Improved acquisition of contact heat evoked potentials with increased heating ramp
Abstract Contact heat evoked potentials (CHEPs) represent an objective and non-invasive measure to investigate the integrity of the nociceptive neuraxis. The clinical value of CHEPs is mostly reflected in improved diagnosis of peripheral neuropathies and spinal lesions. One of the limitations of con...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-04867-y |
| _version_ | 1818954720116473856 |
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| author | I. De Schoenmacker J. Archibald J. L. K. Kramer M. Hubli |
| author_facet | I. De Schoenmacker J. Archibald J. L. K. Kramer M. Hubli |
| author_sort | I. De Schoenmacker |
| collection | DOAJ |
| description | Abstract Contact heat evoked potentials (CHEPs) represent an objective and non-invasive measure to investigate the integrity of the nociceptive neuraxis. The clinical value of CHEPs is mostly reflected in improved diagnosis of peripheral neuropathies and spinal lesions. One of the limitations of conventional contact heat stimulation is the relatively slow heating ramp (70 °C/s). This is thought to create a problem of desynchronized evoked responses in the brain, particularly after stimulation in the feet. Recent technological advancements allow for an increased heating ramp of contact heat stimulation, however, to what extent these improve the acquisition of evoked potentials is still unknown. In the current study, 30 healthy subjects were stimulated with contact heat at the hand and foot with four different heating ramps (i.e., 150 °C/s, 200 °C/s, 250 °C/s, and 300 °C/s) to a peak temperature of 60 °C. We examined changes in amplitude, latency, and signal-to-noise ratio (SNR) of the vertex (N2-P2) waveforms. Faster heating ramps decreased CHEP latency for hand and foot stimulation (hand: F = 18.41, p < 0.001; foot: F = 4.19, p = 0.009). Following stimulation of the foot only, faster heating ramps increased SNR (F = 3.32, p = 0.024) and N2 amplitude (F = 4.38, p = 0.007). Our findings suggest that clinical applications of CHEPs should consider adopting faster heating ramps up to 250 °C/s. The improved acquisition of CHEPs might consequently reduce false negative results in clinical cohorts. From a physiological perspective, our results demonstrate the importance of peripherally synchronizing afferents recruitment to satisfactorily acquire CHEPs. |
| first_indexed | 2024-12-20T10:26:39Z |
| format | Article |
| id | doaj.art-91a54b704a9a4397818d369a2f455a32 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T10:26:39Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-91a54b704a9a4397818d369a2f455a322022-12-21T19:43:49ZengNature PortfolioScientific Reports2045-23222022-01-0112111110.1038/s41598-022-04867-yImproved acquisition of contact heat evoked potentials with increased heating rampI. De Schoenmacker0J. Archibald1J. L. K. Kramer2M. Hubli3Spinal Cord Injury Center, Balgrist University Hospital, University of ZurichDepartment of Experimental Medicine, University of British ColumbiaInternational Collaboration on Repair Discoveries (ICORD), University of British ColumbiaSpinal Cord Injury Center, Balgrist University Hospital, University of ZurichAbstract Contact heat evoked potentials (CHEPs) represent an objective and non-invasive measure to investigate the integrity of the nociceptive neuraxis. The clinical value of CHEPs is mostly reflected in improved diagnosis of peripheral neuropathies and spinal lesions. One of the limitations of conventional contact heat stimulation is the relatively slow heating ramp (70 °C/s). This is thought to create a problem of desynchronized evoked responses in the brain, particularly after stimulation in the feet. Recent technological advancements allow for an increased heating ramp of contact heat stimulation, however, to what extent these improve the acquisition of evoked potentials is still unknown. In the current study, 30 healthy subjects were stimulated with contact heat at the hand and foot with four different heating ramps (i.e., 150 °C/s, 200 °C/s, 250 °C/s, and 300 °C/s) to a peak temperature of 60 °C. We examined changes in amplitude, latency, and signal-to-noise ratio (SNR) of the vertex (N2-P2) waveforms. Faster heating ramps decreased CHEP latency for hand and foot stimulation (hand: F = 18.41, p < 0.001; foot: F = 4.19, p = 0.009). Following stimulation of the foot only, faster heating ramps increased SNR (F = 3.32, p = 0.024) and N2 amplitude (F = 4.38, p = 0.007). Our findings suggest that clinical applications of CHEPs should consider adopting faster heating ramps up to 250 °C/s. The improved acquisition of CHEPs might consequently reduce false negative results in clinical cohorts. From a physiological perspective, our results demonstrate the importance of peripherally synchronizing afferents recruitment to satisfactorily acquire CHEPs.https://doi.org/10.1038/s41598-022-04867-y |
| spellingShingle | I. De Schoenmacker J. Archibald J. L. K. Kramer M. Hubli Improved acquisition of contact heat evoked potentials with increased heating ramp Scientific Reports |
| title | Improved acquisition of contact heat evoked potentials with increased heating ramp |
| title_full | Improved acquisition of contact heat evoked potentials with increased heating ramp |
| title_fullStr | Improved acquisition of contact heat evoked potentials with increased heating ramp |
| title_full_unstemmed | Improved acquisition of contact heat evoked potentials with increased heating ramp |
| title_short | Improved acquisition of contact heat evoked potentials with increased heating ramp |
| title_sort | improved acquisition of contact heat evoked potentials with increased heating ramp |
| url | https://doi.org/10.1038/s41598-022-04867-y |
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