Diagnostic Performance of ElastPQ Point Shear Wave Elastography for Hepatic Fibrosis in Hepatitis B and Hepatitis C Patients
Introduction: Chronic viral hepatitis is a condition of hepatotropic viral infection associated with chronic inflammation, hepatocyte injury and progressive fibrosis. Non-invasive assessment of liver fibrosis in chronic hepatitis B and C patients has been increasing and used instead of liver bio...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Pvt. Ltd.
2021-04-01
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| Series: | International Journal of Anatomy Radiology and Surgery |
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| Online Access: | http://www.ijars.net/articles/PDF/2631/47731_CE[Ra]_F(Sh)_PF1(AG_SHU)_PFA(SHU)_PB(AG_SHU)_PN(SHU).pdf |
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| author | Hagalahalli Nagarajegowda Prade Seetharam Mahesh Nagaraju K Rashmi Nagarajaiah Chandandur Pradeepkumar Chakenahalli Puttaraju Nanjaraj Shivadas P Prathibha Hanji Ravindra Moorthy Supraja |
| author_facet | Hagalahalli Nagarajegowda Prade Seetharam Mahesh Nagaraju K Rashmi Nagarajaiah Chandandur Pradeepkumar Chakenahalli Puttaraju Nanjaraj Shivadas P Prathibha Hanji Ravindra Moorthy Supraja |
| author_sort | Hagalahalli Nagarajegowda Prade |
| collection | DOAJ |
| description | Introduction: Chronic viral hepatitis is a condition of hepatotropic
viral infection associated with chronic inflammation, hepatocyte
injury and progressive fibrosis. Non-invasive assessment of
liver fibrosis in chronic hepatitis B and C patients has been
increasing and used instead of liver biopsy.
Aim: To assess the diagnostic performance of ElastPQ Point
Shear Wave Elastography (ElastPQ PSWE) with liver biopsy
as the gold standard and comparing these results with other
serum fibrosis markers namely Aspartate to Platelet Ratio Index
(APRI), Fibrosis-4 Score (FIB4).
Materials and Methods: A cross-sectional study was carried
out in which 73 patients underwent ElastPQ PSWE and
Histopathological Examination (HPE) with METAVIR Scoring
system staging. Serum fibrosis indices including APRI and
FIB4 values were calculated. The diagnostic performance of
ElastPQ PSWE, APRI and FIB4 was evaluated using Area Under
Receiver Operating Characteristic (AUROCAUROC) curve
analysis, correlations of ElastPQ PSWE, APRI and FIB4 ratio
index with histopathological findings (as the reference standard)
were determined using Spearman’s correlation coefficient.
Results: Study included 73 patients with chronic hepatitis B
and hepatitis C, of which 8 (10.96%) were no/early fibrosis (F0-
F1); 20 (27.40%) were significant fibrosis (F2); 22 (30.13%) were
severe fibrosis (F3), and 23 (31.51%) were cirrhosis (F4). There
was a significant positive correlation between different stages
of liver fibrosis by liver biopsy and liver stiffness detected by
ElastPQ PSWE (r=0.912, p <0.0001). ElastPQ PSWE exhibited
higher diagnostic accuracy than the APRI and FIB4 for the
diagnosis of F0-F1 AUROC 0.980, 0.730, 0.710, respectively;
F2 AUROC 0.840, 0.662, 0.669 respectively; F3 0.564, 0.528,
0.500 AUROC, respectively; and F4 0.967, 0.783, 0.751
AUROC, respectively. Using AUROC curve, the optimal cut-off
of ElastPQ PSWE for stages F0-F1 is ≤3.9 kilopascals (kPa); F2
is ≤7.2kPa; F3 is ≥7.2kPa and F4 is≥10kPa.
