Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells
MXenes with a two-dimensional (2D) structure have attracted attention as potential biomedical materials. In this study, Ti<sub>3</sub>C<sub>2</sub> MXene particles with 2D-lamellar structures were intercalated and their potential as a biomaterial was evaluated using human mes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/14/16/4453 |
| _version_ | 1797523144756428800 |
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| author | Jun-Hwee Jang Eun-Jung Lee |
| author_facet | Jun-Hwee Jang Eun-Jung Lee |
| author_sort | Jun-Hwee Jang |
| collection | DOAJ |
| description | MXenes with a two-dimensional (2D) structure have attracted attention as potential biomedical materials. In this study, Ti<sub>3</sub>C<sub>2</sub> MXene particles with 2D-lamellar structures were intercalated and their potential as a biomaterial was evaluated using human mesenchymal stem cells. Intercalated MXene was characterized in terms of microstructure, phase composition, and size. Cell proliferation experiments with MXene particles confirmed that concentrations >50 μg/mL were cytotoxic, while concentrations <20 μg/mL promoted osteogenic differentiation. Moreover, MXene effectively facilitated the early and late osteogenic gene expression. |
| first_indexed | 2024-03-10T08:39:13Z |
| format | Article |
| id | doaj.art-91acbc77c2c24afeb29a31964eea49ef |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T08:39:13Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-91acbc77c2c24afeb29a31964eea49ef2023-11-22T08:27:44ZengMDPI AGMaterials1996-19442021-08-011416445310.3390/ma14164453Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem CellsJun-Hwee Jang0Eun-Jung Lee1Department of Nano-Biomedical Science, BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, KoreaDepartment of Nano-Biomedical Science, BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, KoreaMXenes with a two-dimensional (2D) structure have attracted attention as potential biomedical materials. In this study, Ti<sub>3</sub>C<sub>2</sub> MXene particles with 2D-lamellar structures were intercalated and their potential as a biomaterial was evaluated using human mesenchymal stem cells. Intercalated MXene was characterized in terms of microstructure, phase composition, and size. Cell proliferation experiments with MXene particles confirmed that concentrations >50 μg/mL were cytotoxic, while concentrations <20 μg/mL promoted osteogenic differentiation. Moreover, MXene effectively facilitated the early and late osteogenic gene expression.https://www.mdpi.com/1996-1944/14/16/4453MXeneintercalationtwo-dimensionalstacked-lamellarosteogenic differentiation |
| spellingShingle | Jun-Hwee Jang Eun-Jung Lee Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells Materials MXene intercalation two-dimensional stacked-lamellar osteogenic differentiation |
| title | Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells |
| title_full | Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells |
| title_fullStr | Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells |
| title_full_unstemmed | Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells |
| title_short | Influence of MXene Particles with a Stacked-Lamellar Structure on Osteogenic Differentiation of Human Mesenchymal Stem Cells |
| title_sort | influence of mxene particles with a stacked lamellar structure on osteogenic differentiation of human mesenchymal stem cells |
| topic | MXene intercalation two-dimensional stacked-lamellar osteogenic differentiation |
| url | https://www.mdpi.com/1996-1944/14/16/4453 |
| work_keys_str_mv | AT junhweejang influenceofmxeneparticleswithastackedlamellarstructureonosteogenicdifferentiationofhumanmesenchymalstemcells AT eunjunglee influenceofmxeneparticleswithastackedlamellarstructureonosteogenicdifferentiationofhumanmesenchymalstemcells |