The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women
The aim of this study was to investigate the association between cardiorespiratory fitness and gut microbiota composition in premenopausal women. The participants consisted of 71 premenopausal Finnish women (aged 19–49 years). Gut microbiota were analyzed using flow cytometry, 16S rRNA gene hybridiz...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/9/8/792 |
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| author | Yifan Yang Yi Shi Petri Wiklund Xiao Tan Na Wu Xiaobo Zhang Olli Tikkanen Chenhong Zhang Eveliina Munukka Sulin Cheng |
| author_facet | Yifan Yang Yi Shi Petri Wiklund Xiao Tan Na Wu Xiaobo Zhang Olli Tikkanen Chenhong Zhang Eveliina Munukka Sulin Cheng |
| author_sort | Yifan Yang |
| collection | DOAJ |
| description | The aim of this study was to investigate the association between cardiorespiratory fitness and gut microbiota composition in premenopausal women. The participants consisted of 71 premenopausal Finnish women (aged 19–49 years). Gut microbiota were analyzed using flow cytometry, 16S rRNA gene hybridization and DNA-staining. Maximum oxygen uptake (VO2max) was assessed by respiratory gas analyzer and body composition by Bioimpdance. We found that participants with low VO2max had lower Bacteroides, but higher Eubacterium rectale-Clostridium coccoides than the high VO2max group (p < 0.05 for all). VO2max was inversely associated with EreC (r = −0.309, p = 0.01) but not with other bacteria. VO2max also negatively correlated with fat% (r = −0.755, p < 0.001), triglycerides (r = −0.274, p = 0.021) and leptin (r = −0.574, p < 0.001). By contrast, EreC was positively associated with fat% (r = 0.382, p = 0.002), dietary fat intake (r = 0.258, p = 0.034), triglycerides (r = 0.390, p = 0.002) and leptin (r = 0.424, p = 0.001), but negatively with carbohydrate intake (r = −0.252, p = 0.034) and HDL (r = −0.26, p = 0.028). After adjusting for age and dietary intake, all the significant associations remained. However, after adjusting for fat%, the associations between VO2max and EreC disappeared. Our results suggest that cardiorespiratory fitness is associated with gut microbiota composition, independent of age and carbohydrate or fat intake. The association between VO2max and EreC, however, appears to be mediated by body fatness. |
| first_indexed | 2024-04-13T07:31:31Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-04-13T07:31:31Z |
| publishDate | 2017-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-91aa756ac1ce407aaef64287864e64e02022-12-22T02:56:21ZengMDPI AGNutrients2072-66432017-07-019879210.3390/nu9080792nu9080792The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal WomenYifan Yang0Yi Shi1Petri Wiklund2Xiao Tan3Na Wu4Xiaobo Zhang5Olli Tikkanen6Chenhong Zhang7Eveliina Munukka8Sulin Cheng9School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, ChinaExercise, Health and Technology center, Shanghai Jiao Tong University, Shanghai 200240, ChinaExercise, Health and Technology center, Shanghai Jiao Tong University, Shanghai 200240, ChinaExercise, Health and Technology center, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, ChinaSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, ChinaState Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, ChinaDepartment of Medical Microbiology and Immunology, University of Turku, 20014 Turku, FinlandSchool of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, ChinaThe aim of this study was to investigate the association between cardiorespiratory fitness and gut microbiota composition in premenopausal women. The participants consisted of 71 premenopausal Finnish women (aged 19–49 years). Gut microbiota were analyzed using flow cytometry, 16S rRNA gene hybridization and DNA-staining. Maximum oxygen uptake (VO2max) was assessed by respiratory gas analyzer and body composition by Bioimpdance. We found that participants with low VO2max had lower Bacteroides, but higher Eubacterium rectale-Clostridium coccoides than the high VO2max group (p < 0.05 for all). VO2max was inversely associated with EreC (r = −0.309, p = 0.01) but not with other bacteria. VO2max also negatively correlated with fat% (r = −0.755, p < 0.001), triglycerides (r = −0.274, p = 0.021) and leptin (r = −0.574, p < 0.001). By contrast, EreC was positively associated with fat% (r = 0.382, p = 0.002), dietary fat intake (r = 0.258, p = 0.034), triglycerides (r = 0.390, p = 0.002) and leptin (r = 0.424, p = 0.001), but negatively with carbohydrate intake (r = −0.252, p = 0.034) and HDL (r = −0.26, p = 0.028). After adjusting for age and dietary intake, all the significant associations remained. However, after adjusting for fat%, the associations between VO2max and EreC disappeared. Our results suggest that cardiorespiratory fitness is associated with gut microbiota composition, independent of age and carbohydrate or fat intake. The association between VO2max and EreC, however, appears to be mediated by body fatness.https://www.mdpi.com/2072-6643/9/8/792exerciseVO2maxgut microbiotabody fatness |
| spellingShingle | Yifan Yang Yi Shi Petri Wiklund Xiao Tan Na Wu Xiaobo Zhang Olli Tikkanen Chenhong Zhang Eveliina Munukka Sulin Cheng The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women Nutrients exercise VO2max gut microbiota body fatness |
| title | The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women |
| title_full | The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women |
| title_fullStr | The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women |
| title_full_unstemmed | The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women |
| title_short | The Association between Cardiorespiratory Fitness and Gut Microbiota Composition in Premenopausal Women |
| title_sort | association between cardiorespiratory fitness and gut microbiota composition in premenopausal women |
| topic | exercise VO2max gut microbiota body fatness |
| url | https://www.mdpi.com/2072-6643/9/8/792 |
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