Conclusion: ElastPQ PSWE is a promising non-invasive
method used for the evaluation of liver fibrosis, with high
diagnostic performance, high Negative Predictive Value (NPV)
and good specificity in evaluation of hepatitis B and hepatitis
C patients. |
| first_indexed | 2024-12-22T12:09:33Z |
| format | Article |
| id | doaj.art-91b2a390812949e983863ff01d9fbe5b |
| institution | Directory Open Access Journal |
| issn | 2277-8543 2455-6874 |
| language | English |
| last_indexed | 2024-12-22T12:09:33Z |
| publishDate | 2021-04-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | International Journal of Anatomy Radiology and Surgery |
| spelling | doaj.art-91b2a390812949e983863ff01d9fbe5b2022-12-21T18:26:20ZengJCDR Research and Publications Pvt. Ltd.International Journal of Anatomy Radiology and Surgery2277-85432455-68742021-04-01102RO40RO4310.7860/IJARS/2021/47731:2631Diagnostic Performance of ElastPQ Point Shear Wave Elastography for Hepatic Fibrosis in Hepatitis B and Hepatitis C PatientsHagalahalli Nagarajegowda Prade0Seetharam Mahesh1Nagaraju K Rashmi2Nagarajaiah Chandandur Pradeepkumar3Chakenahalli Puttaraju Nanjaraj4Shivadas P Prathibha5Hanji Ravindra6Moorthy Supraja7Associate Professor, Department of Radiology, Mysore Medical College and Research Institute, Mysore, Karnataka, India.Senior Resident, Department of Radiology, Mysore Medical College and Research Institute, Mysore, Karnataka, India.Senior Resident, Department of Radiology, Mysore Medical College and Research Institute, Mysore, Karnataka, India.Assistant Professor, Department of Radiology, Mysore Medical College and Research Institute, Mysore, Karnataka, India.Professor, Department of Radiology, Mysore Medical College and Research Institute, Mysore, Karnataka, India.Senior Resident, Department of Radiology, Mysore Medical College and Research Institute, Mysore, Karnataka, India.Senior Resident, Department of Radiology, Mysore Medical College and Research Institute, Mysore, Karnataka, India.Senior Resident, Department of Radiology, Mysore Medical College and Research Institute, Mysore, Karnataka, India.Introduction: Chronic viral hepatitis is a condition of hepatotropic viral infection associated with chronic inflammation, hepatocyte injury and progressive fibrosis. Non-invasive assessment of liver fibrosis in chronic hepatitis B and C patients has been increasing and used instead of liver biopsy. Aim: To assess the diagnostic performance of ElastPQ Point Shear Wave Elastography (ElastPQ PSWE) with liver biopsy as the gold standard and comparing these results with other serum fibrosis markers namely Aspartate to Platelet Ratio Index (APRI), Fibrosis-4 Score (FIB4). Materials and Methods: A cross-sectional study was carried out in which 73 patients underwent ElastPQ PSWE and Histopathological Examination (HPE) with METAVIR Scoring system staging. Serum fibrosis indices including APRI and FIB4 values were calculated. The diagnostic performance of ElastPQ PSWE, APRI and FIB4 was evaluated using Area Under Receiver Operating Characteristic (AUROCAUROC) curve analysis, correlations of ElastPQ PSWE, APRI and FIB4 ratio index with histopathological findings (as the reference standard) were determined using Spearman’s correlation coefficient. Results: Study included 73 patients with chronic hepatitis B and hepatitis C, of which 8 (10.96%) were no/early fibrosis (F0- F1); 20 (27.40%) were significant fibrosis (F2); 22 (30.13%) were severe fibrosis (F3), and 23 (31.51%) were cirrhosis (F4). There was a significant positive correlation between different stages of liver fibrosis by liver biopsy and liver stiffness detected by ElastPQ PSWE (r=0.912, p <0.0001). ElastPQ PSWE exhibited higher diagnostic accuracy than the APRI and FIB4 for the diagnosis of F0-F1 AUROC 0.980, 0.730, 0.710, respectively; F2 AUROC 0.840, 0.662, 0.669 respectively; F3 0.564, 0.528, 0.500 AUROC, respectively; and F4 0.967, 0.783, 0.751 AUROC, respectively. Using AUROC curve, the optimal cut-off of ElastPQ PSWE for stages F0-F1 is ≤3.9 kilopascals (kPa); F2 is ≤7.2kPa; F3 is ≥7.2kPa and F4 is≥10kPa. Conclusion: ElastPQ PSWE is a promising non-invasive method used for the evaluation of liver fibrosis, with high diagnostic performance, high Negative Predictive Value (NPV) and good specificity in evaluation of hepatitis B and hepatitis C patients.http://www.ijars.net/articles/PDF/2631/47731_CE[Ra]_F(Sh)_PF1(AG_SHU)_PFA(SHU)_PB(AG_SHU)_PN(SHU).pdfchronic viral hepatitisliver fibrosisnon-invasive tissue stiffness assessment |
| spellingShingle | Hagalahalli Nagarajegowda Prade Seetharam Mahesh Nagaraju K Rashmi Nagarajaiah Chandandur Pradeepkumar Chakenahalli Puttaraju Nanjaraj Shivadas P Prathibha Hanji Ravindra Moorthy Supraja Diagnostic Performance of ElastPQ Point Shear Wave Elastography for Hepatic Fibrosis in Hepatitis B and Hepatitis C Patients International Journal of Anatomy Radiology and Surgery chronic viral hepatitis liver fibrosis non-invasive tissue stiffness assessment |
| title | Diagnostic Performance of ElastPQ Point Shear Wave Elastography for Hepatic Fibrosis in Hepatitis B and Hepatitis C Patients |
| title_full | Diagnostic Performance of ElastPQ Point Shear Wave Elastography for Hepatic Fibrosis in Hepatitis B and Hepatitis C Patients |
| title_fullStr | Diagnostic Performance of ElastPQ Point Shear Wave Elastography for Hepatic Fibrosis in Hepatitis B and Hepatitis C Patients |
| title_full_unstemmed | Diagnostic Performance of ElastPQ Point Shear Wave Elastography for Hepatic Fibrosis in Hepatitis B and Hepatitis C Patients |
| title_short | Diagnostic Performance of ElastPQ Point Shear Wave Elastography for Hepatic Fibrosis in Hepatitis B and Hepatitis C Patients |
| title_sort | diagnostic performance of elastpq point shear wave elastography for hepatic fibrosis in hepatitis b and hepatitis c patients |
| topic | chronic viral hepatitis liver fibrosis non-invasive tissue stiffness assessment |
| url | http://www.ijars.net/articles/PDF/2631/47731_CE[Ra]_F(Sh)_PF1(AG_SHU)_PFA(SHU)_PB(AG_SHU)_PN(SHU).pdf |
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