Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of immunoglobulin A nephropathy
Background Imbalance of T helper (Th) 1/2 cells has been shown to contribute to the development of immunoglobulin A nephropathy (IgAN). To address the inconsistent results on the role of Th1/Th2 polarization, we evaluated the levels of Th1/Th2 cytokines in various samples from patients with IgAN. Me...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2021-03-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.krcp-ksn.org/upload/pdf/j-krcp-20-157.pdf |
| _version_ | 1819108099290562560 |
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| author | Sang Youb Han Kyung Hwan Jeong Chun-Gyoo Ihm Young Sun Kang Dae Ryong Cha |
| author_facet | Sang Youb Han Kyung Hwan Jeong Chun-Gyoo Ihm Young Sun Kang Dae Ryong Cha |
| author_sort | Sang Youb Han |
| collection | DOAJ |
| description | Background Imbalance of T helper (Th) 1/2 cells has been shown to contribute to the development of immunoglobulin A nephropathy (IgAN). To address the inconsistent results on the role of Th1/Th2 polarization, we evaluated the levels of Th1/Th2 cytokines in various samples from patients with IgAN. Methods Thirty-one patients with biopsy-proven IgAN (age, 34.48 ± 12.10 years) and 25 healthy controls (age, 44.84 ± 13.72 years) were enrolled. We evaluated the relationship between the levels of Th1/Th2 cytokines and the response to glucocorticoid treatment. Results The levels of serum interferon-gamma (IFNγ) and urinary monocyte chemoattractant peptide (MCP)-1 were higher in the IgAN group than in the control group. The levels of MCP-1 in urine and secreted by peripheral blood mononuclear cells (PBMCs) were significantly different among three groups categorized based on daily proteinuria. The level of urinary MCP-1 was significantly correlated with proteinuria. The levels of urinary MCP-1, serum interleukin (IL)-4, IFNγ, and IL-2 secreted by PBMCs and intrarenal IL-1 messenger RNA (mRNA) were significantly correlated with the ratio of proteinuria at 6 months to baseline proteinuria in patients undergoing glucocorticoid treatment. MCP-1 mRNA and protein levels were significantly upregulated in mesangial cells stimulated with IFNγ among representative Th1/Th2 cytokines. Conclusion IFNγ was shown to be a key cytokine in the pathogenic processes underlying IgAN, and its upregulation induced an increase in urinary MCP-1 production. These findings suggest that Th1 cytokines may play an important role in the development of IgAN. |
| first_indexed | 2024-12-22T03:04:33Z |
| format | Article |
| id | doaj.art-919269d6ffd8465aaa3322b069e21e56 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-12-22T03:04:33Z |
| publishDate | 2021-03-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-919269d6ffd8465aaa3322b069e21e562022-12-21T18:41:06ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402021-03-01401697610.23876/j.krcp.20.1576029Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of immunoglobulin A nephropathySang Youb Han0Kyung Hwan Jeong1Chun-Gyoo Ihm2Young Sun Kang3Dae Ryong Cha4 Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Republic of Korea Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Republic of KoreaBackground Imbalance of T helper (Th) 1/2 cells has been shown to contribute to the development of immunoglobulin A nephropathy (IgAN). To address the inconsistent results on the role of Th1/Th2 polarization, we evaluated the levels of Th1/Th2 cytokines in various samples from patients with IgAN. Methods Thirty-one patients with biopsy-proven IgAN (age, 34.48 ± 12.10 years) and 25 healthy controls (age, 44.84 ± 13.72 years) were enrolled. We evaluated the relationship between the levels of Th1/Th2 cytokines and the response to glucocorticoid treatment. Results The levels of serum interferon-gamma (IFNγ) and urinary monocyte chemoattractant peptide (MCP)-1 were higher in the IgAN group than in the control group. The levels of MCP-1 in urine and secreted by peripheral blood mononuclear cells (PBMCs) were significantly different among three groups categorized based on daily proteinuria. The level of urinary MCP-1 was significantly correlated with proteinuria. The levels of urinary MCP-1, serum interleukin (IL)-4, IFNγ, and IL-2 secreted by PBMCs and intrarenal IL-1 messenger RNA (mRNA) were significantly correlated with the ratio of proteinuria at 6 months to baseline proteinuria in patients undergoing glucocorticoid treatment. MCP-1 mRNA and protein levels were significantly upregulated in mesangial cells stimulated with IFNγ among representative Th1/Th2 cytokines. Conclusion IFNγ was shown to be a key cytokine in the pathogenic processes underlying IgAN, and its upregulation induced an increase in urinary MCP-1 production. These findings suggest that Th1 cytokines may play an important role in the development of IgAN.http://www.krcp-ksn.org/upload/pdf/j-krcp-20-157.pdfchemokine ccl2iga glomerulonephritisinterferonst helper 1 cellst helper 2 cells |
| spellingShingle | Sang Youb Han Kyung Hwan Jeong Chun-Gyoo Ihm Young Sun Kang Dae Ryong Cha Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of immunoglobulin A nephropathy Kidney Research and Clinical Practice chemokine ccl2 iga glomerulonephritis interferons t helper 1 cells t helper 2 cells |
| title | Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of immunoglobulin A nephropathy |
| title_full | Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of immunoglobulin A nephropathy |
| title_fullStr | Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of immunoglobulin A nephropathy |
| title_full_unstemmed | Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of immunoglobulin A nephropathy |
| title_short | Serum interferon-γ and urinary monocyte chemoattractant peptide-1 are important factors in the pathogenesis of immunoglobulin A nephropathy |
| title_sort | serum interferon γ and urinary monocyte chemoattractant peptide 1 are important factors in the pathogenesis of immunoglobulin a nephropathy |
| topic | chemokine ccl2 iga glomerulonephritis interferons t helper 1 cells t helper 2 cells |
| url | http://www.krcp-ksn.org/upload/pdf/j-krcp-20-157.pdf |
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