Sacubitril/Valsartan Improves Left Atrial and Ventricular Strain and Strain Rate in Patients with Heart Failure with Reduced Ejection Fraction
Background: Data on the impact of sacubitril/valsartan (SV) therapy on phasic left atrial (LA) and left ventricular (LV) strain in heart failure with reduced ejection fraction (HFrEF) are limited. The aim of this study was to evaluate changes in two-dimensional speckle tracking (2D-STE) parameters w...
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MDPI AG
2023-04-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/4/995 |
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| author | Pedro Garcia Brás António Valentim Gonçalves Luísa Moura Branco Rita Ilhão Moreira Tiago Pereira-da-Silva Ana Galrinho Ana Teresa Timóteo Pedro Rio Ana Leal Fernanda Gameiro Rui M. Soares Rui Cruz Ferreira |
| author_facet | Pedro Garcia Brás António Valentim Gonçalves Luísa Moura Branco Rita Ilhão Moreira Tiago Pereira-da-Silva Ana Galrinho Ana Teresa Timóteo Pedro Rio Ana Leal Fernanda Gameiro Rui M. Soares Rui Cruz Ferreira |
| author_sort | Pedro Garcia Brás |
| collection | DOAJ |
| description | Background: Data on the impact of sacubitril/valsartan (SV) therapy on phasic left atrial (LA) and left ventricular (LV) strain in heart failure with reduced ejection fraction (HFrEF) are limited. The aim of this study was to evaluate changes in two-dimensional speckle tracking (2D-STE) parameters with SV therapy in HFrEF patients. Methods: Prospective evaluation of HFrEF patients receiving optimized medical therapy. Two-dimensional speckle tracking (2D-STE) parameters were assessed at baseline and after 6 months of SV therapy. LA strain and strain rate (SR) in reservoir, conduit, and contraction phases were compared with LV longitudinal, radial, and circumferential strain and SR and stratified according to heart rhythm and HFrEF etiology. Results: A total of 35 patients completed the 6-month follow-up, with a mean age of 59 ± 11 years, 40% in atrial fibrillation, 43% with ischemic etiology, and LVEF of 29 ± 6%. There were significant improvements in LA reservoir, conduit, and contractile strain and SR following SV therapy, particularly among patients in sinus rhythm. There were significant improvements in longitudinal, radial, and circumferential LV function indices. Conclusion: SV therapy in HFrEF was associated with improved longitudinal, radial, and circumferential function, particularly among patients in sinus rhythm. These findings can provide insights into the mechanisms underlying the improvement of cardiac function and help assess subclinical responses to the treatment. |
| first_indexed | 2024-03-11T04:50:10Z |
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| id | doaj.art-91b9b07731cf41f1a845d736bc6bbb0a |
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| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T04:50:10Z |
| publishDate | 2023-04-01 |
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| series | Life |
| spelling | doaj.art-91b9b07731cf41f1a845d736bc6bbb0a2023-11-17T20:06:37ZengMDPI AGLife2075-17292023-04-0113499510.3390/life13040995Sacubitril/Valsartan Improves Left Atrial and Ventricular Strain and Strain Rate in Patients with Heart Failure with Reduced Ejection FractionPedro Garcia Brás0António Valentim Gonçalves1Luísa Moura Branco2Rita Ilhão Moreira3Tiago Pereira-da-Silva4Ana Galrinho5Ana Teresa Timóteo6Pedro Rio7Ana Leal8Fernanda Gameiro9Rui M. Soares10Rui Cruz Ferreira11Hospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-024 Lisbon, PortugalHospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-024 Lisbon, PortugalHospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-024 Lisbon, PortugalHospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-024 Lisbon, PortugalHospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-024 Lisbon, PortugalHospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-024 Lisbon, PortugalHospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-024 Lisbon, PortugalHospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-024 Lisbon, PortugalHospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-024 Lisbon, PortugalHospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-024 Lisbon, PortugalHospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-024 Lisbon, PortugalHospital de Santa Marta, Centro Hospitalar Universitário de Lisboa Central, 1169-024 Lisbon, PortugalBackground: Data on the impact of sacubitril/valsartan (SV) therapy on phasic left atrial (LA) and left ventricular (LV) strain in heart failure with reduced ejection fraction (HFrEF) are limited. The aim of this study was to evaluate changes in two-dimensional speckle tracking (2D-STE) parameters with SV therapy in HFrEF patients. Methods: Prospective evaluation of HFrEF patients receiving optimized medical therapy. Two-dimensional speckle tracking (2D-STE) parameters were assessed at baseline and after 6 months of SV therapy. LA strain and strain rate (SR) in reservoir, conduit, and contraction phases were compared with LV longitudinal, radial, and circumferential strain and SR and stratified according to heart rhythm and HFrEF etiology. Results: A total of 35 patients completed the 6-month follow-up, with a mean age of 59 ± 11 years, 40% in atrial fibrillation, 43% with ischemic etiology, and LVEF of 29 ± 6%. There were significant improvements in LA reservoir, conduit, and contractile strain and SR following SV therapy, particularly among patients in sinus rhythm. There were significant improvements in longitudinal, radial, and circumferential LV function indices. Conclusion: SV therapy in HFrEF was associated with improved longitudinal, radial, and circumferential function, particularly among patients in sinus rhythm. These findings can provide insights into the mechanisms underlying the improvement of cardiac function and help assess subclinical responses to the treatment.https://www.mdpi.com/2075-1729/13/4/995left atrial strainlongitudinal strainradial straincircumferential strainspeckle tracking echocardiographysacubitril/valsartan |
| spellingShingle | Pedro Garcia Brás António Valentim Gonçalves Luísa Moura Branco Rita Ilhão Moreira Tiago Pereira-da-Silva Ana Galrinho Ana Teresa Timóteo Pedro Rio Ana Leal Fernanda Gameiro Rui M. Soares Rui Cruz Ferreira Sacubitril/Valsartan Improves Left Atrial and Ventricular Strain and Strain Rate in Patients with Heart Failure with Reduced Ejection Fraction Life left atrial strain longitudinal strain radial strain circumferential strain speckle tracking echocardiography sacubitril/valsartan |
| title | Sacubitril/Valsartan Improves Left Atrial and Ventricular Strain and Strain Rate in Patients with Heart Failure with Reduced Ejection Fraction |
| title_full | Sacubitril/Valsartan Improves Left Atrial and Ventricular Strain and Strain Rate in Patients with Heart Failure with Reduced Ejection Fraction |
| title_fullStr | Sacubitril/Valsartan Improves Left Atrial and Ventricular Strain and Strain Rate in Patients with Heart Failure with Reduced Ejection Fraction |
| title_full_unstemmed | Sacubitril/Valsartan Improves Left Atrial and Ventricular Strain and Strain Rate in Patients with Heart Failure with Reduced Ejection Fraction |
| title_short | Sacubitril/Valsartan Improves Left Atrial and Ventricular Strain and Strain Rate in Patients with Heart Failure with Reduced Ejection Fraction |
| title_sort | sacubitril valsartan improves left atrial and ventricular strain and strain rate in patients with heart failure with reduced ejection fraction |
| topic | left atrial strain longitudinal strain radial strain circumferential strain speckle tracking echocardiography sacubitril/valsartan |
| url | https://www.mdpi.com/2075-1729/13/4/995 |
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