Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest
The generation of harmful reactive oxygen species (ROS), including hydrogen peroxide, in out-of-hospital cardiac arrest (OHCA) survivors causes systemic ischemia/reperfusion injury that may lead to multiple organ dysfunction and mortality. We hypothesized that the antioxidant enzyme catalase may att...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/17/3906 |
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| author | Anton Früh Andrea Bileck Besnik Muqaku Raphael Wurm Benjamin Neuditschko Henrike Arfsten Lukas Galli Lukas Kriechbaumer Pia Hubner Georg Goliasch Gottfried Heinz Michael Holzer Fritz Sterz Christopher Adlbrecht Christopher Gerner Klaus Distelmaier |
| author_facet | Anton Früh Andrea Bileck Besnik Muqaku Raphael Wurm Benjamin Neuditschko Henrike Arfsten Lukas Galli Lukas Kriechbaumer Pia Hubner Georg Goliasch Gottfried Heinz Michael Holzer Fritz Sterz Christopher Adlbrecht Christopher Gerner Klaus Distelmaier |
| author_sort | Anton Früh |
| collection | DOAJ |
| description | The generation of harmful reactive oxygen species (ROS), including hydrogen peroxide, in out-of-hospital cardiac arrest (OHCA) survivors causes systemic ischemia/reperfusion injury that may lead to multiple organ dysfunction and mortality. We hypothesized that the antioxidant enzyme catalase may attenuate these pathophysiological processes after cardiac arrest. Therefore, we aimed to analyze the predictive value of catalase levels for mortality in OHCA survivors. In a prospective, single-center study, catalase levels were determined in OHCA survivors 48 h after the return of spontaneous circulation. Thirty-day mortality was defined as the study end point. A total of 96 OHCA survivors were enrolled, of whom 26% (<i>n</i> = 25) died within the first 30 days after OHCA. The median plasma intensity levels (log<sub>2</sub>) of catalase were 8.25 (IQR 7.64–8.81). Plasma levels of catalase were found to be associated with mortality, with an adjusted HR of 2.13 (95% CI 1.07–4.23, <i>p</i> = 0.032). A Kaplan–Meier analysis showed a significant increase in 30-day mortality in patients with high catalase plasma levels compared to patients with low catalase levels (<i>p</i> = 0.012). High plasma levels of catalase are a strong and independent predictor for 30-day mortality in OHCA survivors. This indicates that ROS-dependent tissue damage is playing a crucial role in fatal outcomes of post-cardiac syndrome patients. |
| first_indexed | 2024-03-10T08:08:57Z |
| format | Article |
| id | doaj.art-91b7e16ad1ab499da4daf5361022a1dc |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T08:08:57Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-91b7e16ad1ab499da4daf5361022a1dc2023-11-22T10:49:22ZengMDPI AGJournal of Clinical Medicine2077-03832021-08-011017390610.3390/jcm10173906Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac ArrestAnton Früh0Andrea Bileck1Besnik Muqaku2Raphael Wurm3Benjamin Neuditschko4Henrike Arfsten5Lukas Galli6Lukas Kriechbaumer7Pia Hubner8Georg Goliasch9Gottfried Heinz10Michael Holzer11Fritz Sterz12Christopher Adlbrecht13Christopher Gerner14Klaus Distelmaier15Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, AustriaDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, AustriaDepartment of Neurology, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, AustriaDepartment of Internal Medicine II, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Internal Medicine II, Medical University of Vienna, 1090 Vienna, AustriaUniversity Clinic of Orthopedics, Paracelsus Medical University Salzburg, 5020 Salzburg, AustriaDepartment of Emergency Medicine, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Internal Medicine II, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Internal Medicine II, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Emergency Medicine, Medical University of Vienna, 1090 Vienna, AustriaDepartment of Emergency Medicine, Medical University of Vienna, 1090 Vienna, AustriaImed19-Privat, Private Clinical Research Center, 1190 Vienna, AustriaDepartment of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, AustriaDepartment of Internal Medicine II, Medical University of Vienna, 1090 Vienna, AustriaThe generation of harmful reactive oxygen species (ROS), including hydrogen peroxide, in out-of-hospital cardiac arrest (OHCA) survivors causes systemic ischemia/reperfusion injury that may lead to multiple organ dysfunction and mortality. We hypothesized that the antioxidant enzyme catalase may attenuate these pathophysiological processes after cardiac arrest. Therefore, we aimed to analyze the predictive value of catalase levels for mortality in OHCA survivors. In a prospective, single-center study, catalase levels were determined in OHCA survivors 48 h after the return of spontaneous circulation. Thirty-day mortality was defined as the study end point. A total of 96 OHCA survivors were enrolled, of whom 26% (<i>n</i> = 25) died within the first 30 days after OHCA. The median plasma intensity levels (log<sub>2</sub>) of catalase were 8.25 (IQR 7.64–8.81). Plasma levels of catalase were found to be associated with mortality, with an adjusted HR of 2.13 (95% CI 1.07–4.23, <i>p</i> = 0.032). A Kaplan–Meier analysis showed a significant increase in 30-day mortality in patients with high catalase plasma levels compared to patients with low catalase levels (<i>p</i> = 0.012). High plasma levels of catalase are a strong and independent predictor for 30-day mortality in OHCA survivors. This indicates that ROS-dependent tissue damage is playing a crucial role in fatal outcomes of post-cardiac syndrome patients.https://www.mdpi.com/2077-0383/10/17/3906catalaseMRMout-of-hospital cardiac arrestsurvivaltargeted proteomics |
| spellingShingle | Anton Früh Andrea Bileck Besnik Muqaku Raphael Wurm Benjamin Neuditschko Henrike Arfsten Lukas Galli Lukas Kriechbaumer Pia Hubner Georg Goliasch Gottfried Heinz Michael Holzer Fritz Sterz Christopher Adlbrecht Christopher Gerner Klaus Distelmaier Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest Journal of Clinical Medicine catalase MRM out-of-hospital cardiac arrest survival targeted proteomics |
| title | Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest |
| title_full | Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest |
| title_fullStr | Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest |
| title_full_unstemmed | Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest |
| title_short | Catalase Predicts In-Hospital Mortality after Out-of-Hospital Cardiac Arrest |
| title_sort | catalase predicts in hospital mortality after out of hospital cardiac arrest |
| topic | catalase MRM out-of-hospital cardiac arrest survival targeted proteomics |
| url | https://www.mdpi.com/2077-0383/10/17/3906 |
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