Pro- and anti-tumour activities of CD146/MCAM in breast cancer result from its heterogeneous expression and association with epithelial to mesenchymal transition

Pro- and anti-tumour activities of CD146/MCAM in breast cancer result from its heterogeneous expression and association with epithelial to mesenchymal transition

CD146, also known as melanoma cell adhesion molecule (MCAM), is expressed in numerous cancers and has been implicated in the regulation of metastasis. We show that CD146 negatively regulates transendothelial migration (TEM) in breast cancer. This inhibitory activity is reflected by a reduction in MC...

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Bibliographic Details
Main Authors: Aarren J. Mannion, Adam F. Odell, Syed Murtuza Baker, Laura C. Matthews, Pamela F. Jones, Graham P. Cook
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CD146
MCAM
transendothelial migration (TEM)
epithelial mesenchymal transition (EMT)
breast cancer
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1129015/full

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