Discoordination of the processes of activation and suppression of immunocompetent cells during mesotherapy with hyaluronic acid
Objective. The study aimed to assess the dynamics of the systemic immune response in patients during mesotherapy with hyaluronic acid (HA).Materials and methods. The observation group included 26 women who received the first-time mesocorrection with drugs based on hyaluronic acid (HA). Injections of...
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| Format: | Article |
| Language: | English |
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2021-03-01
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| Series: | Медицинский вестник Юга России |
| Subjects: | |
| Online Access: | https://www.medicalherald.ru/jour/article/view/1311 |
| _version_ | 1811189276882239488 |
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| author | L. P. Sizyakina A. I. Sergeeva I. I. Andreeva |
| author_facet | L. P. Sizyakina A. I. Sergeeva I. I. Andreeva |
| author_sort | L. P. Sizyakina |
| collection | DOAJ |
| description | Objective. The study aimed to assess the dynamics of the systemic immune response in patients during mesotherapy with hyaluronic acid (HA).Materials and methods. The observation group included 26 women who received the first-time mesocorrection with drugs based on hyaluronic acid (HA). Injections of low molecular weight HA were carried out according to standard methods in a course of 5 procedures with an interval of 14 days. The parameters of the innate and adaptive immune response were studied before and two weeks after the end of the course. The skin condition was assessed by dermatoscopy (Aramo Smart Lite 300, Southern Korea).Results. The clinical effect of the course of procedures was reflected in the subjective improvement in the appearance. The improvement was confirmed by hardware analysis, which recorded an increase in hydration, a smoothing of the skin relief, and a decrease in the depth of wrinkles. At the end of the course, redistribution of lymphocyte populations towards natural killer cells and B-lymphocytes was revealed with a decrease in the total number of T cells. The antibody production of immunoglobulins of classes M and G was increased, the serum content of Ig A and IgE was reduced, the number of both T-effectors and T-lymphocytes with immunosuppressive activity increased. Changes in the neutrophil system were characterized by the inhibition of the production of reactive oxygen intermediates; the dynamics of the expression of Toll-like receptors by monocytes was ambiguous.Conclusion. The results of the study confirmed the active involvement of the factors of innate and adaptive systemic response in the cosmetic effect, which manifested itself immediately after mesotherapy as systemic dysregulatory immune changes. |
| first_indexed | 2024-04-11T14:32:08Z |
| format | Article |
| id | doaj.art-91a39c3c452347a898cee7b1a5ee1637 |
| institution | Directory Open Access Journal |
| issn | 2219-8075 2618-7876 |
| language | English |
| last_indexed | 2024-04-11T14:32:08Z |
| publishDate | 2021-03-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Медицинский вестник Юга России |
| spelling | doaj.art-91a39c3c452347a898cee7b1a5ee16372022-12-22T04:18:30ZengState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationМедицинский вестник Юга России2219-80752618-78762021-03-01121687310.21886/2219-8075-2021-12-1-68-73793Discoordination of the processes of activation and suppression of immunocompetent cells during mesotherapy with hyaluronic acidL. P. Sizyakina0A. I. Sergeeva1I. I. Andreeva2Rostov State Medical UniversityRostov State Medical UniversityRostov State Medical UniversityObjective. The study aimed to assess the dynamics of the systemic immune response in patients during mesotherapy with hyaluronic acid (HA).Materials and methods. The observation group included 26 women who received the first-time mesocorrection with drugs based on hyaluronic acid (HA). Injections of low molecular weight HA were carried out according to standard methods in a course of 5 procedures with an interval of 14 days. The parameters of the innate and adaptive immune response were studied before and two weeks after the end of the course. The skin condition was assessed by dermatoscopy (Aramo Smart Lite 300, Southern Korea).Results. The clinical effect of the course of procedures was reflected in the subjective improvement in the appearance. The improvement was confirmed by hardware analysis, which recorded an increase in hydration, a smoothing of the skin relief, and a decrease in the depth of wrinkles. At the end of the course, redistribution of lymphocyte populations towards natural killer cells and B-lymphocytes was revealed with a decrease in the total number of T cells. The antibody production of immunoglobulins of classes M and G was increased, the serum content of Ig A and IgE was reduced, the number of both T-effectors and T-lymphocytes with immunosuppressive activity increased. Changes in the neutrophil system were characterized by the inhibition of the production of reactive oxygen intermediates; the dynamics of the expression of Toll-like receptors by monocytes was ambiguous.Conclusion. The results of the study confirmed the active involvement of the factors of innate and adaptive systemic response in the cosmetic effect, which manifested itself immediately after mesotherapy as systemic dysregulatory immune changes.https://www.medicalherald.ru/jour/article/view/1311hyaluronic acidinnate and adaptive immune responsemesotherapy |
| spellingShingle | L. P. Sizyakina A. I. Sergeeva I. I. Andreeva Discoordination of the processes of activation and suppression of immunocompetent cells during mesotherapy with hyaluronic acid Медицинский вестник Юга России hyaluronic acid innate and adaptive immune response mesotherapy |
| title | Discoordination of the processes of activation and suppression of immunocompetent cells during mesotherapy with hyaluronic acid |
| title_full | Discoordination of the processes of activation and suppression of immunocompetent cells during mesotherapy with hyaluronic acid |
| title_fullStr | Discoordination of the processes of activation and suppression of immunocompetent cells during mesotherapy with hyaluronic acid |
| title_full_unstemmed | Discoordination of the processes of activation and suppression of immunocompetent cells during mesotherapy with hyaluronic acid |
| title_short | Discoordination of the processes of activation and suppression of immunocompetent cells during mesotherapy with hyaluronic acid |
| title_sort | discoordination of the processes of activation and suppression of immunocompetent cells during mesotherapy with hyaluronic acid |
| topic | hyaluronic acid innate and adaptive immune response mesotherapy |
| url | https://www.medicalherald.ru/jour/article/view/1311 |
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