Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers: a systematic review
Abstract Whole-body vibration (WBV) and resistive vibration exercise (RVE) are utilized as countermeasures against bone loss, muscle wasting, and physical deconditioning. The safety of the interventions, in terms of the risk of inducing undesired blood clotting and venous thrombosis, is not clear. W...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-12-01
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| Series: | npj Microgravity |
| Online Access: | https://doi.org/10.1038/s41526-023-00338-4 |
| _version_ | 1797397823788941312 |
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| author | Lucrezia Zuccarelli Giovanni Baldassarre Andrew Winnard Katie M. Harris Tobias Weber David A. Green Lonnie G. Petersen Tovy Haber Kamine Lara Roberts David S. Kim Danielle K. Greaves Roopen Arya Jonathan M. Laws Antoine Elias Jörn Rittweger Bruno Grassi Nandu Goswami |
| author_facet | Lucrezia Zuccarelli Giovanni Baldassarre Andrew Winnard Katie M. Harris Tobias Weber David A. Green Lonnie G. Petersen Tovy Haber Kamine Lara Roberts David S. Kim Danielle K. Greaves Roopen Arya Jonathan M. Laws Antoine Elias Jörn Rittweger Bruno Grassi Nandu Goswami |
| author_sort | Lucrezia Zuccarelli |
| collection | DOAJ |
| description | Abstract Whole-body vibration (WBV) and resistive vibration exercise (RVE) are utilized as countermeasures against bone loss, muscle wasting, and physical deconditioning. The safety of the interventions, in terms of the risk of inducing undesired blood clotting and venous thrombosis, is not clear. We therefore performed the present systematic review of the available scientific literature on the issue. The review was conducted following the guidelines by the Space Biomedicine Systematic Review Group, based on Cochrane review guidelines. The relevant context or environment of the studies was “ground-based environment”; space analogs or diseased conditions were not included. The search retrieved 801 studies; 77 articles were selected for further consideration after an initial screening. Thirty-three studies met the inclusion criteria. The main variables related to blood markers involved angiogenic and endothelial factors, fibrinolysis and coagulation markers, cytokine levels, inflammatory and plasma oxidative stress markers. Functional and hemodynamic markers involved blood pressure measurements, systemic vascular resistance, blood flow and microvascular and endothelial functions. The available evidence suggests neutral or potentially positive effects of short- and long-term interventions with WBV and RVE on variables related to blood coagulation, fibrinolysis, inflammatory status, oxidative stress, cardiovascular, microvascular and endothelial functions. No significant warning signs towards an increased risk of undesired clotting and venous thrombosis were identified. If confirmed by further studies, WBV and RVE could be part of the countermeasures aimed at preventing or attenuating the muscular and cardiovascular deconditioning associated with spaceflights, permanence on planetary habitats and ground-based simulations of microgravity. |
| first_indexed | 2024-03-09T01:16:43Z |
| format | Article |
| id | doaj.art-91aae806cc5443dd88ef5c9f9747f653 |
| institution | Directory Open Access Journal |
| issn | 2373-8065 |
| language | English |
| last_indexed | 2024-03-09T01:16:43Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Microgravity |
| spelling | doaj.art-91aae806cc5443dd88ef5c9f9747f6532023-12-10T12:27:02ZengNature Portfolionpj Microgravity2373-80652023-12-019111810.1038/s41526-023-00338-4Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers: a systematic reviewLucrezia Zuccarelli0Giovanni Baldassarre1Andrew Winnard2Katie M. Harris3Tobias Weber4David A. Green5Lonnie G. Petersen6Tovy Haber Kamine7Lara Roberts8David S. Kim9Danielle K. Greaves10Roopen Arya11Jonathan M. Laws12Antoine Elias13Jörn Rittweger14Bruno Grassi15Nandu Goswami16Department of Medicine, University of UdineDepartment of Medicine, University of UdineSpace Biomedicine Systematic Review MethodsFaculty of Medicine, Memorial University of NewfoundlandSpace Medicine Team, European Astronaut Centre, European Space Agency (ESA)Space Medicine Team, European Astronaut Centre, European Space Agency (ESA)Department of Biomedical Sciences, University of CopenhagenDivision of Trauma, Acute Care Surgery, and Surgical Critical Care, Baystate Medical CenterKings College Hospital, NHS Foundation TrustSpace Medicine Team, European Astronaut Centre, European Space Agency (ESA)Department of Kinesiology and Health Sciences, Faculty of Health, University of WaterlooKings College Hospital, NHS Foundation TrustSpace Biomedicine Systematic Review MethodsDepartment of Vascular Medicine, Sainte Musse Hospital, Toulon La Seyne Hospital CentreInstitute of Aerospace Medicine, German Aerospace Center (DLR)Department of Medicine, University of UdineDivision of Physiology, Otto Löwi Research Center for Vascular Biology, Immunity and Inflammation, Medical University of GrazAbstract Whole-body vibration (WBV) and resistive vibration exercise (RVE) are utilized as countermeasures against bone loss, muscle wasting, and physical deconditioning. The safety of the interventions, in terms of the risk of inducing undesired blood clotting and venous thrombosis, is not clear. We therefore performed the present systematic review of the available scientific literature on the issue. The review was conducted following the guidelines by the Space Biomedicine Systematic Review Group, based on Cochrane review guidelines. The relevant context or environment of the studies was “ground-based environment”; space analogs or diseased conditions were not included. The search retrieved 801 studies; 77 articles were selected for further consideration after an initial screening. Thirty-three studies met the inclusion criteria. The main variables related to blood markers involved angiogenic and endothelial factors, fibrinolysis and coagulation markers, cytokine levels, inflammatory and plasma oxidative stress markers. Functional and hemodynamic markers involved blood pressure measurements, systemic vascular resistance, blood flow and microvascular and endothelial functions. The available evidence suggests neutral or potentially positive effects of short- and long-term interventions with WBV and RVE on variables related to blood coagulation, fibrinolysis, inflammatory status, oxidative stress, cardiovascular, microvascular and endothelial functions. No significant warning signs towards an increased risk of undesired clotting and venous thrombosis were identified. If confirmed by further studies, WBV and RVE could be part of the countermeasures aimed at preventing or attenuating the muscular and cardiovascular deconditioning associated with spaceflights, permanence on planetary habitats and ground-based simulations of microgravity.https://doi.org/10.1038/s41526-023-00338-4 |
| spellingShingle | Lucrezia Zuccarelli Giovanni Baldassarre Andrew Winnard Katie M. Harris Tobias Weber David A. Green Lonnie G. Petersen Tovy Haber Kamine Lara Roberts David S. Kim Danielle K. Greaves Roopen Arya Jonathan M. Laws Antoine Elias Jörn Rittweger Bruno Grassi Nandu Goswami Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers: a systematic review npj Microgravity |
| title | Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers: a systematic review |
| title_full | Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers: a systematic review |
| title_fullStr | Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers: a systematic review |
| title_full_unstemmed | Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers: a systematic review |
| title_short | Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers: a systematic review |
| title_sort | effects of whole body vibration or resistive vibration exercise on blood clotting and related biomarkers a systematic review |
| url | https://doi.org/10.1038/s41526-023-00338-4 |
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