RNA cytosine methyltransferase NSUN5 promotes protein synthesis and tumorigenic phenotypes in glioblastoma

RNA cytosine methyltransferase NSUN5 promotes protein synthesis and tumorigenic phenotypes in glioblastoma

Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor in adults. The standard treatment achieves a median overall survival for GBM patients of only 15 months. Hence, novel therapies based on an increased understanding of the mechanistic underpinnings of GBM are desperate...

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Bibliographic Details
Main Authors: Jiesi Zhou, Yan Shu Kong, Krista M. Vincent, Dylan Dieters‐Castator, Amirali B. Bukhari, Darryl Glubrecht, Rong‐Zong Liu, Douglas Quilty, Scott D. Findlay, Xiaowei Huang, Zhihua Xu, Rui Zhe Yang, Lanyue Zhang, Emily Tang, Gilles Lajoie, David D. Eisenstat, Armin M. Gamper, Richard Fahlman, Roseline Godbout, Lynne‐Marie Postovit, YangXin Fu
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Molecular Oncology
Subjects:
glioblastoma
NSUN5
protein synthesis
RNA cytosine methylation
Online Access:https://doi.org/10.1002/1878-0261.13434

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