Decrease in Diversity of Propionibacterium acnes Phylotypes in Patients with Severe Acne on the Back
Propionibacterium acnes, a major member of normal skin microbiota, is subdivided into 6 phylotypes: IA1, IA2, IB, IC, II and III. This study investigated P. acnes subgroups on the face and back in patients with severe acne and in healthy controls. In 71.4% of patients with severe acne, P. acnes phyl...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2017-11-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2847
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| _version_ | 1819003828268171264 |
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| author | Marie-Ange Dagnelie Stéphane Corvec Mélanie Saint-Jean Valérie Bourdès Jean-Michel Nguyen Amir Khammari Brigitte Dréno |
| author_facet | Marie-Ange Dagnelie Stéphane Corvec Mélanie Saint-Jean Valérie Bourdès Jean-Michel Nguyen Amir Khammari Brigitte Dréno |
| author_sort | Marie-Ange Dagnelie |
| collection | DOAJ |
| description | Propionibacterium acnes, a major member of normal skin microbiota, is subdivided into 6 phylotypes: IA1, IA2, IB, IC, II and III. This study investigated P. acnes subgroups on the face and back in patients with severe acne and in healthy controls. In 71.4% of patients with severe acne, P. acnes phylotypes were identical on the face and back, whereas this was the case in only 45.5% of healthy controls. The healthy group carried phylotypes IA1 (39.1%) and II (43.4%), whereas the acne group carried a high predominance of IA1 (84.4%), especially on the back (95.6%). In addition, the single-locus sequence typing (SLST) method revealed A1 to be the predominant type on the back of patients with acne, compared with a wide diversity in the healthy group. We report here that severity of acne on the back is associated with loss of diversity of P. acnes phylotype, with a major predominance of phylotype IA1. The change in balance of cutaneous P. acnes subgroups might be an inducing factor in the activation of P. acnes, which could trigger inflammation. |
| first_indexed | 2024-12-20T23:27:12Z |
| format | Article |
| id | doaj.art-919d83bcbc0240a0b687c53af219321a |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-12-20T23:27:12Z |
| publishDate | 2017-11-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-919d83bcbc0240a0b687c53af219321a2022-12-21T19:23:22ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572017-11-0198226226710.2340/00015555-28475120Decrease in Diversity of Propionibacterium acnes Phylotypes in Patients with Severe Acne on the BackMarie-Ange Dagnelie0Stéphane CorvecMélanie Saint-JeanValérie BourdèsJean-Michel NguyenAmir KhammariBrigitte Dréno CIC, INSERM U1232, FR-44093 Nantes, France. Propionibacterium acnes, a major member of normal skin microbiota, is subdivided into 6 phylotypes: IA1, IA2, IB, IC, II and III. This study investigated P. acnes subgroups on the face and back in patients with severe acne and in healthy controls. In 71.4% of patients with severe acne, P. acnes phylotypes were identical on the face and back, whereas this was the case in only 45.5% of healthy controls. The healthy group carried phylotypes IA1 (39.1%) and II (43.4%), whereas the acne group carried a high predominance of IA1 (84.4%), especially on the back (95.6%). In addition, the single-locus sequence typing (SLST) method revealed A1 to be the predominant type on the back of patients with acne, compared with a wide diversity in the healthy group. We report here that severity of acne on the back is associated with loss of diversity of P. acnes phylotype, with a major predominance of phylotype IA1. The change in balance of cutaneous P. acnes subgroups might be an inducing factor in the activation of P. acnes, which could trigger inflammation. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2847 acne,P.acnesphylotypesclonalcomplexesSLST-types |
| spellingShingle | Marie-Ange Dagnelie Stéphane Corvec Mélanie Saint-Jean Valérie Bourdès Jean-Michel Nguyen Amir Khammari Brigitte Dréno Decrease in Diversity of Propionibacterium acnes Phylotypes in Patients with Severe Acne on the Back Acta Dermato-Venereologica acne,P.acnesphylotypes clonalcomplexes SLST-types |
| title | Decrease in Diversity of Propionibacterium acnes Phylotypes in Patients with Severe Acne on the Back |
| title_full | Decrease in Diversity of Propionibacterium acnes Phylotypes in Patients with Severe Acne on the Back |
| title_fullStr | Decrease in Diversity of Propionibacterium acnes Phylotypes in Patients with Severe Acne on the Back |
| title_full_unstemmed | Decrease in Diversity of Propionibacterium acnes Phylotypes in Patients with Severe Acne on the Back |
| title_short | Decrease in Diversity of Propionibacterium acnes Phylotypes in Patients with Severe Acne on the Back |
| title_sort | decrease in diversity of propionibacterium acnes phylotypes in patients with severe acne on the back |
| topic | acne,P.acnesphylotypes clonalcomplexes SLST-types |
| url |
https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2847
|
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