In Vivo Evaluation of AT-101 (R-(—)-Gossypol Acetic Acid) in Androgen-Independent Growth of VCaP Prostate Cancer Cells in Combination with Surgical Castration

In Vivo Evaluation of AT-101 (R-(—)-Gossypol Acetic Acid) in Androgen-Independent Growth of VCaP Prostate Cancer Cells in Combination with Surgical Castration

PURPOSE: Upregulation of Bcl-2 family members is a well-established mechanism in the development of androgen-independent prostate cancer. Inhibition of the antiapoptotic proteins Bcl-2 and Mcl-1 may delay the transition to androgen-independent growth. EXPERIMENTAL DESIGN: We have established a prost...

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Bibliographic Details
Main Authors: Robert D. Loberg, Natalie McGregor, Chi Ying, Erin Sargent, Kenneth J. Pienta
Format: Article
Language:English
Published: Elsevier 2007-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Apoptosis
Bcl-2
BH3 domain
hormone refractory
orchiectomy
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607801138

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