The effect of omega-3 fatty acid supplementation on oxidative stress in continuous ambulatory peritoneal dialysis patients
Background: End stage renal disease (ESRD) is a condition that inflammation and oxidative stress plays an important role in damaging to tissues, especially, in the vascular system. The effect of omega-3 fatty acids is well-documented in some inflammatory diseases via eicosapentanoic acid and docosah...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | Advanced Biomedical Research |
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| Online Access: | http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=143;epage=143;aulast=Taheri |
| _version_ | 1830285798959742976 |
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| author | Shahram Taheri Nooshin Keyvandarian Firouzeh Moeinzadeh Mojgan Mortazavi Afsoon Emami Naini |
| author_facet | Shahram Taheri Nooshin Keyvandarian Firouzeh Moeinzadeh Mojgan Mortazavi Afsoon Emami Naini |
| author_sort | Shahram Taheri |
| collection | DOAJ |
| description | Background: End stage renal disease (ESRD) is a condition that inflammation and oxidative stress plays an important role in damaging to tissues, especially, in the vascular system. The effect of omega-3 fatty acids is well-documented in some inflammatory diseases via eicosapentanoic acid and docosahexanoic acid components of fish oil. The aim of this study was to investigate the effects of dietary omega-3 fatty acid supplementation on levels of lipid peroxidation and oxidative sttress in ESRD patients.
Materials and Methods: This randomized controlled double-blind clinical trial consisted of 90 patients on chronic ambulatory peritoneal dialysis (CAPD). One group was treated orally with 3000 mg omega-3, per day for 8 weeks (n = 45) and the other matched group by placebo (n = 45). Serum levels of lipids, iron, ferritin, Protrombin Time, Partial thromboplastin time, superoxide dismutase (SOD), and reduced glutathione (GH) were measured at the beginning and at 8 weeks.
Results: Our results showed that SOD and reduced GH were not significantly changed in omega-3 group where lipid profile showed no significant changes too. Erythropoietin requirements also had no significant differences.
Conclusion: Incorporation of omega-3 fatty acids to CAPD patients had no beneficial effects on oxidative stress but should evaluate more. |
| first_indexed | 2024-12-19T03:46:06Z |
| format | Article |
| id | doaj.art-919a6cb120504c159fa3b1273b8d253d |
| institution | Directory Open Access Journal |
| issn | 2277-9175 2277-9175 |
| language | English |
| last_indexed | 2024-12-19T03:46:06Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Advanced Biomedical Research |
| spelling | doaj.art-919a6cb120504c159fa3b1273b8d253d2022-12-21T20:37:06ZengWolters Kluwer Medknow PublicationsAdvanced Biomedical Research2277-91752277-91752014-01-013114314310.4103/2277-9175.135160The effect of omega-3 fatty acid supplementation on oxidative stress in continuous ambulatory peritoneal dialysis patientsShahram TaheriNooshin KeyvandarianFirouzeh MoeinzadehMojgan MortazaviAfsoon Emami NainiBackground: End stage renal disease (ESRD) is a condition that inflammation and oxidative stress plays an important role in damaging to tissues, especially, in the vascular system. The effect of omega-3 fatty acids is well-documented in some inflammatory diseases via eicosapentanoic acid and docosahexanoic acid components of fish oil. The aim of this study was to investigate the effects of dietary omega-3 fatty acid supplementation on levels of lipid peroxidation and oxidative sttress in ESRD patients. Materials and Methods: This randomized controlled double-blind clinical trial consisted of 90 patients on chronic ambulatory peritoneal dialysis (CAPD). One group was treated orally with 3000 mg omega-3, per day for 8 weeks (n = 45) and the other matched group by placebo (n = 45). Serum levels of lipids, iron, ferritin, Protrombin Time, Partial thromboplastin time, superoxide dismutase (SOD), and reduced glutathione (GH) were measured at the beginning and at 8 weeks. Results: Our results showed that SOD and reduced GH were not significantly changed in omega-3 group where lipid profile showed no significant changes too. Erythropoietin requirements also had no significant differences. Conclusion: Incorporation of omega-3 fatty acids to CAPD patients had no beneficial effects on oxidative stress but should evaluate more.http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=143;epage=143;aulast=TaheriChronic ambulatory peritoneal dialysisomega-3 fatty acidsoxidative stressreduced glutathionesuperoxide dismutase |
| spellingShingle | Shahram Taheri Nooshin Keyvandarian Firouzeh Moeinzadeh Mojgan Mortazavi Afsoon Emami Naini The effect of omega-3 fatty acid supplementation on oxidative stress in continuous ambulatory peritoneal dialysis patients Advanced Biomedical Research Chronic ambulatory peritoneal dialysis omega-3 fatty acids oxidative stress reduced glutathione superoxide dismutase |
| title | The effect of omega-3 fatty acid supplementation on oxidative stress in continuous ambulatory peritoneal dialysis patients |
| title_full | The effect of omega-3 fatty acid supplementation on oxidative stress in continuous ambulatory peritoneal dialysis patients |
| title_fullStr | The effect of omega-3 fatty acid supplementation on oxidative stress in continuous ambulatory peritoneal dialysis patients |
| title_full_unstemmed | The effect of omega-3 fatty acid supplementation on oxidative stress in continuous ambulatory peritoneal dialysis patients |
| title_short | The effect of omega-3 fatty acid supplementation on oxidative stress in continuous ambulatory peritoneal dialysis patients |
| title_sort | effect of omega 3 fatty acid supplementation on oxidative stress in continuous ambulatory peritoneal dialysis patients |
| topic | Chronic ambulatory peritoneal dialysis omega-3 fatty acids oxidative stress reduced glutathione superoxide dismutase |
| url | http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=143;epage=143;aulast=Taheri |
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