Cardiac tissue engineering: current state-of-the-art materials, cells and tissue formation
ABSTRACT Cardiovascular diseases are the major cause of death worldwide. The heart has limited capacity of regeneration, therefore, transplantation is the only solution in some cases despite presenting many disadvantages. Tissue engineering has been considered the ideal strategy for regenerative med...
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| Format: | Article |
| Language: | English |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
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| Series: | Einstein (São Paulo) |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082018000300600&lng=en&tlng=en |
| _version_ | 1818600999613366272 |
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| author | Isabella Caroline Pereira Rodrigues Andreas Kaasi Rubens Maciel Filho André Luiz Jardini Laís Pellizzer Gabriel |
| author_facet | Isabella Caroline Pereira Rodrigues Andreas Kaasi Rubens Maciel Filho André Luiz Jardini Laís Pellizzer Gabriel |
| author_sort | Isabella Caroline Pereira Rodrigues |
| collection | DOAJ |
| description | ABSTRACT Cardiovascular diseases are the major cause of death worldwide. The heart has limited capacity of regeneration, therefore, transplantation is the only solution in some cases despite presenting many disadvantages. Tissue engineering has been considered the ideal strategy for regenerative medicine in cardiology. It is an interdisciplinary field combining many techniques that aim to maintain, regenerate or replace a tissue or organ. The main approach of cardiac tissue engineering is to create cardiac grafts, either whole heart substitutes or tissues that can be efficiently implanted in the organism, regenerating the tissue and giving rise to a fully functional heart, without causing side effects, such as immunogenicity. In this review, we systematically present and compare the techniques that have drawn the most attention in this field and that generally have focused on four important issues: the scaffold material selection, the scaffold material production, cellular selection and in vitro cell culture. Many studies used several techniques that are herein presented, including biopolymers, decellularization and bioreactors, and made significant advances, either seeking a graft or an entire bioartificial heart. However, much work remains to better understand and improve existing techniques, to develop robust, efficient and efficacious methods. |
| first_indexed | 2024-12-16T12:44:25Z |
| format | Article |
| id | doaj.art-91affa3d6b9c4f3cbef034b6cd74a9a2 |
| institution | Directory Open Access Journal |
| issn | 2317-6385 |
| language | English |
| last_indexed | 2024-12-16T12:44:25Z |
| publisher | Instituto Israelita de Ensino e Pesquisa Albert Einstein |
| record_format | Article |
| series | Einstein (São Paulo) |
| spelling | doaj.art-91affa3d6b9c4f3cbef034b6cd74a9a22022-12-21T22:31:19ZengInstituto Israelita de Ensino e Pesquisa Albert EinsteinEinstein (São Paulo)2317-638516310.1590/s1679-45082018rb4538S1679-45082018000300600Cardiac tissue engineering: current state-of-the-art materials, cells and tissue formationIsabella Caroline Pereira RodriguesAndreas KaasiRubens Maciel FilhoAndré Luiz JardiniLaís Pellizzer GabrielABSTRACT Cardiovascular diseases are the major cause of death worldwide. The heart has limited capacity of regeneration, therefore, transplantation is the only solution in some cases despite presenting many disadvantages. Tissue engineering has been considered the ideal strategy for regenerative medicine in cardiology. It is an interdisciplinary field combining many techniques that aim to maintain, regenerate or replace a tissue or organ. The main approach of cardiac tissue engineering is to create cardiac grafts, either whole heart substitutes or tissues that can be efficiently implanted in the organism, regenerating the tissue and giving rise to a fully functional heart, without causing side effects, such as immunogenicity. In this review, we systematically present and compare the techniques that have drawn the most attention in this field and that generally have focused on four important issues: the scaffold material selection, the scaffold material production, cellular selection and in vitro cell culture. Many studies used several techniques that are herein presented, including biopolymers, decellularization and bioreactors, and made significant advances, either seeking a graft or an entire bioartificial heart. However, much work remains to better understand and improve existing techniques, to develop robust, efficient and efficacious methods.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082018000300600&lng=en&tlng=enBiopolymersBioreactorsHeart transplantationCardiomyoplastyCardiovascular diseasesTissue engineering |
| spellingShingle | Isabella Caroline Pereira Rodrigues Andreas Kaasi Rubens Maciel Filho André Luiz Jardini Laís Pellizzer Gabriel Cardiac tissue engineering: current state-of-the-art materials, cells and tissue formation Einstein (São Paulo) Biopolymers Bioreactors Heart transplantation Cardiomyoplasty Cardiovascular diseases Tissue engineering |
| title | Cardiac tissue engineering: current state-of-the-art materials, cells and tissue formation |
| title_full | Cardiac tissue engineering: current state-of-the-art materials, cells and tissue formation |
| title_fullStr | Cardiac tissue engineering: current state-of-the-art materials, cells and tissue formation |
| title_full_unstemmed | Cardiac tissue engineering: current state-of-the-art materials, cells and tissue formation |
| title_short | Cardiac tissue engineering: current state-of-the-art materials, cells and tissue formation |
| title_sort | cardiac tissue engineering current state of the art materials cells and tissue formation |
| topic | Biopolymers Bioreactors Heart transplantation Cardiomyoplasty Cardiovascular diseases Tissue engineering |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082018000300600&lng=en&tlng=en |
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