Incorporating Clinical Imaging into the Delivery of Microbeam Radiation Therapy
Synchrotron microbeam radiation therapy is a promising pre-clinical radiation treatment modality; however, it comes with many technical challenges. This study describes the image guidance protocol used for Australia’s first long-term pre-clinical MRT treatment of rats bearing 9L gliosarcoma tumours....
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/19/9101 |
| _version_ | 1797516796276768768 |
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| author | Jason Paino Micah Barnes Elette Engels Jeremy Davis Susanna Guatelli Michael de Veer Chris Hall Daniel Häusermann Moeava Tehei Stéphanie Corde Anatoly Rosenfeld Michael Lerch |
| author_facet | Jason Paino Micah Barnes Elette Engels Jeremy Davis Susanna Guatelli Michael de Veer Chris Hall Daniel Häusermann Moeava Tehei Stéphanie Corde Anatoly Rosenfeld Michael Lerch |
| author_sort | Jason Paino |
| collection | DOAJ |
| description | Synchrotron microbeam radiation therapy is a promising pre-clinical radiation treatment modality; however, it comes with many technical challenges. This study describes the image guidance protocol used for Australia’s first long-term pre-clinical MRT treatment of rats bearing 9L gliosarcoma tumours. The protocol utilises existing infrastructure available at the Australian Synchrotron and the adjoining Monash Biomedical Imaging facility. The protocol is designed and optimised to treat small animals utilising high-resolution clinical CT for patient specific tumour identification, coupled with conventional radiography, using the recently developed <span style="font-variant: small-caps;">SyncMRT</span> program for image guidance. Dosimetry performed in small animal phantoms shows patient dose is comparable to standard clinical doses, with a CT associated dose of less than <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>1.39</mn></mrow></semantics></math></inline-formula><inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="normal">c</mi></semantics></math></inline-formula>Gy and a planar radiograh dose of less than <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>0.03</mn></mrow></semantics></math></inline-formula><inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="normal">c</mi></semantics></math></inline-formula>Gy. Experimental validation of alignment accuracy with radiographic film demonstrates end to end accuracy of less than <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>±</mo><mn>0.34</mn></mrow></semantics></math></inline-formula><inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="normal">m</mi></semantics></math></inline-formula><inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="normal">m</mi></semantics></math></inline-formula> in anatomical phantoms. Histological analysis of tumour-bearing rats treated with microbeam radiation therapy verifies that tumours are targeted well within applied treatment margins. To date, this technique has been used to treat 35 tumour-bearing rats. |
| first_indexed | 2024-03-10T07:06:53Z |
| format | Article |
| id | doaj.art-91b19c9127764f19b4b4d2aa5678841f |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T07:06:53Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj.art-91b19c9127764f19b4b4d2aa5678841f2023-11-22T15:47:46ZengMDPI AGApplied Sciences2076-34172021-09-011119910110.3390/app11199101Incorporating Clinical Imaging into the Delivery of Microbeam Radiation TherapyJason Paino0Micah Barnes1Elette Engels2Jeremy Davis3Susanna Guatelli4Michael de Veer5Chris Hall6Daniel Häusermann7Moeava Tehei8Stéphanie Corde9Anatoly Rosenfeld10Michael Lerch11Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, AustraliaCentre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, AustraliaCentre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, AustraliaCentre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, AustraliaCentre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, AustraliaMonash Biomedical Imaging, Monash University, Melbourne, VIC 3168, AustraliaImaging and Medical Beamline, Australian Nuclear Science and Technology Organisation—Australian Synchrotron, Kulin Nation, Clayton, VIC 3168, AustraliaImaging and Medical Beamline, Australian Nuclear Science and Technology Organisation—Australian Synchrotron, Kulin Nation, Clayton, VIC 3168, AustraliaCentre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, AustraliaCentre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, AustraliaCentre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, AustraliaCentre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, AustraliaSynchrotron microbeam radiation therapy is a promising pre-clinical radiation treatment modality; however, it comes with many technical challenges. This study describes the image guidance protocol used for Australia’s first long-term pre-clinical MRT treatment of rats bearing 9L gliosarcoma tumours. The protocol utilises existing infrastructure available at the Australian Synchrotron and the adjoining Monash Biomedical Imaging facility. The protocol is designed and optimised to treat small animals utilising high-resolution clinical CT for patient specific tumour identification, coupled with conventional radiography, using the recently developed <span style="font-variant: small-caps;">SyncMRT</span> program for image guidance. Dosimetry performed in small animal phantoms shows patient dose is comparable to standard clinical doses, with a CT associated dose of less than <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>1.39</mn></mrow></semantics></math></inline-formula><inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="normal">c</mi></semantics></math></inline-formula>Gy and a planar radiograh dose of less than <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>0.03</mn></mrow></semantics></math></inline-formula><inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="normal">c</mi></semantics></math></inline-formula>Gy. Experimental validation of alignment accuracy with radiographic film demonstrates end to end accuracy of less than <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>±</mo><mn>0.34</mn></mrow></semantics></math></inline-formula><inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="normal">m</mi></semantics></math></inline-formula><inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mi mathvariant="normal">m</mi></semantics></math></inline-formula> in anatomical phantoms. Histological analysis of tumour-bearing rats treated with microbeam radiation therapy verifies that tumours are targeted well within applied treatment margins. To date, this technique has been used to treat 35 tumour-bearing rats.https://www.mdpi.com/2076-3417/11/19/9101image guidancemicrobeam radiation therapyradiotherapyprotocoldosimetryin vivo |
| spellingShingle | Jason Paino Micah Barnes Elette Engels Jeremy Davis Susanna Guatelli Michael de Veer Chris Hall Daniel Häusermann Moeava Tehei Stéphanie Corde Anatoly Rosenfeld Michael Lerch Incorporating Clinical Imaging into the Delivery of Microbeam Radiation Therapy Applied Sciences image guidance microbeam radiation therapy radiotherapy protocol dosimetry in vivo |
| title | Incorporating Clinical Imaging into the Delivery of Microbeam Radiation Therapy |
| title_full | Incorporating Clinical Imaging into the Delivery of Microbeam Radiation Therapy |
| title_fullStr | Incorporating Clinical Imaging into the Delivery of Microbeam Radiation Therapy |
| title_full_unstemmed | Incorporating Clinical Imaging into the Delivery of Microbeam Radiation Therapy |
| title_short | Incorporating Clinical Imaging into the Delivery of Microbeam Radiation Therapy |
| title_sort | incorporating clinical imaging into the delivery of microbeam radiation therapy |
| topic | image guidance microbeam radiation therapy radiotherapy protocol dosimetry in vivo |
| url | https://www.mdpi.com/2076-3417/11/19/9101 |
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