Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases
Abstract Cardiovascular diseases (CVDs) continue to be a significant contributor to global mortality, imposing a substantial burden and emphasizing the urgent need for disease control to save lives and prevent disability. With advancements in technology and scientific research, novel mechanisms unde...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | iMeta |
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| Online Access: | https://doi.org/10.1002/imt2.124 |
| _version_ | 1797740187197898752 |
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| author | Jing Xu Yicheng Yang Xin Li Shusi Ding Lemin Zheng Changming Xiong Yuejin Yang |
| author_facet | Jing Xu Yicheng Yang Xin Li Shusi Ding Lemin Zheng Changming Xiong Yuejin Yang |
| author_sort | Jing Xu |
| collection | DOAJ |
| description | Abstract Cardiovascular diseases (CVDs) continue to be a significant contributor to global mortality, imposing a substantial burden and emphasizing the urgent need for disease control to save lives and prevent disability. With advancements in technology and scientific research, novel mechanisms underlying CVDs have been uncovered, leading to the exploration of promising treatment targets aimed at reducing the global burden of the disease. One of the most intriguing findings is the relationship between CVDs and gut microbiota, challenging the traditional understanding of CVDs mechanisms and introducing the concept of the gut‐heart axis. The gut microbiota, through changes in microbial compositions and functions, plays a crucial role in influencing local and systemic effects on host physiology and disease development, with its metabolites acting as key regulators. In previous studies, we have emphasized the importance of specific metabolites such as betaine, putrescine, trimethylamine oxide, and N,N,N‐trimethyl‐5‐aminovaleric acid in the potential treatment of CVDs. Particularly noteworthy is the gut microbiota‐associated metabolite succinate, which has garnered significant attention due to its involvement in various pathophysiological pathways closely related to CVDs pathogenesis, including immunoinflammatory responses, oxidative stress, and energy metabolism. Furthermore, we have identified succinate as a potential biomarker, highlighting its therapeutic feasibility in managing aortic dissection and aneurysm. This review aims to comprehensively outline the characteristics of succinate, including its biosynthetic process, summarize the current evidence linking it to CVDs causation, and emphasize the host‐microbial crosstalk involved in modulating CVDs. The insights presented here offer a novel paradigm for future management and control of CVDs. |
| first_indexed | 2024-03-12T14:08:51Z |
| format | Article |
| id | doaj.art-91b0bc2aaccc4bbfbebf40dd85e860f8 |
| institution | Directory Open Access Journal |
| issn | 2770-596X |
| language | English |
| last_indexed | 2024-03-12T14:08:51Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMeta |
| spelling | doaj.art-91b0bc2aaccc4bbfbebf40dd85e860f82023-08-21T10:57:32ZengWileyiMeta2770-596X2023-08-0123n/an/a10.1002/imt2.124Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseasesJing Xu0Yicheng Yang1Xin Li2Shusi Ding3Lemin Zheng4Changming Xiong5Yuejin Yang6Department of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaRespiratory and Pulmonary Vascular Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaRespiratory and Pulmonary Vascular Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaChina National Clinical Research Center for Neurological Diseases, Tiantan Hospital, Advanced Innovation Center for Human Brain Protection The Capital Medical University Beijing ChinaChina National Clinical Research Center for Neurological Diseases, Tiantan Hospital, Advanced Innovation Center for Human Brain Protection The Capital Medical University Beijing ChinaRespiratory and Pulmonary Vascular Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaDepartment of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaAbstract Cardiovascular diseases (CVDs) continue to be a significant contributor to global mortality, imposing a substantial burden and emphasizing the urgent need for disease control to save lives and prevent disability. With advancements in technology and scientific research, novel mechanisms underlying CVDs have been uncovered, leading to the exploration of promising treatment targets aimed at reducing the global burden of the disease. One of the most intriguing findings is the relationship between CVDs and gut microbiota, challenging the traditional understanding of CVDs mechanisms and introducing the concept of the gut‐heart axis. The gut microbiota, through changes in microbial compositions and functions, plays a crucial role in influencing local and systemic effects on host physiology and disease development, with its metabolites acting as key regulators. In previous studies, we have emphasized the importance of specific metabolites such as betaine, putrescine, trimethylamine oxide, and N,N,N‐trimethyl‐5‐aminovaleric acid in the potential treatment of CVDs. Particularly noteworthy is the gut microbiota‐associated metabolite succinate, which has garnered significant attention due to its involvement in various pathophysiological pathways closely related to CVDs pathogenesis, including immunoinflammatory responses, oxidative stress, and energy metabolism. Furthermore, we have identified succinate as a potential biomarker, highlighting its therapeutic feasibility in managing aortic dissection and aneurysm. This review aims to comprehensively outline the characteristics of succinate, including its biosynthetic process, summarize the current evidence linking it to CVDs causation, and emphasize the host‐microbial crosstalk involved in modulating CVDs. The insights presented here offer a novel paradigm for future management and control of CVDs.https://doi.org/10.1002/imt2.124biosynthetic pathwaycardiovascular diseasesgut microbiotamechanismssuccinate |
| spellingShingle | Jing Xu Yicheng Yang Xin Li Shusi Ding Lemin Zheng Changming Xiong Yuejin Yang Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases iMeta biosynthetic pathway cardiovascular diseases gut microbiota mechanisms succinate |
| title | Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases |
| title_full | Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases |
| title_fullStr | Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases |
| title_full_unstemmed | Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases |
| title_short | Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases |
| title_sort | pleiotropic activities of succinate the interplay between gut microbiota and cardiovascular diseases |
| topic | biosynthetic pathway cardiovascular diseases gut microbiota mechanisms succinate |
| url | https://doi.org/10.1002/imt2.124 |
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