Impact of Maternal Weight Gain on the Newborn Metabolome
Pre-pregnancy obesity and excessive gestational weight gain (GWG) appear to affect birth weight and the offspring’s risk of obesity and disease later in life. However, the identification of the mediators of this relationship, could be of clinical interest, taking into account the presence of other c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/4/561 |
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| author | Teresa Guixeres-Esteve Francisco Ponce-Zanón José Manuel Morales Empar Lurbe Julio Alvarez-Pitti Daniel Monleón |
| author_facet | Teresa Guixeres-Esteve Francisco Ponce-Zanón José Manuel Morales Empar Lurbe Julio Alvarez-Pitti Daniel Monleón |
| author_sort | Teresa Guixeres-Esteve |
| collection | DOAJ |
| description | Pre-pregnancy obesity and excessive gestational weight gain (GWG) appear to affect birth weight and the offspring’s risk of obesity and disease later in life. However, the identification of the mediators of this relationship, could be of clinical interest, taking into account the presence of other confounding factors, such as genetics and other shared influences. The aim of this study was to evaluate the metabolomic profiles of infants at birth (cord blood) and 6 and 12 months after birth to identify offspring metabolites associated with maternal GWG. Nuclear Magnetic Resonance (NMR) metabolic profiles were measured in 154 plasma samples from newborns (82 cord blood samples) and in 46 and 26 of these samples at 6 months and 12 months of age, respectively. The levels of relative abundance of 73 metabolomic parameters were determined in all the samples. We performed univariate and machine-learning analysis of the association between the metabolic levels and maternal weight gain adjusted for mother‘s age, Body Mass Index (BMI), diabetes, diet adherence and infant sex. Overall, our results showed differences, both at the univariate level and in the machine-learning models, between the offspring, according to the tertiles of maternal weight gain. Some of these differences were resolved at 6 and 12 months of age, whereas some others remained. Lactate and leucine were the metabolites with the strongest and longest association with maternal weight gain during pregnancy. Leucine, as well as other significant metabolites, have been associated in the past with metabolic wellness in both general and obese populations. Our results suggest that the metabolic changes associated to excessive GWG are present in children from early life. |
| first_indexed | 2024-03-11T04:45:48Z |
| format | Article |
| id | doaj.art-91baba7f7a834e058d131f0b30dda61d |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T04:45:48Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-91baba7f7a834e058d131f0b30dda61d2023-11-17T20:25:13ZengMDPI AGMetabolites2218-19892023-04-0113456110.3390/metabo13040561Impact of Maternal Weight Gain on the Newborn MetabolomeTeresa Guixeres-Esteve0Francisco Ponce-Zanón1José Manuel Morales2Empar Lurbe3Julio Alvarez-Pitti4Daniel Monleón5Pediatric Department, Consorcio Hospital General, University of Valencia, 46014 Valencia, SpainPediatric Department, Consorcio Hospital General, University of Valencia, 46014 Valencia, SpainINCLIVA Biomedical Research Institute, Hospital Clínico, University of Valencia, 46010 Valencia, SpainPediatric Department, Consorcio Hospital General, University of Valencia, 46014 Valencia, SpainPediatric Department, Consorcio Hospital General, University of Valencia, 46014 Valencia, SpainINCLIVA Biomedical Research Institute, Hospital Clínico, University of Valencia, 46010 Valencia, SpainPre-pregnancy obesity and excessive gestational weight gain (GWG) appear to affect birth weight and the offspring’s risk of obesity and disease later in life. However, the identification of the mediators of this relationship, could be of clinical interest, taking into account the presence of other confounding factors, such as genetics and other shared influences. The aim of this study was to evaluate the metabolomic profiles of infants at birth (cord blood) and 6 and 12 months after birth to identify offspring metabolites associated with maternal GWG. Nuclear Magnetic Resonance (NMR) metabolic profiles were measured in 154 plasma samples from newborns (82 cord blood samples) and in 46 and 26 of these samples at 6 months and 12 months of age, respectively. The levels of relative abundance of 73 metabolomic parameters were determined in all the samples. We performed univariate and machine-learning analysis of the association between the metabolic levels and maternal weight gain adjusted for mother‘s age, Body Mass Index (BMI), diabetes, diet adherence and infant sex. Overall, our results showed differences, both at the univariate level and in the machine-learning models, between the offspring, according to the tertiles of maternal weight gain. Some of these differences were resolved at 6 and 12 months of age, whereas some others remained. Lactate and leucine were the metabolites with the strongest and longest association with maternal weight gain during pregnancy. Leucine, as well as other significant metabolites, have been associated in the past with metabolic wellness in both general and obese populations. Our results suggest that the metabolic changes associated to excessive GWG are present in children from early life.https://www.mdpi.com/2218-1989/13/4/561metabolomicsgestational weight gainoffspringnewbornumbilical cord |
| spellingShingle | Teresa Guixeres-Esteve Francisco Ponce-Zanón José Manuel Morales Empar Lurbe Julio Alvarez-Pitti Daniel Monleón Impact of Maternal Weight Gain on the Newborn Metabolome Metabolites metabolomics gestational weight gain offspring newborn umbilical cord |
| title | Impact of Maternal Weight Gain on the Newborn Metabolome |
| title_full | Impact of Maternal Weight Gain on the Newborn Metabolome |
| title_fullStr | Impact of Maternal Weight Gain on the Newborn Metabolome |
| title_full_unstemmed | Impact of Maternal Weight Gain on the Newborn Metabolome |
| title_short | Impact of Maternal Weight Gain on the Newborn Metabolome |
| title_sort | impact of maternal weight gain on the newborn metabolome |
| topic | metabolomics gestational weight gain offspring newborn umbilical cord |
| url | https://www.mdpi.com/2218-1989/13/4/561 |
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