PINK1 and Parkin Ameliorate the Loss of Motor Activity and Mitochondrial Dysfunction Induced by Peripheral Neuropathy-Associated HSPB8 Mutants in <i>Drosophila</i> Models

PINK1 and Parkin Ameliorate the Loss of Motor Activity and Mitochondrial Dysfunction Induced by Peripheral Neuropathy-Associated HSPB8 Mutants in <i>Drosophila</i> Models

Charcot–Marie–Tooth disease (CMT) is a group of inherited peripheral nerve disorders characterized by progressive muscle weakness and atrophy, sensory loss, foot deformities and steppage gait. Missense mutations in the gene encoding the small heat shock protein HSPB8 (HSP22) have been associated wit...

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Bibliographic Details
Main Authors: Kyong-hwa Kang, Ji Eun Han, Hyunjin Kim, Sohee Kim, Young Bin Hong, Jeanho Yun, Soo Hyun Nam, Byung-Ok Choi, Hyongjong Koh
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomedicines
Subjects:
Charcot–Marie–Tooth disease
peripheral neuropathy
HSPB8
<i>Drosophila</i>
PINK1
parkin
Online Access:https://www.mdpi.com/2227-9059/11/3/832

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