Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study
Introduction: Retinal imaging is a non-invasive tool to study both retinal vasculature and neurodegeneration. In this exploratory retinal curcumin-fluorescence imaging (RFI) study, we sought to determine whether retinal vascular features combined with retinal amyloid burden correlate with the neuroc...
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MDPI AG
2021-10-01
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| Online Access: | https://www.mdpi.com/2073-4409/10/11/2926 |
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| author | Oana M. Dumitrascu Ryan Rosenberry Dale S. Sherman Maziyar M. Khansari Julia Sheyn Tania Torbati Ayesha Sherzai Dean Sherzai Kenneth O. Johnson Alan D. Czeszynski Steven Verdooner Keith L. Black Sally Frautschy Patrick D. Lyden Yonggang Shi Susan Cheng Yosef Koronyo Maya Koronyo-Hamaoui |
| author_facet | Oana M. Dumitrascu Ryan Rosenberry Dale S. Sherman Maziyar M. Khansari Julia Sheyn Tania Torbati Ayesha Sherzai Dean Sherzai Kenneth O. Johnson Alan D. Czeszynski Steven Verdooner Keith L. Black Sally Frautschy Patrick D. Lyden Yonggang Shi Susan Cheng Yosef Koronyo Maya Koronyo-Hamaoui |
| author_sort | Oana M. Dumitrascu |
| collection | DOAJ |
| description | Introduction: Retinal imaging is a non-invasive tool to study both retinal vasculature and neurodegeneration. In this exploratory retinal curcumin-fluorescence imaging (RFI) study, we sought to determine whether retinal vascular features combined with retinal amyloid burden correlate with the neurocognitive status. Methods: We used quantitative RFI in a cohort of patients with cognitive impairment to automatically compute retinal amyloid burden. Retinal blood vessels were segmented, and the vessel tortuosity index (VTI), inflection index, and branching angle were quantified. We assessed the correlations between retinal vascular and amyloid parameters, and cognitive domain Z-scores using linear regression models. Results: Thirty-four subjects were enrolled and twenty-nine (55% female, mean age 64 ± 6 years) were included in the combined retinal amyloid and vascular analysis. Eleven subjects had normal cognition and 18 had impaired cognition. Retinal VTI was discriminated among cognitive scores. The combined proximal mid-periphery amyloid count and venous VTI index exhibited significant differences between cognitively impaired and cognitively normal subjects (0.49 ± 1.1 vs. 0.91 ± 1.4, <i>p</i> = 0.006), and correlated with both the Wechsler Memory Scale-IV and SF-36 mental component score Z-scores (<i>p</i> < 0.05). Conclusion: This pilot study showed that retinal venular VTI combined with the proximal mid-periphery amyloid count could predict verbal memory loss. Future research is needed to finesse the clinical application of this retinal imaging-based technology. |
| first_indexed | 2024-03-10T05:37:32Z |
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| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:37:32Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-91af713ab8eb49d9acfd6ded438d58102023-11-22T22:48:48ZengMDPI AGCells2073-44092021-10-011011292610.3390/cells10112926Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot StudyOana M. Dumitrascu0Ryan Rosenberry1Dale S. Sherman2Maziyar M. Khansari3Julia Sheyn4Tania Torbati5Ayesha Sherzai6Dean Sherzai7Kenneth O. Johnson8Alan D. Czeszynski9Steven Verdooner10Keith L. Black11Sally Frautschy12Patrick D. Lyden13Yonggang Shi14Susan Cheng15Yosef Koronyo16Maya Koronyo-Hamaoui17Department of Neurology, Mayo Clinic, Scottsdale, AZ 85251, USADepartment of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Neuropsychology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAUSC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90007, USADepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Neurology, Loma Linda University, Loma Linda, CA 92350, USADepartment of Neurology, Loma Linda University, Loma Linda, CA 92350, USANeuroVision Imaging Inc., Sacramento, CA 95833, USANeuroVision Imaging Inc., Sacramento, CA 95833, USANeuroVision Imaging Inc., Sacramento, CA 95833, USADepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Neurology, University of California Los Angeles, Los Angeles, CA 90095, USADepartment of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAUSC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA 90007, USADepartment of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAIntroduction: Retinal imaging is a non-invasive tool to study both retinal vasculature and neurodegeneration. In this exploratory retinal curcumin-fluorescence imaging (RFI) study, we sought to determine whether retinal vascular features combined with retinal amyloid burden correlate with the neurocognitive status. Methods: We used quantitative RFI in a cohort of patients with cognitive impairment to automatically compute retinal amyloid burden. Retinal blood vessels were segmented, and the vessel tortuosity index (VTI), inflection index, and branching angle were quantified. We assessed the correlations between retinal vascular and amyloid parameters, and cognitive domain Z-scores using linear regression models. Results: Thirty-four subjects were enrolled and twenty-nine (55% female, mean age 64 ± 6 years) were included in the combined retinal amyloid and vascular analysis. Eleven subjects had normal cognition and 18 had impaired cognition. Retinal VTI was discriminated among cognitive scores. The combined proximal mid-periphery amyloid count and venous VTI index exhibited significant differences between cognitively impaired and cognitively normal subjects (0.49 ± 1.1 vs. 0.91 ± 1.4, <i>p</i> = 0.006), and correlated with both the Wechsler Memory Scale-IV and SF-36 mental component score Z-scores (<i>p</i> < 0.05). Conclusion: This pilot study showed that retinal venular VTI combined with the proximal mid-periphery amyloid count could predict verbal memory loss. Future research is needed to finesse the clinical application of this retinal imaging-based technology.https://www.mdpi.com/2073-4409/10/11/2926retinopathyretinal vesselsretinal fluorescence imagingamyloidcognitive declineAlzheimer’s disease |
| spellingShingle | Oana M. Dumitrascu Ryan Rosenberry Dale S. Sherman Maziyar M. Khansari Julia Sheyn Tania Torbati Ayesha Sherzai Dean Sherzai Kenneth O. Johnson Alan D. Czeszynski Steven Verdooner Keith L. Black Sally Frautschy Patrick D. Lyden Yonggang Shi Susan Cheng Yosef Koronyo Maya Koronyo-Hamaoui Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study Cells retinopathy retinal vessels retinal fluorescence imaging amyloid cognitive decline Alzheimer’s disease |
| title | Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study |
| title_full | Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study |
| title_fullStr | Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study |
| title_full_unstemmed | Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study |
| title_short | Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study |
| title_sort | retinal venular tortuosity jointly with retinal amyloid burden correlates with verbal memory loss a pilot study |
| topic | retinopathy retinal vessels retinal fluorescence imaging amyloid cognitive decline Alzheimer’s disease |
| url | https://www.mdpi.com/2073-4409/10/11/2926 |
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