Novel Regulators of the IGF System in Cancer
The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metab...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/2/273 |
| _version_ | 1827589439145115648 |
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| author | Caterina Mancarella Andrea Morrione Katia Scotlandi |
| author_facet | Caterina Mancarella Andrea Morrione Katia Scotlandi |
| author_sort | Caterina Mancarella |
| collection | DOAJ |
| description | The insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metabolism and differentiation. Importantly, alterations in expression levels or activation of components of the IGF network are implicated in many pathological conditions including diabetes, obesity and cancer initiation and progression. In this review we will initially cover some general aspects of IGF action and regulation in cancer and then focus in particular on the role of transcriptional regulators and novel interacting proteins, which functionally contribute in fine tuning IGF1R signaling in several cancer models. A deeper understanding of the biological relevance of this network of IGF1R modulators might provide novel therapeutic opportunities to block this system in neoplasia. |
| first_indexed | 2024-03-09T00:56:43Z |
| format | Article |
| id | doaj.art-91925f0377c043e2ab84acb9d9c9f189 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T00:56:43Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-91925f0377c043e2ab84acb9d9c9f1892023-12-11T16:52:28ZengMDPI AGBiomolecules2218-273X2021-02-0111227310.3390/biom11020273Novel Regulators of the IGF System in CancerCaterina Mancarella0Andrea Morrione1Katia Scotlandi2IRCCS Istituto Ortopedico Rizzoli, Laboratory of Experimental Oncology, 40136 Bologna, ItalyDepartment of Biology, Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USAIRCCS Istituto Ortopedico Rizzoli, Laboratory of Experimental Oncology, 40136 Bologna, ItalyThe insulin-like growth factor (IGF) system is a dynamic network of proteins, which includes cognate ligands, membrane receptors, ligand binding proteins and functional downstream effectors. It plays a critical role in regulating several important physiological processes including cell growth, metabolism and differentiation. Importantly, alterations in expression levels or activation of components of the IGF network are implicated in many pathological conditions including diabetes, obesity and cancer initiation and progression. In this review we will initially cover some general aspects of IGF action and regulation in cancer and then focus in particular on the role of transcriptional regulators and novel interacting proteins, which functionally contribute in fine tuning IGF1R signaling in several cancer models. A deeper understanding of the biological relevance of this network of IGF1R modulators might provide novel therapeutic opportunities to block this system in neoplasia.https://www.mdpi.com/2218-273X/11/2/273IGF systemcancertranscriptional regulatorsfunctional regulationcircular RNAsIGF2BPs |
| spellingShingle | Caterina Mancarella Andrea Morrione Katia Scotlandi Novel Regulators of the IGF System in Cancer Biomolecules IGF system cancer transcriptional regulators functional regulation circular RNAs IGF2BPs |
| title | Novel Regulators of the IGF System in Cancer |
| title_full | Novel Regulators of the IGF System in Cancer |
| title_fullStr | Novel Regulators of the IGF System in Cancer |
| title_full_unstemmed | Novel Regulators of the IGF System in Cancer |
| title_short | Novel Regulators of the IGF System in Cancer |
| title_sort | novel regulators of the igf system in cancer |
| topic | IGF system cancer transcriptional regulators functional regulation circular RNAs IGF2BPs |
| url | https://www.mdpi.com/2218-273X/11/2/273 |
| work_keys_str_mv | AT caterinamancarella novelregulatorsoftheigfsystemincancer AT andreamorrione novelregulatorsoftheigfsystemincancer AT katiascotlandi novelregulatorsoftheigfsystemincancer |