Incidence and radiotherapy treatment patterns of complicated bone metastases
Background: Despite the encouraging results of the SCORAD trial, single fraction radiotherapy (SFRT) remains underused for patients with complicated bone metastases with rates as low as 18–39%. We aimed to evaluate the incidence and treatment patterns of these metastases in patients being referred t...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Journal of Bone Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212137423000520 |
| _version_ | 1797319497367945216 |
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| author | Cedric Peters Julie Vandewiele Yolande Lievens Marc van Eijkeren Valérie Fonteyne Tom Boterberg Pieter Deseyne Liv Veldeman Wilfried De Neve Chris Monten Sabine Braems Fréderic Duprez Katrien Vandecasteele Piet Ost |
| author_facet | Cedric Peters Julie Vandewiele Yolande Lievens Marc van Eijkeren Valérie Fonteyne Tom Boterberg Pieter Deseyne Liv Veldeman Wilfried De Neve Chris Monten Sabine Braems Fréderic Duprez Katrien Vandecasteele Piet Ost |
| author_sort | Cedric Peters |
| collection | DOAJ |
| description | Background: Despite the encouraging results of the SCORAD trial, single fraction radiotherapy (SFRT) remains underused for patients with complicated bone metastases with rates as low as 18–39%. We aimed to evaluate the incidence and treatment patterns of these metastases in patients being referred to a tertiary centre for palliative radiotherapy. Materials and methods: We performed a retrospective review of all bone metastases treated at our centre from January 2013 until December 2017. Lesions were classified as uncomplicated or complicated. Complicated was defined as associated with (impending) fracture, existing spinal cord or cauda equina compression. Our protocol suggests using SFRT for all patients with complicated bone metastases, except for those with symptomatic neuraxial compression and a life expectancy of ≥28 weeks. Results: Overall, 37 % of all bone metastases were classified as complicated. Most often as a result of an (impending) fracture (56 %) or spinal cord compression (44 %). In 93 % of cases, complicated lesions were located in the spine, most commonly originating from prostate, breast and lung cancer (60 %). Median survival of patients with complicated bone metastases was 4 months. The use of SFRT for complicated bone metastases increased from 51 % to 85 % over the study period, reaching 100 % for patients with the poorest prognosis. Conclusions: Approximately 37 % of bone metastases are classified as complicated with the majority related to (impending) fracture. Patients with complicated bone metastases have a median survival of 4 months and were mostly treated with SFRT. |
| first_indexed | 2024-03-08T04:07:44Z |
| format | Article |
| id | doaj.art-91b0e8129c6843c69f4d2b4b2defd491 |
| institution | Directory Open Access Journal |
| issn | 2212-1374 |
| language | English |
| last_indexed | 2024-03-08T04:07:44Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Bone Oncology |
| spelling | doaj.art-91b0e8129c6843c69f4d2b4b2defd4912024-02-09T04:48:07ZengElsevierJournal of Bone Oncology2212-13742024-02-0144100519Incidence and radiotherapy treatment patterns of complicated bone metastasesCedric Peters0Julie Vandewiele1Yolande Lievens2Marc van Eijkeren3Valérie Fonteyne4Tom Boterberg5Pieter Deseyne6Liv Veldeman7Wilfried De Neve8Chris Monten9Sabine Braems10Fréderic Duprez11Katrien Vandecasteele12Piet Ost13Corresponding author.; Department of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumDepartment of Radiation Oncology, Ghent University Hospital and Ghent University, Ghent, BelgiumBackground: Despite the encouraging results of the SCORAD trial, single fraction radiotherapy (SFRT) remains underused for patients with complicated bone metastases with rates as low as 18–39%. We aimed to evaluate the incidence and treatment patterns of these metastases in patients being referred to a tertiary centre for palliative radiotherapy. Materials and methods: We performed a retrospective review of all bone metastases treated at our centre from January 2013 until December 2017. Lesions were classified as uncomplicated or complicated. Complicated was defined as associated with (impending) fracture, existing spinal cord or cauda equina compression. Our protocol suggests using SFRT for all patients with complicated bone metastases, except for those with symptomatic neuraxial compression and a life expectancy of ≥28 weeks. Results: Overall, 37 % of all bone metastases were classified as complicated. Most often as a result of an (impending) fracture (56 %) or spinal cord compression (44 %). In 93 % of cases, complicated lesions were located in the spine, most commonly originating from prostate, breast and lung cancer (60 %). Median survival of patients with complicated bone metastases was 4 months. The use of SFRT for complicated bone metastases increased from 51 % to 85 % over the study period, reaching 100 % for patients with the poorest prognosis. Conclusions: Approximately 37 % of bone metastases are classified as complicated with the majority related to (impending) fracture. Patients with complicated bone metastases have a median survival of 4 months and were mostly treated with SFRT.http://www.sciencedirect.com/science/article/pii/S2212137423000520Bone metastasesPalliative medicineRadiotherapy |
| spellingShingle | Cedric Peters Julie Vandewiele Yolande Lievens Marc van Eijkeren Valérie Fonteyne Tom Boterberg Pieter Deseyne Liv Veldeman Wilfried De Neve Chris Monten Sabine Braems Fréderic Duprez Katrien Vandecasteele Piet Ost Incidence and radiotherapy treatment patterns of complicated bone metastases Journal of Bone Oncology Bone metastases Palliative medicine Radiotherapy |
| title | Incidence and radiotherapy treatment patterns of complicated bone metastases |
| title_full | Incidence and radiotherapy treatment patterns of complicated bone metastases |
| title_fullStr | Incidence and radiotherapy treatment patterns of complicated bone metastases |
| title_full_unstemmed | Incidence and radiotherapy treatment patterns of complicated bone metastases |
| title_short | Incidence and radiotherapy treatment patterns of complicated bone metastases |
| title_sort | incidence and radiotherapy treatment patterns of complicated bone metastases |
| topic | Bone metastases Palliative medicine Radiotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2212137423000520 |
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