Is sham cTBS real cTBS? The effect on EEG dynamics
Increasing sensitivity of modern evaluation tools allows for the study of weaker electric stimulation effects on neural populations. In the current study we examined the effects of sham continuous theta burst (cTBS) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex (DLPFC)...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-01-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.01043/full |
| _version_ | 1818035919685419008 |
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| author | Alexander eOpitz Alexander eOpitz Alexander eOpitz Alexander eOpitz Wynn eLegon Wynn eLegon Jerel eMueller Aaron eBarbour Walter ePaulus William J Tyler William J Tyler |
| author_facet | Alexander eOpitz Alexander eOpitz Alexander eOpitz Alexander eOpitz Wynn eLegon Wynn eLegon Jerel eMueller Aaron eBarbour Walter ePaulus William J Tyler William J Tyler |
| author_sort | Alexander eOpitz |
| collection | DOAJ |
| description | Increasing sensitivity of modern evaluation tools allows for the study of weaker electric stimulation effects on neural populations. In the current study we examined the effects of sham continuous theta burst (cTBS) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex (DLPFC) upon somatosensory evoked potentials (SEP) and frontal-parietal phase coupling of alpha and beta bands. Sham TMS results in an induced electric field amplitude roughly 5% that of real TMS with a similar spatial extent in cortex. Both real and sham cTBS reduced the amplitude of the frontal P14-N30 SEP and increased local phase coupling in the alpha-beta frequency bands of left frontal cortex. In addition, both sham and real cTBS increased frontal-parietal phase coupling in the alpha-beta bands concomitant with an increase in amplitude of parietal P50-N70 complex. These data suggest that weak electric fields from sham cTBS can affect both local and downstream neuronal circuits, though in a different manner than high strength TMS. |
| first_indexed | 2024-12-10T07:02:42Z |
| format | Article |
| id | doaj.art-91b1e5cad16045b8ba253f1283b918c6 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-10T07:02:42Z |
| publishDate | 2015-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-91b1e5cad16045b8ba253f1283b918c62022-12-22T01:58:16ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612015-01-01810.3389/fnhum.2014.01043121797Is sham cTBS real cTBS? The effect on EEG dynamicsAlexander eOpitz0Alexander eOpitz1Alexander eOpitz2Alexander eOpitz3Wynn eLegon4Wynn eLegon5Jerel eMueller6Aaron eBarbour7Walter ePaulus8William J Tyler9William J Tyler10Virginia Tech Carilion Research InstituteGeorg-August-UniversityNathan Kline InstituteChild Mind InstituteVirginia Tech Carilion Research InstituteUnniversity of MinnesotaVirginia TechVirginia Tech Carilion Research InstituteGeorg-August-UniversityVirginia Tech Carilion Research InstituteVirginia TechIncreasing sensitivity of modern evaluation tools allows for the study of weaker electric stimulation effects on neural populations. In the current study we examined the effects of sham continuous theta burst (cTBS) transcranial magnetic stimulation to the left dorsolateral prefrontal cortex (DLPFC) upon somatosensory evoked potentials (SEP) and frontal-parietal phase coupling of alpha and beta bands. Sham TMS results in an induced electric field amplitude roughly 5% that of real TMS with a similar spatial extent in cortex. Both real and sham cTBS reduced the amplitude of the frontal P14-N30 SEP and increased local phase coupling in the alpha-beta frequency bands of left frontal cortex. In addition, both sham and real cTBS increased frontal-parietal phase coupling in the alpha-beta bands concomitant with an increase in amplitude of parietal P50-N70 complex. These data suggest that weak electric fields from sham cTBS can affect both local and downstream neuronal circuits, though in a different manner than high strength TMS.http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.01043/fullEvoked Potentials, SomatosensoryEEGDLPFCTMSelectric fieldsham TMS |
| spellingShingle | Alexander eOpitz Alexander eOpitz Alexander eOpitz Alexander eOpitz Wynn eLegon Wynn eLegon Jerel eMueller Aaron eBarbour Walter ePaulus William J Tyler William J Tyler Is sham cTBS real cTBS? The effect on EEG dynamics Frontiers in Human Neuroscience Evoked Potentials, Somatosensory EEG DLPFC TMS electric field sham TMS |
| title | Is sham cTBS real cTBS? The effect on EEG dynamics |
| title_full | Is sham cTBS real cTBS? The effect on EEG dynamics |
| title_fullStr | Is sham cTBS real cTBS? The effect on EEG dynamics |
| title_full_unstemmed | Is sham cTBS real cTBS? The effect on EEG dynamics |
| title_short | Is sham cTBS real cTBS? The effect on EEG dynamics |
| title_sort | is sham ctbs real ctbs the effect on eeg dynamics |
| topic | Evoked Potentials, Somatosensory EEG DLPFC TMS electric field sham TMS |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2014.01043/full |
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