylococcus, Candida and Fusarium. renu Multiplus, All Clean Soft, and Kombilösung Super did not meet the primary criteria when challenged with Serratia. Only OPTI-FREE Express exceeded 4 log reduction for both strains of Acanthamoeba tested. We noted a substantial reduction in disinfection efficacy when CLCs were challenged with Fusarium in the presence of lenses and cases versus stand-alone testing. OPTI-FREE Express demonstrated significantly less net log reduction loss than the other four CLCs tested.Conclusion Of the popular CLCs on the global market, the product which relies on dual biocides polyquaternium-1 and myristamidopropyl dimethylamine demonstrated the highest disinfection efficacy in microbial disinfection challenges in the absence and presence of contact lenses.https://bmjophth.bmj.com/content/7/1/e000955.full |
| spellingShingle | Paul Shannon Rhonda Walters Allison Campolo Elise Miller Manal M Gabriel Monica Crary Cindy McAnally Reduction of disinfection efficacy of contact lens care products on the global market in the presence of contact lenses and cases BMJ Open Ophthalmology |
| title | Reduction of disinfection efficacy of contact lens care products on the global market in the presence of contact lenses and cases |
| title_full | Reduction of disinfection efficacy of contact lens care products on the global market in the presence of contact lenses and cases |
| title_fullStr | Reduction of disinfection efficacy of contact lens care products on the global market in the presence of contact lenses and cases |
| title_full_unstemmed | Reduction of disinfection efficacy of contact lens care products on the global market in the presence of contact lenses and cases |
| title_short | Reduction of disinfection efficacy of contact lens care products on the global market in the presence of contact lenses and cases |
| title_sort | reduction of disinfection efficacy of contact lens care products on the global market in the presence of contact lenses and cases |
| url | https://bmjophth.bmj.com/content/7/1/e000955.full |
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