Drug-Induced Lupus: A Forgotten Cause of Prolonged Pyrexia of Unknown Origin
The causes of a pyrexia of unknown origin (PUO) are broadly spread across infectious, malignant, or inflammatory conditions. The authors report a case of a 43-year-old female who initially presented with hypoxia and fevers secondary to a presumed acute viral or bacterial infectious pulmonary insult....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2022-07-01
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| Series: | Journal of Clinical Rheumatology and Immunology |
| Subjects: | |
| Online Access: | https://www.worldscientific.com/doi/10.1142/S2661341722720038 |
| _version_ | 1828805164988891136 |
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| author | Varsha Sivalingam Hillary Dinning Johnny Fang Yashneel Prasad Peter Jones Sanjaya Senanayake |
| author_facet | Varsha Sivalingam Hillary Dinning Johnny Fang Yashneel Prasad Peter Jones Sanjaya Senanayake |
| author_sort | Varsha Sivalingam |
| collection | DOAJ |
| description | The causes of a pyrexia of unknown origin (PUO) are broadly spread across infectious, malignant, or inflammatory conditions. The authors report a case of a 43-year-old female who initially presented with hypoxia and fevers secondary to a presumed acute viral or bacterial infectious pulmonary insult. However, fevers persisted despite pulmonary imaging remaining normal. The case subsequently evolved into a PUO with multiple lines of investigation proving inconclusive. No definitive diagnosis was made at the time of discharge; however, cessation of hydralazine was noted to coincide with the last of the patient’s fevers. Following the discharge, her anti-histone antibodies returned a positive result, and the diagnosis of drug-induced lupus was made with hydralazine as the presumed trigger. |
| first_indexed | 2024-12-12T07:50:41Z |
| format | Article |
| id | doaj.art-919533b6b533499e8559cd67aa915d23 |
| institution | Directory Open Access Journal |
| issn | 2661-3417 2661-3425 |
| language | English |
| last_indexed | 2024-12-12T07:50:41Z |
| publishDate | 2022-07-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Clinical Rheumatology and Immunology |
| spelling | doaj.art-919533b6b533499e8559cd67aa915d232022-12-22T00:32:27ZengWorld Scientific PublishingJournal of Clinical Rheumatology and Immunology2661-34172661-34252022-07-012201313610.1142/S2661341722720038Drug-Induced Lupus: A Forgotten Cause of Prolonged Pyrexia of Unknown OriginVarsha Sivalingam0Hillary Dinning1Johnny Fang2Yashneel Prasad3Peter Jones4Sanjaya Senanayake5Infectious Diseases Department, Canberra Hospital, ACT 2601, AustraliaInfectious Diseases Department, Canberra Hospital, ACT 2601, AustraliaInfectious Diseases Department, Canberra Hospital, ACT 2601, AustraliaRespiratory Department, Canberra Hospital, ACT 2601, AustraliaRespiratory Department, Canberra Hospital, ACT 2601, AustraliaInfectious Diseases Department, Canberra Hospital, ACT 2601, AustraliaThe causes of a pyrexia of unknown origin (PUO) are broadly spread across infectious, malignant, or inflammatory conditions. The authors report a case of a 43-year-old female who initially presented with hypoxia and fevers secondary to a presumed acute viral or bacterial infectious pulmonary insult. However, fevers persisted despite pulmonary imaging remaining normal. The case subsequently evolved into a PUO with multiple lines of investigation proving inconclusive. No definitive diagnosis was made at the time of discharge; however, cessation of hydralazine was noted to coincide with the last of the patient’s fevers. Following the discharge, her anti-histone antibodies returned a positive result, and the diagnosis of drug-induced lupus was made with hydralazine as the presumed trigger.https://www.worldscientific.com/doi/10.1142/S2661341722720038Case ReportPyrexia of Unknown OriginDrug-Induced LupusHydralazine |
| spellingShingle | Varsha Sivalingam Hillary Dinning Johnny Fang Yashneel Prasad Peter Jones Sanjaya Senanayake Drug-Induced Lupus: A Forgotten Cause of Prolonged Pyrexia of Unknown Origin Journal of Clinical Rheumatology and Immunology Case Report Pyrexia of Unknown Origin Drug-Induced Lupus Hydralazine |
| title | Drug-Induced Lupus: A Forgotten Cause of Prolonged Pyrexia of Unknown Origin |
| title_full | Drug-Induced Lupus: A Forgotten Cause of Prolonged Pyrexia of Unknown Origin |
| title_fullStr | Drug-Induced Lupus: A Forgotten Cause of Prolonged Pyrexia of Unknown Origin |
| title_full_unstemmed | Drug-Induced Lupus: A Forgotten Cause of Prolonged Pyrexia of Unknown Origin |
| title_short | Drug-Induced Lupus: A Forgotten Cause of Prolonged Pyrexia of Unknown Origin |
| title_sort | drug induced lupus a forgotten cause of prolonged pyrexia of unknown origin |
| topic | Case Report Pyrexia of Unknown Origin Drug-Induced Lupus Hydralazine |
| url | https://www.worldscientific.com/doi/10.1142/S2661341722720038 |
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