TrxR/Trx inhibitor butaselen ameliorates pulmonary fibrosis by suppressing NF-κB/TGF-β1/Smads signaling

TrxR/Trx inhibitor butaselen ameliorates pulmonary fibrosis by suppressing NF-κB/TGF-β1/Smads signaling

Pulmonary fibrosis is highly lethal with limited treatments. Butaselen (BS) is an inhibitor of thioredoxin reductase (TrxR)/thioredoxin (Trx) with anti-tumor activity. However, its impact on pulmonary fibrosis and the involved mechanisms remain unclear. Here, we demonstrate that BS is a potential dr...

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Bibliographic Details
Main Authors: Yifan Chen, Hanwei Yin, Jing Sun, Guozhou Zhang, Ying Zhang, Huihui Zeng
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Pulmonary fibrosis
Thioredoxin reductase
Thioredoxin
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)
Transforming growth factor-β1 (TGF-β1)
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016207

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