Coexistence of medullary thyroid carcinoma and recurrent non-functional pituitary adenoma: a case report
Abstract Background Medullary thyroid carcinoma and pituitary adenoma are neuroendocrine tumors and their coexistence has not been reported in the literature, previously. Medullary thyroid carcinoma is a neoplasm of the thyroid gland arising from parafollicular c-cells producing calcitonin, and pitu...
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| Format: | Article |
| Language: | English |
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BMC
2018-08-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s13256-018-1745-5 |
| _version_ | 1811323041714536448 |
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| author | Mohammad Bagherzadeh Arya Aminorroaya Jamshid Vafaeimanesh Mohammad Reza Mohajeri-Tehrani |
| author_facet | Mohammad Bagherzadeh Arya Aminorroaya Jamshid Vafaeimanesh Mohammad Reza Mohajeri-Tehrani |
| author_sort | Mohammad Bagherzadeh |
| collection | DOAJ |
| description | Abstract Background Medullary thyroid carcinoma and pituitary adenoma are neuroendocrine tumors and their coexistence has not been reported in the literature, previously. Medullary thyroid carcinoma is a neoplasm of the thyroid gland arising from parafollicular c-cells producing calcitonin, and pituitary adenoma is a benign hyperplasia of the cells of the pituitary gland. Coexistence of these neoplasms can be explained by being affected by simultaneous primary neoplasms or tumor-to-tumor metastasis phenomenon. Case presentation We present the case of a 60-year-old Persian man who presented to the clinic with a chief complaint of headache for the last 2 months. His past medical history was significant for non-functional pituitary macroadenoma and medullary thyroid carcinoma and he had received a total thyroidectomy and a transsphenoidal surgery several years ago. Diagnostic evaluations revealed that the pituitary adenoma has recurred. He was well and symptom-free after the second transsphenoidal surgery for resection of the adenoma. Noticeably, investigations were negative for any form of multiple endocrine neoplasia syndromes; however, we could not rule them out definitively. Conclusions To the best of our knowledge, it is the first case reported in the literature of a patient who has been affected by recurrent non-functional pituitary adenoma and medullary thyroid carcinoma, concomitantly. Although this association can be accidental, it emphasizes the fact that patients with a history of a neoplasm should be monitored regularly in order to diagnose and treat possible second primary cancers in a timely manner. Of note, this consideration is of great importance in patients whose first neoplasms have better prognosis and survival rates, which provide them more time to develop second primary cancers, for example, pituitary adenoma. |
| first_indexed | 2024-04-13T13:46:53Z |
| format | Article |
| id | doaj.art-91ba3f5d63ef46f88e8b766cb5079d1d |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-13T13:46:53Z |
| publishDate | 2018-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-91ba3f5d63ef46f88e8b766cb5079d1d2022-12-22T02:44:27ZengBMCJournal of Medical Case Reports1752-19472018-08-011211310.1186/s13256-018-1745-5Coexistence of medullary thyroid carcinoma and recurrent non-functional pituitary adenoma: a case reportMohammad Bagherzadeh0Arya Aminorroaya1Jamshid Vafaeimanesh2Mohammad Reza Mohajeri-Tehrani3Clinical Research Development Center, Qom University of Medical SciencesStudents’ Scientific Research Center (SSRC), Tehran University of Medical SciencesGastroenterology and Hepatology Research Center, Qom University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesAbstract Background Medullary thyroid carcinoma and pituitary adenoma are neuroendocrine tumors and their coexistence has not been reported in the literature, previously. Medullary thyroid carcinoma is a neoplasm of the thyroid gland arising from parafollicular c-cells producing calcitonin, and pituitary adenoma is a benign hyperplasia of the cells of the pituitary gland. Coexistence of these neoplasms can be explained by being affected by simultaneous primary neoplasms or tumor-to-tumor metastasis phenomenon. Case presentation We present the case of a 60-year-old Persian man who presented to the clinic with a chief complaint of headache for the last 2 months. His past medical history was significant for non-functional pituitary macroadenoma and medullary thyroid carcinoma and he had received a total thyroidectomy and a transsphenoidal surgery several years ago. Diagnostic evaluations revealed that the pituitary adenoma has recurred. He was well and symptom-free after the second transsphenoidal surgery for resection of the adenoma. Noticeably, investigations were negative for any form of multiple endocrine neoplasia syndromes; however, we could not rule them out definitively. Conclusions To the best of our knowledge, it is the first case reported in the literature of a patient who has been affected by recurrent non-functional pituitary adenoma and medullary thyroid carcinoma, concomitantly. Although this association can be accidental, it emphasizes the fact that patients with a history of a neoplasm should be monitored regularly in order to diagnose and treat possible second primary cancers in a timely manner. Of note, this consideration is of great importance in patients whose first neoplasms have better prognosis and survival rates, which provide them more time to develop second primary cancers, for example, pituitary adenoma.http://link.springer.com/article/10.1186/s13256-018-1745-5Pituitary adenomaPituitary neoplasmsMultiple endocrine neoplasiaThyroid cancerMedullaryThyroid neoplasms |
| spellingShingle | Mohammad Bagherzadeh Arya Aminorroaya Jamshid Vafaeimanesh Mohammad Reza Mohajeri-Tehrani Coexistence of medullary thyroid carcinoma and recurrent non-functional pituitary adenoma: a case report Journal of Medical Case Reports Pituitary adenoma Pituitary neoplasms Multiple endocrine neoplasia Thyroid cancer Medullary Thyroid neoplasms |
| title | Coexistence of medullary thyroid carcinoma and recurrent non-functional pituitary adenoma: a case report |
| title_full | Coexistence of medullary thyroid carcinoma and recurrent non-functional pituitary adenoma: a case report |
| title_fullStr | Coexistence of medullary thyroid carcinoma and recurrent non-functional pituitary adenoma: a case report |
| title_full_unstemmed | Coexistence of medullary thyroid carcinoma and recurrent non-functional pituitary adenoma: a case report |
| title_short | Coexistence of medullary thyroid carcinoma and recurrent non-functional pituitary adenoma: a case report |
| title_sort | coexistence of medullary thyroid carcinoma and recurrent non functional pituitary adenoma a case report |
| topic | Pituitary adenoma Pituitary neoplasms Multiple endocrine neoplasia Thyroid cancer Medullary Thyroid neoplasms |
| url | http://link.springer.com/article/10.1186/s13256-018-1745-5 |
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