Oxatomide modifies membrane fluidity of polymorphonuclear leukocytes from children with allergic asthma
Background: Plasma membrane fluidity of polymorphonuclear leukocytes (PMN) was investigated in 10 allergic asthmatic children before and after oxato-mide treatment. Methods: Membrane fluidity was studied by measuring the steady state fluorescence anisotropy of 1-(4-trimethylammoniumphenyl)-6-phenyl-...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2001-01-01
|
| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893015313629 |
| _version_ | 1819207025770364928 |
|---|---|
| author | Ahmad Kantar Giancarlo Falcioni Rosamaria Fiorini |
| author_facet | Ahmad Kantar Giancarlo Falcioni Rosamaria Fiorini |
| author_sort | Ahmad Kantar |
| collection | DOAJ |
| description | Background: Plasma membrane fluidity of polymorphonuclear leukocytes (PMN) was investigated in 10 allergic asthmatic children before and after oxato-mide treatment.
Methods: Membrane fluidity was studied by measuring the steady state fluorescence anisotropy of 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) incorporated into polymorphonuclear leukocyte (PMN) plasma membranes.
Results: There was an increase in membrane fluidity at the surface of PMN from asthmatic children. Oxatomide treatment significantly decreased PMN membrane fluidity.
Conclusions: These data suggest that oxatomide may induce changes in the physicochemical properties of the PMN plasma membrane in asthmatic subjects. These changes may modify the functional activities of PMN. |
| first_indexed | 2024-12-23T05:16:56Z |
| format | Article |
| id | doaj.art-91bbaac332c5483597ca98b6cf4119bc |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-23T05:16:56Z |
| publishDate | 2001-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-91bbaac332c5483597ca98b6cf4119bc2022-12-21T17:58:49ZengElsevierAllergology International1323-89302001-01-0150319119510.1046/j.1440-1592.2001.00219.xOxatomide modifies membrane fluidity of polymorphonuclear leukocytes from children with allergic asthmaAhmad Kantar0Giancarlo Falcioni1Rosamaria Fiorini2Division of Pediatric Medicine, Policlinico San Pietro, Ponte San Pietro, Bergamo, CamerinoDepartment of Molecular, Cellular and Animal Biology, University of Camerino, CamerinoDepartment of Biochemistry, University of Ancona, Ancona, ItalyBackground: Plasma membrane fluidity of polymorphonuclear leukocytes (PMN) was investigated in 10 allergic asthmatic children before and after oxato-mide treatment. Methods: Membrane fluidity was studied by measuring the steady state fluorescence anisotropy of 1-(4-trimethylammoniumphenyl)-6-phenyl-1,3,5-hexatriene (TMA-DPH) incorporated into polymorphonuclear leukocyte (PMN) plasma membranes. Results: There was an increase in membrane fluidity at the surface of PMN from asthmatic children. Oxatomide treatment significantly decreased PMN membrane fluidity. Conclusions: These data suggest that oxatomide may induce changes in the physicochemical properties of the PMN plasma membrane in asthmatic subjects. These changes may modify the functional activities of PMN.http://www.sciencedirect.com/science/article/pii/S1323893015313629bronchial asthmaleukocytemembrane fluidityoxatomide |
| spellingShingle | Ahmad Kantar Giancarlo Falcioni Rosamaria Fiorini Oxatomide modifies membrane fluidity of polymorphonuclear leukocytes from children with allergic asthma Allergology International bronchial asthma leukocyte membrane fluidity oxatomide |
| title | Oxatomide modifies membrane fluidity of polymorphonuclear leukocytes from children with allergic asthma |
| title_full | Oxatomide modifies membrane fluidity of polymorphonuclear leukocytes from children with allergic asthma |
| title_fullStr | Oxatomide modifies membrane fluidity of polymorphonuclear leukocytes from children with allergic asthma |
| title_full_unstemmed | Oxatomide modifies membrane fluidity of polymorphonuclear leukocytes from children with allergic asthma |
| title_short | Oxatomide modifies membrane fluidity of polymorphonuclear leukocytes from children with allergic asthma |
| title_sort | oxatomide modifies membrane fluidity of polymorphonuclear leukocytes from children with allergic asthma |
| topic | bronchial asthma leukocyte membrane fluidity oxatomide |
| url | http://www.sciencedirect.com/science/article/pii/S1323893015313629 |
| work_keys_str_mv | AT ahmadkantar oxatomidemodifiesmembranefluidityofpolymorphonuclearleukocytesfromchildrenwithallergicasthma AT giancarlofalcioni oxatomidemodifiesmembranefluidityofpolymorphonuclearleukocytesfromchildrenwithallergicasthma AT rosamariafiorini oxatomidemodifiesmembranefluidityofpolymorphonuclearleukocytesfromchildrenwithallergicasthma |