Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy
We aimed to evaluate the effectiveness and safety of bismuth-containing quadruple therapy plus postural change after dosing for Helicobacter pylori eradication in gastrectomized patients. We compared 76 gastric stump patients with H. pylori infection (GS group) with 50 non-gastrectomized H. pylori-p...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2016-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000200702&lng=en&tlng=en |
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| author | F. Zhang Z.J. Bao D.M. Shi P. Xiang L. Xiao Y.Q. Huang G.S. Zhang S.M. Yin |
| author_facet | F. Zhang Z.J. Bao D.M. Shi P. Xiang L. Xiao Y.Q. Huang G.S. Zhang S.M. Yin |
| author_sort | F. Zhang |
| collection | DOAJ |
| description | We aimed to evaluate the effectiveness and safety of bismuth-containing quadruple therapy plus postural change after dosing for Helicobacter pylori eradication in gastrectomized patients. We compared 76 gastric stump patients with H. pylori infection (GS group) with 50 non-gastrectomized H. pylori-positive patients who met the treatment indication (controls). The GS group was divided into GS group 1 and GS group 2. All groups were administered bismuth potassium citrate (220 mg), esomeprazole (20 mg), amoxicillin (1.0 g), and furazolidone (100 mg) twice daily for 14 days. GS group 1 maintained a left lateral horizontal position for 30 min after dosing. H. pylori was detected using rapid urease testing and histologic examination of gastric mucosa before and 3 months after therapy. Mucosal histologic manifestations were evaluated using visual analog scales of the updated Sydney System. GS group 1 had a higher prevalence of eradication than the GS group 2 (intention-to-treat [ITT]: P=0.025; per-protocol [PP]: P=0.030), and the control group had a similar prevalence. GS group 2 had a lower prevalence of eradication than controls (ITT: P=0.006; PP: P=0.626). Scores for chronic inflammation and activity declined significantly (P<0.001) 3 months after treatment, whereas those for atrophy and intestinal metaplasia showed no significant change. Prevalence of adverse reactions was similar among groups during therapy (P=0.939). A bismuth-containing quadruple therapy regimen plus postural change after dosing appears to be a relatively safe, effective, economical, and practical method for H. pylori eradication in gastrectomized patients. |
| first_indexed | 2024-12-21T01:37:30Z |
| format | Article |
| id | doaj.art-9196dd4fd327426ebde182f9a8fbb457 |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-12-21T01:37:30Z |
| publishDate | 2016-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-9196dd4fd327426ebde182f9a8fbb4572022-12-21T19:20:14ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2016-01-0149210.1590/1414-431X20155080S0100-879X2016000200702Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomyF. ZhangZ.J. BaoD.M. ShiP. XiangL. XiaoY.Q. HuangG.S. ZhangS.M. YinWe aimed to evaluate the effectiveness and safety of bismuth-containing quadruple therapy plus postural change after dosing for Helicobacter pylori eradication in gastrectomized patients. We compared 76 gastric stump patients with H. pylori infection (GS group) with 50 non-gastrectomized H. pylori-positive patients who met the treatment indication (controls). The GS group was divided into GS group 1 and GS group 2. All groups were administered bismuth potassium citrate (220 mg), esomeprazole (20 mg), amoxicillin (1.0 g), and furazolidone (100 mg) twice daily for 14 days. GS group 1 maintained a left lateral horizontal position for 30 min after dosing. H. pylori was detected using rapid urease testing and histologic examination of gastric mucosa before and 3 months after therapy. Mucosal histologic manifestations were evaluated using visual analog scales of the updated Sydney System. GS group 1 had a higher prevalence of eradication than the GS group 2 (intention-to-treat [ITT]: P=0.025; per-protocol [PP]: P=0.030), and the control group had a similar prevalence. GS group 2 had a lower prevalence of eradication than controls (ITT: P=0.006; PP: P=0.626). Scores for chronic inflammation and activity declined significantly (P<0.001) 3 months after treatment, whereas those for atrophy and intestinal metaplasia showed no significant change. Prevalence of adverse reactions was similar among groups during therapy (P=0.939). A bismuth-containing quadruple therapy regimen plus postural change after dosing appears to be a relatively safe, effective, economical, and practical method for H. pylori eradication in gastrectomized patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000200702&lng=en&tlng=enHelicobacter pyloriGastrectomyGastric stumpEradicationEfficacy |
| spellingShingle | F. Zhang Z.J. Bao D.M. Shi P. Xiang L. Xiao Y.Q. Huang G.S. Zhang S.M. Yin Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy Brazilian Journal of Medical and Biological Research Helicobacter pylori Gastrectomy Gastric stump Eradication Efficacy |
| title | Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy |
| title_full | Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy |
| title_fullStr | Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy |
| title_full_unstemmed | Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy |
| title_short | Efficacy of a quadruple therapy regimen for Helicobacter pylori eradication after partial gastrectomy |
| title_sort | efficacy of a quadruple therapy regimen for helicobacter pylori eradication after partial gastrectomy |
| topic | Helicobacter pylori Gastrectomy Gastric stump Eradication Efficacy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000200702&lng=en&tlng=en |
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