Automated quality control for genome wide association studies [version 1; referees: 1 approved, 2 approved with reservations]

This paper provides details on the necessary steps to assess and control data in genome wide association studies (GWAS) using genotype information on a large number of genetic markers for large number of individuals. Due to varied study designs and genotyping platforms between multiple sites/project...

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Bibliographic Details
Main Authors: Sally R. Ellingson, David W. Fardo
Format: Article
Language:English
Published: F1000 Research Ltd 2016-07-01
Series:F1000Research
Subjects:
Online Access:http://f1000research.com/articles/5-1889/v1
Description
Summary:This paper provides details on the necessary steps to assess and control data in genome wide association studies (GWAS) using genotype information on a large number of genetic markers for large number of individuals. Due to varied study designs and genotyping platforms between multiple sites/projects as well as potential genotyping errors, it is important to ensure high quality data. Scripts and directions are provided to facilitate others in this process.
ISSN:2046-1402