Multifunctional Oxidized Dextran as a Matrix for Stabilization of Octahedral Molybdenum and Tungsten Iodide Clusters in Aqueous Media
Due to their high abundance, polymeric character, and chemical tunability, polysaccharides are perfect candidates for the stabilization of photoactive nanoscale objects, which are of great interest in modern science but can be unstable in aqueous media. In this work, we have demonstrated the relevan...
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/12/10010 |
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| author | Ekaterina V. Pronina Yuri A. Vorotnikov Tatiana N. Pozmogova Alphiya R. Tsygankova Kaplan Kirakci Kamil Lang Michael A. Shestopalov |
| author_facet | Ekaterina V. Pronina Yuri A. Vorotnikov Tatiana N. Pozmogova Alphiya R. Tsygankova Kaplan Kirakci Kamil Lang Michael A. Shestopalov |
| author_sort | Ekaterina V. Pronina |
| collection | DOAJ |
| description | Due to their high abundance, polymeric character, and chemical tunability, polysaccharides are perfect candidates for the stabilization of photoactive nanoscale objects, which are of great interest in modern science but can be unstable in aqueous media. In this work, we have demonstrated the relevance of oxidized dextran polysaccharide, obtained via a simple reaction with H<sub>2</sub>O<sub>2</sub>, towards the stabilization of photoactive octahedral molybdenum and tungsten iodide cluster complexes [M<sub>6</sub>I<sub>8</sub>}(DMSO)<sub>6</sub>](NO<sub>3</sub>)<sub>4</sub> in aqueous and culture media. The cluster-containing materials were obtained by co-precipitation of the starting reagents in DMSO solution. According to the data obtained, the amount and ratio of functional carbonyl and carboxylic groups as well as the molecular weight of oxidized dextran strongly affect the extent of stabilization, i.e., high loading of aldehyde groups and high molecular weight increase the stability, while acidic groups have some negative impact on the stability. The most stable material based on the tungsten cluster complex exhibited low dark and moderate photoinduced cytotoxicity, which together with high cellular uptake makes these polymers promising for the fields of bioimaging and PDT. |
| first_indexed | 2024-03-11T02:21:37Z |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T02:21:37Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-919e60f9384a45e1b0f03f604cad1fe42023-11-18T10:47:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124121001010.3390/ijms241210010Multifunctional Oxidized Dextran as a Matrix for Stabilization of Octahedral Molybdenum and Tungsten Iodide Clusters in Aqueous MediaEkaterina V. Pronina0Yuri A. Vorotnikov1Tatiana N. Pozmogova2Alphiya R. Tsygankova3Kaplan Kirakci4Kamil Lang5Michael A. Shestopalov6Nikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., Novosibirsk 630090, RussiaNikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., Novosibirsk 630090, RussiaNikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., Novosibirsk 630090, RussiaNikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., Novosibirsk 630090, RussiaInstitute of Inorganic Chemistry of the Czech Academy of Sciences, Řež 1001, 250 68 Husinec-Řež, Czech RepublicInstitute of Inorganic Chemistry of the Czech Academy of Sciences, Řež 1001, 250 68 Husinec-Řež, Czech RepublicNikolaev Institute of Inorganic Chemistry SB RAS, 3 Acad. Lavrentiev Ave., Novosibirsk 630090, RussiaDue to their high abundance, polymeric character, and chemical tunability, polysaccharides are perfect candidates for the stabilization of photoactive nanoscale objects, which are of great interest in modern science but can be unstable in aqueous media. In this work, we have demonstrated the relevance of oxidized dextran polysaccharide, obtained via a simple reaction with H<sub>2</sub>O<sub>2</sub>, towards the stabilization of photoactive octahedral molybdenum and tungsten iodide cluster complexes [M<sub>6</sub>I<sub>8</sub>}(DMSO)<sub>6</sub>](NO<sub>3</sub>)<sub>4</sub> in aqueous and culture media. The cluster-containing materials were obtained by co-precipitation of the starting reagents in DMSO solution. According to the data obtained, the amount and ratio of functional carbonyl and carboxylic groups as well as the molecular weight of oxidized dextran strongly affect the extent of stabilization, i.e., high loading of aldehyde groups and high molecular weight increase the stability, while acidic groups have some negative impact on the stability. The most stable material based on the tungsten cluster complex exhibited low dark and moderate photoinduced cytotoxicity, which together with high cellular uptake makes these polymers promising for the fields of bioimaging and PDT.https://www.mdpi.com/1422-0067/24/12/10010octahedral iodide clustermolybdenumtungstenoxidized dextran polysaccharidehydrolysisstability |
| spellingShingle | Ekaterina V. Pronina Yuri A. Vorotnikov Tatiana N. Pozmogova Alphiya R. Tsygankova Kaplan Kirakci Kamil Lang Michael A. Shestopalov Multifunctional Oxidized Dextran as a Matrix for Stabilization of Octahedral Molybdenum and Tungsten Iodide Clusters in Aqueous Media International Journal of Molecular Sciences octahedral iodide cluster molybdenum tungsten oxidized dextran polysaccharide hydrolysis stability |
| title | Multifunctional Oxidized Dextran as a Matrix for Stabilization of Octahedral Molybdenum and Tungsten Iodide Clusters in Aqueous Media |
| title_full | Multifunctional Oxidized Dextran as a Matrix for Stabilization of Octahedral Molybdenum and Tungsten Iodide Clusters in Aqueous Media |
| title_fullStr | Multifunctional Oxidized Dextran as a Matrix for Stabilization of Octahedral Molybdenum and Tungsten Iodide Clusters in Aqueous Media |
| title_full_unstemmed | Multifunctional Oxidized Dextran as a Matrix for Stabilization of Octahedral Molybdenum and Tungsten Iodide Clusters in Aqueous Media |
| title_short | Multifunctional Oxidized Dextran as a Matrix for Stabilization of Octahedral Molybdenum and Tungsten Iodide Clusters in Aqueous Media |
| title_sort | multifunctional oxidized dextran as a matrix for stabilization of octahedral molybdenum and tungsten iodide clusters in aqueous media |
| topic | octahedral iodide cluster molybdenum tungsten oxidized dextran polysaccharide hydrolysis stability |
| url | https://www.mdpi.com/1422-0067/24/12/10010 |
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