Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation
Background: Sub-optimal levels of vitamin D have been found to be highly prevalent in all age groups, with epidemiologic studies demonstrating a link between vitamin D deficiency and disease susceptibility, such as infection and cancer, and mortality rates. In adult transplant patients, it has been...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-04-01
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| Series: | Revista Brasileira de Hematologia e Hemoterapia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000200126&lng=en&tlng=en |
| _version_ | 1819168224871186432 |
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| author | Denise Johnsson Campos Gleyne Lopes Kujew Biagini Vaneuza Araujo Moreira Funke Carmem Maria Sales Bonfim César Luiz Boguszewski Victória Zeghbi Cochenski Borba |
| author_facet | Denise Johnsson Campos Gleyne Lopes Kujew Biagini Vaneuza Araujo Moreira Funke Carmem Maria Sales Bonfim César Luiz Boguszewski Victória Zeghbi Cochenski Borba |
| author_sort | Denise Johnsson Campos |
| collection | DOAJ |
| description | Background: Sub-optimal levels of vitamin D have been found to be highly prevalent in all age groups, with epidemiologic studies demonstrating a link between vitamin D deficiency and disease susceptibility, such as infection and cancer, and mortality rates. In adult transplant patients, it has been suggested that the immunomodulatory properties of vitamin D may have an important role in the prevention and treatment of graft-versus-host disease. Objective: The objective of this study was to assess serum 25-hydroxyvitamin D levels of children and adolescents submitted to allogeneic hematopoietic stem cell transplantation. Methods: Serum 25-hydroxyvitamin D levels of 66 patients, aged 4-20 years, were assessed at three stages: before hospitalization for hematopoietic stem cell transplantation and at 30 and 180 days after hematopoietic stem cell transplantation. The control group consisted of 25 healthy children. Results: At the pre-hematopoietic stem cell transplantation stage, patients had lower levels of 25-hydroxyvitamin D compared to controls (25.7 ± 12.3 ng/mL vs. 31.9 ± 9.9 ng/mL; p-value = 0.01), and a higher prevalence of 25-hydroxyvitamin D deficiency (32% vs. 8%; p-value = 0.01). Prevalence increased significantly after hematopoietic stem cell transplantation (p-value = 0.01) with half of the patients having vitamin D deficiency at 180 days after transplantation. At this stage, mean serum 25-hydroxyvitamin D levels were 20.9 ± 10.9 ng/mL, a significant decline in relation to baseline (p-value = 0.01). No correlation was found between 25-hydroxyvitamin D levels and vitamin D intake, graft-versus-host disease, corticoid use or survival rates. Conclusion: Low levels of 25-hydroxyvitamin D were detected even before hematopoietic stem cell transplantation and were significantly lower at 180 days after hematopoietic stem cell transplantation, thus recommending vitamin D supplementation for children and adolescents submitted to hematopoietic stem cell transplantation. |
| first_indexed | 2024-12-22T19:00:13Z |
| format | Article |
| id | doaj.art-91953aed5d974e4bb48042d022ee84f2 |
| institution | Directory Open Access Journal |
| issn | 1806-0870 |
| language | English |
| last_indexed | 2024-12-22T19:00:13Z |
| publishDate | 2014-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Revista Brasileira de Hematologia e Hemoterapia |
| spelling | doaj.art-91953aed5d974e4bb48042d022ee84f22022-12-21T18:15:58ZengElsevierRevista Brasileira de Hematologia e Hemoterapia1806-08702014-04-0136212613110.5581/1516-8484.20140029S1516-84842014000200126Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantationDenise Johnsson CamposGleyne Lopes Kujew BiaginiVaneuza Araujo Moreira FunkeCarmem Maria Sales BonfimCésar Luiz BoguszewskiVictória Zeghbi Cochenski BorbaBackground: Sub-optimal levels of vitamin D have been found to be highly prevalent in all age groups, with epidemiologic studies demonstrating a link between vitamin D deficiency and disease susceptibility, such as infection and cancer, and mortality rates. In adult transplant patients, it has been suggested that the immunomodulatory properties of vitamin D may have an important role in the prevention and treatment of graft-versus-host disease. Objective: The objective of this study was to assess serum 25-hydroxyvitamin D levels of children and adolescents submitted to allogeneic hematopoietic stem cell transplantation. Methods: Serum 25-hydroxyvitamin D levels of 66 patients, aged 4-20 years, were assessed at three stages: before hospitalization for hematopoietic stem cell transplantation and at 30 and 180 days after hematopoietic stem cell transplantation. The control group consisted of 25 healthy children. Results: At the pre-hematopoietic stem cell transplantation stage, patients had lower levels of 25-hydroxyvitamin D compared to controls (25.7 ± 12.3 ng/mL vs. 31.9 ± 9.9 ng/mL; p-value = 0.01), and a higher prevalence of 25-hydroxyvitamin D deficiency (32% vs. 8%; p-value = 0.01). Prevalence increased significantly after hematopoietic stem cell transplantation (p-value = 0.01) with half of the patients having vitamin D deficiency at 180 days after transplantation. At this stage, mean serum 25-hydroxyvitamin D levels were 20.9 ± 10.9 ng/mL, a significant decline in relation to baseline (p-value = 0.01). No correlation was found between 25-hydroxyvitamin D levels and vitamin D intake, graft-versus-host disease, corticoid use or survival rates. Conclusion: Low levels of 25-hydroxyvitamin D were detected even before hematopoietic stem cell transplantation and were significantly lower at 180 days after hematopoietic stem cell transplantation, thus recommending vitamin D supplementation for children and adolescents submitted to hematopoietic stem cell transplantation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000200126&lng=en&tlng=enHematopoietic stem cell transplantationVitamin DVitamin D deficiencyBone marrow transplantationChild nutrition |
| spellingShingle | Denise Johnsson Campos Gleyne Lopes Kujew Biagini Vaneuza Araujo Moreira Funke Carmem Maria Sales Bonfim César Luiz Boguszewski Victória Zeghbi Cochenski Borba Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation Revista Brasileira de Hematologia e Hemoterapia Hematopoietic stem cell transplantation Vitamin D Vitamin D deficiency Bone marrow transplantation Child nutrition |
| title | Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
| title_full | Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
| title_fullStr | Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
| title_full_unstemmed | Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
| title_short | Vitamin D deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
| title_sort | vitamin d deficiency in children and adolescents submitted to hematopoietic stem cell transplantation |
| topic | Hematopoietic stem cell transplantation Vitamin D Vitamin D deficiency Bone marrow transplantation Child nutrition |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000200126&lng=en&tlng=en |
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