Probiotics Interact With Lipids Metabolism and Affect Gut Health
Probiotics have attracted much attention due to their ability to modulate host intestinal microbe, participate in nutrient metabolism or immunomodulatory. Both inflammatory bowel disease (IBD) and bowel cancer are digestive system disease, which have become a global public health problem due to thei...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.917043/full |
| _version_ | 1828199328135512064 |
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| author | Taoying Wu Taoying Wu Guangqiang Wang Zhiqiang Xiong Yongjun Xia Xin Song Hui Zhang Yan Wu Lianzhong Ai |
| author_facet | Taoying Wu Taoying Wu Guangqiang Wang Zhiqiang Xiong Yongjun Xia Xin Song Hui Zhang Yan Wu Lianzhong Ai |
| author_sort | Taoying Wu |
| collection | DOAJ |
| description | Probiotics have attracted much attention due to their ability to modulate host intestinal microbe, participate in nutrient metabolism or immunomodulatory. Both inflammatory bowel disease (IBD) and bowel cancer are digestive system disease, which have become a global public health problem due to their unclear etiology, difficult to cure, and repeated attacks. Disturbed gut microbiota and abnormal lipid metabolism would increase the risk of intestinal inflammation. However, the link between lipid metabolism, probiotics, and IBD is unclear. In this review, we found that different lipids and their derivatives have different effects on IBD and gut microbes. ω-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic acid, eicosapentaenoic acid, and their derivatives resolvin E1, resolvin D can inhibit oxidative stress and reactive oxygen species activate NFκB and MAPk pathway. While ω-6 PUFAs linoleic acid and arachidonic acid can be derived into leukotrienes and prostaglandins, which will aggravate IBD. Cholesterol can be converted into bile acids to promote lipid absorption and affect microbial survival and colonization. At the same time, it is affected by microbial bile salt hydrolase to regulate blood lipids. Low denstiy lipoprotein (LDL) is easily converted into oxidized LDL, thereby promoting inflammation, while high denstiy lipoprotein (HDL) has the opposite effect. Probiotics compete with intestinal microorganisms for nutrients or ecological sites and thus affect the structure of intestinal microbiota. Moreover, microbial short chain fatty acids, bile salt hydrolase, superoxide dismutase, glutathione, etc. can affect lipid metabolism and IBD. In conclusion, probiotics are directly or indirectly involved in lipids metabolism and their impact on IBD, which provides the possibility to explore the role of probiotics in improving gut health. |
| first_indexed | 2024-04-12T10:53:35Z |
| format | Article |
| id | doaj.art-91ae59933d344d74b541e712ffedb647 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-04-12T10:53:35Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-91ae59933d344d74b541e712ffedb6472022-12-22T03:36:10ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-05-01910.3389/fnut.2022.917043917043Probiotics Interact With Lipids Metabolism and Affect Gut HealthTaoying Wu0Taoying Wu1Guangqiang Wang2Zhiqiang Xiong3Yongjun Xia4Xin Song5Hui Zhang6Yan Wu7Lianzhong Ai8Shanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaHunan Key Laboratory of Bean Products Processing and Safety Control, School of Food and Chemical Engineering, Shaoyang University, Shaoyang, ChinaShanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaShanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaShanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaShanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaShanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaDepartment of Food Science and Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Engineering Research Center of Food Microbiology, School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, ChinaProbiotics have attracted much attention due to their ability to modulate host intestinal microbe, participate in nutrient metabolism or immunomodulatory. Both inflammatory bowel disease (IBD) and bowel cancer are digestive system disease, which have become a global public health problem due to their unclear etiology, difficult to cure, and repeated attacks. Disturbed gut microbiota and abnormal lipid metabolism would increase the risk of intestinal inflammation. However, the link between lipid metabolism, probiotics, and IBD is unclear. In this review, we found that different lipids and their derivatives have different effects on IBD and gut microbes. ω-3 polyunsaturated fatty acids (PUFAs) docosahexaenoic acid, eicosapentaenoic acid, and their derivatives resolvin E1, resolvin D can inhibit oxidative stress and reactive oxygen species activate NFκB and MAPk pathway. While ω-6 PUFAs linoleic acid and arachidonic acid can be derived into leukotrienes and prostaglandins, which will aggravate IBD. Cholesterol can be converted into bile acids to promote lipid absorption and affect microbial survival and colonization. At the same time, it is affected by microbial bile salt hydrolase to regulate blood lipids. Low denstiy lipoprotein (LDL) is easily converted into oxidized LDL, thereby promoting inflammation, while high denstiy lipoprotein (HDL) has the opposite effect. Probiotics compete with intestinal microorganisms for nutrients or ecological sites and thus affect the structure of intestinal microbiota. Moreover, microbial short chain fatty acids, bile salt hydrolase, superoxide dismutase, glutathione, etc. can affect lipid metabolism and IBD. In conclusion, probiotics are directly or indirectly involved in lipids metabolism and their impact on IBD, which provides the possibility to explore the role of probiotics in improving gut health.https://www.frontiersin.org/articles/10.3389/fnut.2022.917043/fullinflammatory bowel diseasebowel cancerlipid metabolismgut microbiotaprobiotics |
| spellingShingle | Taoying Wu Taoying Wu Guangqiang Wang Zhiqiang Xiong Yongjun Xia Xin Song Hui Zhang Yan Wu Lianzhong Ai Probiotics Interact With Lipids Metabolism and Affect Gut Health Frontiers in Nutrition inflammatory bowel disease bowel cancer lipid metabolism gut microbiota probiotics |
| title | Probiotics Interact With Lipids Metabolism and Affect Gut Health |
| title_full | Probiotics Interact With Lipids Metabolism and Affect Gut Health |
| title_fullStr | Probiotics Interact With Lipids Metabolism and Affect Gut Health |
| title_full_unstemmed | Probiotics Interact With Lipids Metabolism and Affect Gut Health |
| title_short | Probiotics Interact With Lipids Metabolism and Affect Gut Health |
| title_sort | probiotics interact with lipids metabolism and affect gut health |
| topic | inflammatory bowel disease bowel cancer lipid metabolism gut microbiota probiotics |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.917043/full |
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