Massive retinal gliosis: An unusual case with immunohistochemical study
Massive retinal gliosis (MRG) is a rare, benign intraocular condition that results from the proliferation of well-differentiated glial cells. Immunohistochemically, these cells show positivity for glial fibrillary acid protein (GFAP), neuron specific enolase (NSE), and S-100 protein. We encountered...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2011;volume=59;issue=3;spage=246;epage=248;aulast=Deshmukh |
| _version_ | 1819020013563019264 |
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| author | Sanjay D Deshmukh Amrut V Ashturkar Shridhar V Babanagare Suvarna K Gokhale Anand A Deshpande |
| author_facet | Sanjay D Deshmukh Amrut V Ashturkar Shridhar V Babanagare Suvarna K Gokhale Anand A Deshpande |
| author_sort | Sanjay D Deshmukh |
| collection | DOAJ |
| description | Massive retinal gliosis (MRG) is a rare, benign intraocular condition that results from the proliferation of well-differentiated glial cells. Immunohistochemically, these cells show positivity for glial fibrillary acid protein (GFAP), neuron specific enolase (NSE), and S-100 protein. We encountered a case of a 45-year-old female with loss of vision in the left eye. She had a history of trauma to that eye two years ago. Enucleation was carried out, because malignancy was suspected due to retinal calcification. On the basis of light microscopy and immunohistochemistry (IHC) performed on the enucleated eye, it was diagnosed as massive retinal gliosis. |
| first_indexed | 2024-12-21T03:44:27Z |
| format | Article |
| id | doaj.art-91a401669ed4412a98fa2732e2600e51 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-21T03:44:27Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-91a401669ed4412a98fa2732e2600e512022-12-21T19:17:08ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892011-01-0159324624810.4103/0301-4738.81050Massive retinal gliosis: An unusual case with immunohistochemical studySanjay D DeshmukhAmrut V AshturkarShridhar V BabanagareSuvarna K GokhaleAnand A DeshpandeMassive retinal gliosis (MRG) is a rare, benign intraocular condition that results from the proliferation of well-differentiated glial cells. Immunohistochemically, these cells show positivity for glial fibrillary acid protein (GFAP), neuron specific enolase (NSE), and S-100 protein. We encountered a case of a 45-year-old female with loss of vision in the left eye. She had a history of trauma to that eye two years ago. Enucleation was carried out, because malignancy was suspected due to retinal calcification. On the basis of light microscopy and immunohistochemistry (IHC) performed on the enucleated eye, it was diagnosed as massive retinal gliosis.http://www.ijo.in/article.asp?issn=0301-4738;year=2011;volume=59;issue=3;spage=246;epage=248;aulast=DeshmukhAhmed glaucoma valvehypotonypost-penetrating-keratoplasty glaucomatube extrusionscleral patchRanibizumabbevacizumabchoroidal neovascular membraneage-related macular degenerationintravitreal injectioncentral macular thicknessbest corrected visual acuityIntravitreal injectionmethotrexatepharmacokineticsContrast sensitivitydiabetesglarepupil cycle timeAnemiadiabetic retinopathymicroalbuminuriaseverityObjective Structured Clinical ExaminationophthalmologyundergraduateAnisometropiaanisometropic amblyopiafusionstereopsisTraumatic cataractBirmingham Eye Trauma Terminology SystemIndiacataract surgeryChildren with learning disabilityocular disordersrefractive errorsspecial needsCharles Bonnet syndromedementiahallucinationspregabalinOcular surface reconstructionSteven-Johnson syndromesuperficial keratectomyChoroidal melanomahard exudateslipid exudationDonor scleraglobe rupturescleral patch graftEyelidMiragelretinal detachmentscleral buckleAngiitisBehcet diseaseneuroretinitisBevacizumabchoroidal neovascularizationintravitreal injectionmyopiaphotodynamic therapyranibizumabtriamcinolone acetonidevascular endothelial growth factorEnucleationimmunohistochemistrymassive retinal gliosis |
| spellingShingle | Sanjay D Deshmukh Amrut V Ashturkar Shridhar V Babanagare Suvarna K Gokhale Anand A Deshpande Massive retinal gliosis: An unusual case with immunohistochemical study Indian Journal of Ophthalmology Ahmed glaucoma valve hypotony post-penetrating-keratoplasty glaucoma tube extrusion scleral patch Ranibizumab bevacizumab choroidal neovascular membrane age-related macular degeneration intravitreal injection central macular thickness best corrected visual acuity Intravitreal injection methotrexate pharmacokinetics Contrast sensitivity diabetes glare pupil cycle time Anemia diabetic retinopathy microalbuminuria severity Objective Structured Clinical Examination ophthalmology undergraduate Anisometropia anisometropic amblyopia fusion stereopsis Traumatic cataract Birmingham Eye Trauma Terminology System India cataract surgery Children with learning disability ocular disorders refractive errors special needs Charles Bonnet syndrome dementia hallucinations pregabalin Ocular surface reconstruction Steven-Johnson syndrome superficial keratectomy Choroidal melanoma hard exudates lipid exudation Donor sclera globe rupture scleral patch graft Eyelid Miragel retinal detachment scleral buckle Angiitis Behcet disease neuroretinitis Bevacizumab choroidal neovascularization intravitreal injection myopia photodynamic therapy ranibizumab triamcinolone acetonide vascular endothelial growth factor Enucleation immunohistochemistry massive retinal gliosis |
| title | Massive retinal gliosis: An unusual case with immunohistochemical study |
| title_full | Massive retinal gliosis: An unusual case with immunohistochemical study |
| title_fullStr | Massive retinal gliosis: An unusual case with immunohistochemical study |
| title_full_unstemmed | Massive retinal gliosis: An unusual case with immunohistochemical study |
| title_short | Massive retinal gliosis: An unusual case with immunohistochemical study |
| title_sort | massive retinal gliosis an unusual case with immunohistochemical study |
| topic | Ahmed glaucoma valve hypotony post-penetrating-keratoplasty glaucoma tube extrusion scleral patch Ranibizumab bevacizumab choroidal neovascular membrane age-related macular degeneration intravitreal injection central macular thickness best corrected visual acuity Intravitreal injection methotrexate pharmacokinetics Contrast sensitivity diabetes glare pupil cycle time Anemia diabetic retinopathy microalbuminuria severity Objective Structured Clinical Examination ophthalmology undergraduate Anisometropia anisometropic amblyopia fusion stereopsis Traumatic cataract Birmingham Eye Trauma Terminology System India cataract surgery Children with learning disability ocular disorders refractive errors special needs Charles Bonnet syndrome dementia hallucinations pregabalin Ocular surface reconstruction Steven-Johnson syndrome superficial keratectomy Choroidal melanoma hard exudates lipid exudation Donor sclera globe rupture scleral patch graft Eyelid Miragel retinal detachment scleral buckle Angiitis Behcet disease neuroretinitis Bevacizumab choroidal neovascularization intravitreal injection myopia photodynamic therapy ranibizumab triamcinolone acetonide vascular endothelial growth factor Enucleation immunohistochemistry massive retinal gliosis |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2011;volume=59;issue=3;spage=246;epage=248;aulast=Deshmukh |
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