Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators
Sirtuins (SIRTs), enzymes from the family of NAD<sup>+</sup>-dependent histone deacetylases, play an important role in the functioning of the body at the cellular level and participate in many biochemical processes. The multi-directionality of SIRTs encourages scientists to undertake res...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/2/630 |
| _version_ | 1797413463351361536 |
|---|---|
| author | Ewa Maria Kratz Katarzyna Sołkiewicz Adriana Kubis-Kubiak Agnieszka Piwowar |
| author_facet | Ewa Maria Kratz Katarzyna Sołkiewicz Adriana Kubis-Kubiak Agnieszka Piwowar |
| author_sort | Ewa Maria Kratz |
| collection | DOAJ |
| description | Sirtuins (SIRTs), enzymes from the family of NAD<sup>+</sup>-dependent histone deacetylases, play an important role in the functioning of the body at the cellular level and participate in many biochemical processes. The multi-directionality of SIRTs encourages scientists to undertake research aimed at understanding the mechanisms of their action and the influence that SIRTs have on the organism. At the same time, new substances are constantly being sought that can modulate the action of SIRTs. Extensive research on the expression of SIRTs in various pathological conditions suggests that regulation of their activity may have positive results in supporting the treatment of certain metabolic, neurodegenerative or cancer diseases or this connected with oxidative stress. Due to such a wide spectrum of activity, SIRTs may also be a prognostic markers of selected pathological conditions and prove helpful in assessing their progression, especially by modulating their activity. The article presents and discusses the activating or inhibiting impact of individual SIRTs modulators. The review also gathered selected currently available information on the expression of SIRTs in individual disease cases as well as the biological role that SIRTs play in the human organism, also in connection with oxidative stress condition, taking into account the progress of knowledge about SIRTs over the years, with particular reference to the latest research results. |
| first_indexed | 2024-03-09T05:19:19Z |
| format | Article |
| id | doaj.art-91adef611e894a05a3f6663d4768f923 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:19:19Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-91adef611e894a05a3f6663d4768f9232023-12-03T12:42:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-01-0122263010.3390/ijms22020630Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity ModulatorsEwa Maria Kratz0Katarzyna Sołkiewicz1Adriana Kubis-Kubiak2Agnieszka Piwowar3Department of Laboratory Diagnostics, Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Laboratory Diagnostics, Division of Laboratory Diagnostics, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Toxicology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Toxicology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, PolandSirtuins (SIRTs), enzymes from the family of NAD<sup>+</sup>-dependent histone deacetylases, play an important role in the functioning of the body at the cellular level and participate in many biochemical processes. The multi-directionality of SIRTs encourages scientists to undertake research aimed at understanding the mechanisms of their action and the influence that SIRTs have on the organism. At the same time, new substances are constantly being sought that can modulate the action of SIRTs. Extensive research on the expression of SIRTs in various pathological conditions suggests that regulation of their activity may have positive results in supporting the treatment of certain metabolic, neurodegenerative or cancer diseases or this connected with oxidative stress. Due to such a wide spectrum of activity, SIRTs may also be a prognostic markers of selected pathological conditions and prove helpful in assessing their progression, especially by modulating their activity. The article presents and discusses the activating or inhibiting impact of individual SIRTs modulators. The review also gathered selected currently available information on the expression of SIRTs in individual disease cases as well as the biological role that SIRTs play in the human organism, also in connection with oxidative stress condition, taking into account the progress of knowledge about SIRTs over the years, with particular reference to the latest research results.https://www.mdpi.com/1422-0067/22/2/630sirtuins expressionsirtuin activatorssirtuin inhibitorssirtuins in pathological conditionsoxidative stress |
| spellingShingle | Ewa Maria Kratz Katarzyna Sołkiewicz Adriana Kubis-Kubiak Agnieszka Piwowar Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators International Journal of Molecular Sciences sirtuins expression sirtuin activators sirtuin inhibitors sirtuins in pathological conditions oxidative stress |
| title | Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators |
| title_full | Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators |
| title_fullStr | Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators |
| title_full_unstemmed | Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators |
| title_short | Sirtuins as Important Factors in Pathological States and the Role of Their Molecular Activity Modulators |
| title_sort | sirtuins as important factors in pathological states and the role of their molecular activity modulators |
| topic | sirtuins expression sirtuin activators sirtuin inhibitors sirtuins in pathological conditions oxidative stress |
| url | https://www.mdpi.com/1422-0067/22/2/630 |
| work_keys_str_mv | AT ewamariakratz sirtuinsasimportantfactorsinpathologicalstatesandtheroleoftheirmolecularactivitymodulators AT katarzynasołkiewicz sirtuinsasimportantfactorsinpathologicalstatesandtheroleoftheirmolecularactivitymodulators AT adrianakubiskubiak sirtuinsasimportantfactorsinpathologicalstatesandtheroleoftheirmolecularactivitymodulators AT agnieszkapiwowar sirtuinsasimportantfactorsinpathologicalstatesandtheroleoftheirmolecularactivitymodulators |