Transcriptomic Alterations in Lung Adenocarcinoma Unveil New Mechanisms Targeted by the TBX2 Subfamily of Tumor Suppressor Genes

Transcriptomic Alterations in Lung Adenocarcinoma Unveil New Mechanisms Targeted by the TBX2 Subfamily of Tumor Suppressor Genes

T-box (TBX) transcription factors are evolutionary conserved genes and master transcriptional regulators. In mammals, TBX2 subfamily (TBX2, TBX3, TBX4, and TBX5) genes are expressed in the developing lung bud and tracheae. Our group previously showed that the expression of TBX2 subfamily was signifi...

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Bibliographic Details
Main Authors: Athar Khalil, Batoul Dekmak, Fouad Boulos, Jake Kantrowitz, Avrum Spira, Junya Fujimoto, Humam Kadara, Nehme El-Hachem, Georges Nemer
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Oncology
Subjects:
transcriptomics
T-Box
tumor suppressor gene
demethylation
lung adenocarcinoma
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00482/full

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