ALPHA-FETOPROTEIN AS ANTI-AGING AGENT: EFFECT ON SURVIVAL AND AGE-MARKERS IN MICE
Alpha-fetoprotein is one of the best known embriospecific proteins, which is used to diagnose fetal abnormalities and tumor processes of the gastrointestinal tract and liver and has a pronounced immunotropic and detoxifying effect, and also a direct apoptotic effect on tumor cells. The appointment o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Peoples’ Friendship University of Russia (RUDN University)
2016-12-01
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| Series: | RUDN Journal of Ecology and Life Safety |
| Subjects: | |
| Online Access: | https://journals.rudn.ru/ecology/article/viewFile/12910/12340 |
| _version_ | 1818248905307979776 |
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| author | V I Dontsov V N Krut’ko A Ya Chizhov |
| author_facet | V I Dontsov V N Krut’ko A Ya Chizhov |
| author_sort | V I Dontsov |
| collection | DOAJ |
| description | Alpha-fetoprotein is one of the best known embriospecific proteins, which is used to diagnose fetal abnormalities and tumor processes of the gastrointestinal tract and liver and has a pronounced immunotropic and detoxifying effect, and also a direct apoptotic effect on tumor cells. The appointment of AFP mice at the oldest age in our experiments, dramatically increased survival and markedly increased the relative weight immunotropic bodies, apparently, due to the characteristic of the AFP general effect of improving the functions of tissues and detoxifying action. Thus, AFP has a significant bioactivity and anti-aging effectname, that allows to consider it as a candidate for a geroprotective agent. |
| first_indexed | 2024-12-12T15:28:01Z |
| format | Article |
| id | doaj.art-91a64a99333f4aea8afacf0f645fe369 |
| institution | Directory Open Access Journal |
| issn | 2313-2310 2408-8919 |
| language | English |
| last_indexed | 2024-12-12T15:28:01Z |
| publishDate | 2016-12-01 |
| publisher | Peoples’ Friendship University of Russia (RUDN University) |
| record_format | Article |
| series | RUDN Journal of Ecology and Life Safety |
| spelling | doaj.art-91a64a99333f4aea8afacf0f645fe3692022-12-22T00:20:12ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Ecology and Life Safety2313-23102408-89192016-12-010211011712909ALPHA-FETOPROTEIN AS ANTI-AGING AGENT: EFFECT ON SURVIVAL AND AGE-MARKERS IN MICEV I Dontsov0V N Krut’ko1A Ya Chizhov2Laboratory of Systems Analysis and Information Technologies in Medicine and Ecology, Federal Research Center«Informatics and Management» of the Russian Academy of SciencesLaboratory of Systems Analysis and Information Technologies in Medicine and Ecology, Federal Research Center«Informatics and Management» of the Russian Academy of SciencesPeoples’ Friendship University of RussiaAlpha-fetoprotein is one of the best known embriospecific proteins, which is used to diagnose fetal abnormalities and tumor processes of the gastrointestinal tract and liver and has a pronounced immunotropic and detoxifying effect, and also a direct apoptotic effect on tumor cells. The appointment of AFP mice at the oldest age in our experiments, dramatically increased survival and markedly increased the relative weight immunotropic bodies, apparently, due to the characteristic of the AFP general effect of improving the functions of tissues and detoxifying action. Thus, AFP has a significant bioactivity and anti-aging effectname, that allows to consider it as a candidate for a geroprotective agent.https://journals.rudn.ru/ecology/article/viewFile/12910/12340biomarkers of agingmiceimmune statusalpha-fetoproteinautoimmune aggressiongeroprophylaxis |
| spellingShingle | V I Dontsov V N Krut’ko A Ya Chizhov ALPHA-FETOPROTEIN AS ANTI-AGING AGENT: EFFECT ON SURVIVAL AND AGE-MARKERS IN MICE RUDN Journal of Ecology and Life Safety biomarkers of aging mice immune status alpha-fetoprotein autoimmune aggression geroprophylaxis |
| title | ALPHA-FETOPROTEIN AS ANTI-AGING AGENT: EFFECT ON SURVIVAL AND AGE-MARKERS IN MICE |
| title_full | ALPHA-FETOPROTEIN AS ANTI-AGING AGENT: EFFECT ON SURVIVAL AND AGE-MARKERS IN MICE |
| title_fullStr | ALPHA-FETOPROTEIN AS ANTI-AGING AGENT: EFFECT ON SURVIVAL AND AGE-MARKERS IN MICE |
| title_full_unstemmed | ALPHA-FETOPROTEIN AS ANTI-AGING AGENT: EFFECT ON SURVIVAL AND AGE-MARKERS IN MICE |
| title_short | ALPHA-FETOPROTEIN AS ANTI-AGING AGENT: EFFECT ON SURVIVAL AND AGE-MARKERS IN MICE |
| title_sort | alpha fetoprotein as anti aging agent effect on survival and age markers in mice |
| topic | biomarkers of aging mice immune status alpha-fetoprotein autoimmune aggression geroprophylaxis |
| url | https://journals.rudn.ru/ecology/article/viewFile/12910/12340 |
| work_keys_str_mv | AT vidontsov alphafetoproteinasantiagingagenteffectonsurvivalandagemarkersinmice AT vnkrutko alphafetoproteinasantiagingagenteffectonsurvivalandagemarkersinmice AT ayachizhov alphafetoproteinasantiagingagenteffectonsurvivalandagemarkersinmice |