The Presence of Periodontitis Exacerbates Non-Alcoholic Fatty Liver Disease via Sphingolipid Metabolism-Associated Insulin Resistance and Hepatic Inflammation in Mice with Metabolic Syndrome

The Presence of Periodontitis Exacerbates Non-Alcoholic Fatty Liver Disease via Sphingolipid Metabolism-Associated Insulin Resistance and Hepatic Inflammation in Mice with Metabolic Syndrome

Clinical studies have shown that periodontitis is associated with non-alcoholic fatty liver disease (NAFLD). However, it remains unclear if periodontitis contributes to the progression of NAFLD. In this study, we generated a mouse model with high-fat diet (HFD)-induced metabolic syndrome (MetS) and...

Full description

Bibliographic Details
Main Authors: Zhongyang Lu, Yanchun Li, Nityananda Chowdhury, Hong Yu, Wing-Kin Syn, Maria Lopes-Virella, Özlem Yilmaz, Yan Huang
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
metabolic syndrome
periodontitis
non-alcoholic fatty liver disease
imipramine
acid sphingomyelinase
inflammation
Online Access:https://www.mdpi.com/1422-0067/24/9/8322

Similar Items

Similar Items