DNA Oligonucleotides as Antivirals and Vaccine Constituents against SARS Coronaviruses: A Prospective Tool for Immune System Tuning
The SARS-CoV-2 pandemic has demonstrated the need to create highly effective antivirals and vaccines against various RNA viruses, including SARS coronaviruses. This paper provides a short review of innovative strategies in the development of antivirals and vaccines against SARS coronaviruses, with a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/2/1553 |
| _version_ | 1797441228739969024 |
|---|---|
| author | Volodymyr V. Oberemok Oksana A. Andreeva Edie E. Alieva |
| author_facet | Volodymyr V. Oberemok Oksana A. Andreeva Edie E. Alieva |
| author_sort | Volodymyr V. Oberemok |
| collection | DOAJ |
| description | The SARS-CoV-2 pandemic has demonstrated the need to create highly effective antivirals and vaccines against various RNA viruses, including SARS coronaviruses. This paper provides a short review of innovative strategies in the development of antivirals and vaccines against SARS coronaviruses, with a focus on antisense antivirals, oligonucleotide adjuvants in vaccines, and oligonucleotide vaccines. Well-developed viral genomic databases create new opportunities for the development of innovative vaccines and antivirals using a post-genomic platform. The most effective vaccines against SARS coronaviruses are those able to form highly effective memory cells for both humoral and cellular immunity. The most effective antivirals need to efficiently stop viral replication without side effects. Oligonucleotide antivirals and vaccines can resist the rapidly changing genomic sequences of SARS coronaviruses using conserved regions of their genomes to generate a long-term immune response. Oligonucleotides have been used as excellent adjuvants for decades, and increasing data show that oligonucleotides could serve as antisense antivirals and antigens in vaccine formulations, becoming a prospective tool for immune system tuning. |
| first_indexed | 2024-03-09T12:20:00Z |
| format | Article |
| id | doaj.art-919b01cdcc9a4af59fde79d9afff0fba |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:20:00Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-919b01cdcc9a4af59fde79d9afff0fba2023-11-30T22:42:12ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01242155310.3390/ijms24021553DNA Oligonucleotides as Antivirals and Vaccine Constituents against SARS Coronaviruses: A Prospective Tool for Immune System TuningVolodymyr V. Oberemok0Oksana A. Andreeva1Edie E. Alieva2Department of Molecular Genetics and Biotechnologies, Institute of Biochemical Technologies, Ecology and Pharmacy, V.I. Vernadsky Crimean Federal University, 295007 Simferopol, CrimeaDepartment of Molecular Genetics and Biotechnologies, Institute of Biochemical Technologies, Ecology and Pharmacy, V.I. Vernadsky Crimean Federal University, 295007 Simferopol, CrimeaDepartment of Molecular Genetics and Biotechnologies, Institute of Biochemical Technologies, Ecology and Pharmacy, V.I. Vernadsky Crimean Federal University, 295007 Simferopol, CrimeaThe SARS-CoV-2 pandemic has demonstrated the need to create highly effective antivirals and vaccines against various RNA viruses, including SARS coronaviruses. This paper provides a short review of innovative strategies in the development of antivirals and vaccines against SARS coronaviruses, with a focus on antisense antivirals, oligonucleotide adjuvants in vaccines, and oligonucleotide vaccines. Well-developed viral genomic databases create new opportunities for the development of innovative vaccines and antivirals using a post-genomic platform. The most effective vaccines against SARS coronaviruses are those able to form highly effective memory cells for both humoral and cellular immunity. The most effective antivirals need to efficiently stop viral replication without side effects. Oligonucleotide antivirals and vaccines can resist the rapidly changing genomic sequences of SARS coronaviruses using conserved regions of their genomes to generate a long-term immune response. Oligonucleotides have been used as excellent adjuvants for decades, and increasing data show that oligonucleotides could serve as antisense antivirals and antigens in vaccine formulations, becoming a prospective tool for immune system tuning.https://www.mdpi.com/1422-0067/24/2/1553antisense oligonucleotidesantisense antiviralsoligonucleotide adjuvantsoligonucleotide vaccinesSARS coronavirusesinnate immunity |
| spellingShingle | Volodymyr V. Oberemok Oksana A. Andreeva Edie E. Alieva DNA Oligonucleotides as Antivirals and Vaccine Constituents against SARS Coronaviruses: A Prospective Tool for Immune System Tuning International Journal of Molecular Sciences antisense oligonucleotides antisense antivirals oligonucleotide adjuvants oligonucleotide vaccines SARS coronaviruses innate immunity |
| title | DNA Oligonucleotides as Antivirals and Vaccine Constituents against SARS Coronaviruses: A Prospective Tool for Immune System Tuning |
| title_full | DNA Oligonucleotides as Antivirals and Vaccine Constituents against SARS Coronaviruses: A Prospective Tool for Immune System Tuning |
| title_fullStr | DNA Oligonucleotides as Antivirals and Vaccine Constituents against SARS Coronaviruses: A Prospective Tool for Immune System Tuning |
| title_full_unstemmed | DNA Oligonucleotides as Antivirals and Vaccine Constituents against SARS Coronaviruses: A Prospective Tool for Immune System Tuning |
| title_short | DNA Oligonucleotides as Antivirals and Vaccine Constituents against SARS Coronaviruses: A Prospective Tool for Immune System Tuning |
| title_sort | dna oligonucleotides as antivirals and vaccine constituents against sars coronaviruses a prospective tool for immune system tuning |
| topic | antisense oligonucleotides antisense antivirals oligonucleotide adjuvants oligonucleotide vaccines SARS coronaviruses innate immunity |
| url | https://www.mdpi.com/1422-0067/24/2/1553 |
| work_keys_str_mv | AT volodymyrvoberemok dnaoligonucleotidesasantiviralsandvaccineconstituentsagainstsarscoronavirusesaprospectivetoolforimmunesystemtuning AT oksanaaandreeva dnaoligonucleotidesasantiviralsandvaccineconstituentsagainstsarscoronavirusesaprospectivetoolforimmunesystemtuning AT edieealieva dnaoligonucleotidesasantiviralsandvaccineconstituentsagainstsarscoronavirusesaprospectivetoolforimmunesystemtuning |