Associations of body shape phenotypes with sex steroids and their binding proteins in the UK Biobank cohort
Abstract Associations of sex steroids and their binding proteins with body shape are unclear, because waist and hip circumference are correlated strongly with body size. We defined body shape using “a body shape index” (ABSI) and hip index (HI), which are independent of weight and height by design,...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-14439-9 |
| _version_ | 1811334271143510016 |
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| author | Sofia Christakoudi Elio Riboli Evangelos Evangelou Konstantinos K. Tsilidis |
| author_facet | Sofia Christakoudi Elio Riboli Evangelos Evangelou Konstantinos K. Tsilidis |
| author_sort | Sofia Christakoudi |
| collection | DOAJ |
| description | Abstract Associations of sex steroids and their binding proteins with body shape are unclear, because waist and hip circumference are correlated strongly with body size. We defined body shape using “a body shape index” (ABSI) and hip index (HI), which are independent of weight and height by design, and examined associations in multivariable generalised linear models for the UK Biobank cohort (179,902 men, 207,444 women). Total testosterone was associated inversely with ABSI, especially in men. Free testosterone was lowest for large-ABSI-large-HI (“wide”) and highest for small-ABSI-small-HI (“slim”) in men, but lowest for small-ABSI-large-HI (“pear”) and highest for large-ABSI-small-HI (“apple”) in women. Oestradiol was associated inversely with ABSI in obese pre-menopausal women but positively with HI in obese men and post-menopausal women not using hormone replacement therapy. Sex-hormone binding globulin (SHBG) was associated inversely with ABSI but positively with HI and was lowest for “apple” and highest for “pear” phenotype in both sexes. Albumin was associated inversely with HI in women, but matched the pattern of free testosterone in obese men (lowest for “wide”, highest for “slim” phenotype). In conclusion, sex steroids and their binding proteins are associated with body shape, including hip as well as waist size, independent of body size. |
| first_indexed | 2024-04-13T17:06:12Z |
| format | Article |
| id | doaj.art-919b4d683f0b4cb1b79e1ad4ded062e2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T17:06:12Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-919b4d683f0b4cb1b79e1ad4ded062e22022-12-22T02:38:28ZengNature PortfolioScientific Reports2045-23222022-06-0112111410.1038/s41598-022-14439-9Associations of body shape phenotypes with sex steroids and their binding proteins in the UK Biobank cohortSofia Christakoudi0Elio Riboli1Evangelos Evangelou2Konstantinos K. Tsilidis3Department of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonAbstract Associations of sex steroids and their binding proteins with body shape are unclear, because waist and hip circumference are correlated strongly with body size. We defined body shape using “a body shape index” (ABSI) and hip index (HI), which are independent of weight and height by design, and examined associations in multivariable generalised linear models for the UK Biobank cohort (179,902 men, 207,444 women). Total testosterone was associated inversely with ABSI, especially in men. Free testosterone was lowest for large-ABSI-large-HI (“wide”) and highest for small-ABSI-small-HI (“slim”) in men, but lowest for small-ABSI-large-HI (“pear”) and highest for large-ABSI-small-HI (“apple”) in women. Oestradiol was associated inversely with ABSI in obese pre-menopausal women but positively with HI in obese men and post-menopausal women not using hormone replacement therapy. Sex-hormone binding globulin (SHBG) was associated inversely with ABSI but positively with HI and was lowest for “apple” and highest for “pear” phenotype in both sexes. Albumin was associated inversely with HI in women, but matched the pattern of free testosterone in obese men (lowest for “wide”, highest for “slim” phenotype). In conclusion, sex steroids and their binding proteins are associated with body shape, including hip as well as waist size, independent of body size.https://doi.org/10.1038/s41598-022-14439-9 |
| spellingShingle | Sofia Christakoudi Elio Riboli Evangelos Evangelou Konstantinos K. Tsilidis Associations of body shape phenotypes with sex steroids and their binding proteins in the UK Biobank cohort Scientific Reports |
| title | Associations of body shape phenotypes with sex steroids and their binding proteins in the UK Biobank cohort |
| title_full | Associations of body shape phenotypes with sex steroids and their binding proteins in the UK Biobank cohort |
| title_fullStr | Associations of body shape phenotypes with sex steroids and their binding proteins in the UK Biobank cohort |
| title_full_unstemmed | Associations of body shape phenotypes with sex steroids and their binding proteins in the UK Biobank cohort |
| title_short | Associations of body shape phenotypes with sex steroids and their binding proteins in the UK Biobank cohort |
| title_sort | associations of body shape phenotypes with sex steroids and their binding proteins in the uk biobank cohort |
| url | https://doi.org/10.1038/s41598-022-14439-9 |
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