FLAIRectomy: Resecting beyond the Contrast Margin for Glioblastoma
The standard of care for isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM) is maximal resection followed by chemotherapy and radiation. Studies investigating the resection of GBM have primarily focused on the contrast enhancing portion of the tumor on magnetic resonance imaging. Histopathol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/5/544 |
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| author | Alexander F. Haddad Jacob S. Young Ramin A. Morshed Mitchel S. Berger |
| author_facet | Alexander F. Haddad Jacob S. Young Ramin A. Morshed Mitchel S. Berger |
| author_sort | Alexander F. Haddad |
| collection | DOAJ |
| description | The standard of care for isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM) is maximal resection followed by chemotherapy and radiation. Studies investigating the resection of GBM have primarily focused on the contrast enhancing portion of the tumor on magnetic resonance imaging. Histopathological studies, however, have demonstrated tumor infiltration within peri-tumoral fluid-attenuated inversion recovery (FLAIR) abnormalities, which is often not resected. The histopathology of FLAIR and local recurrence patterns of GBM have prompted interest in the resection of peri-tumoral FLAIR, or FLAIRectomy. To this point, recent studies have suggested a significant survival benefit associated with safe peri-tumoral FLAIR resection. In this review, we discuss the evidence surrounding the composition of peri-tumoral FLAIR, outcomes associated with FLAIRectomy, future directions of the field, and potential implications for patients. |
| first_indexed | 2024-03-10T03:14:44Z |
| format | Article |
| id | doaj.art-91bf221c219c4800b1a438be1e9b8057 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T03:14:44Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-91bf221c219c4800b1a438be1e9b80572023-11-23T10:16:53ZengMDPI AGBrain Sciences2076-34252022-04-0112554410.3390/brainsci12050544FLAIRectomy: Resecting beyond the Contrast Margin for GlioblastomaAlexander F. Haddad0Jacob S. Young1Ramin A. Morshed2Mitchel S. Berger3Department of Neurological Surgery, University of California San Francisco, 505 Parnassus Ave, M-779, San Francisco, CA 94143, USADepartment of Neurological Surgery, University of California San Francisco, 505 Parnassus Ave, M-779, San Francisco, CA 94143, USADepartment of Neurological Surgery, University of California San Francisco, 505 Parnassus Ave, M-779, San Francisco, CA 94143, USADepartment of Neurological Surgery, University of California San Francisco, 505 Parnassus Ave, M-779, San Francisco, CA 94143, USAThe standard of care for isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM) is maximal resection followed by chemotherapy and radiation. Studies investigating the resection of GBM have primarily focused on the contrast enhancing portion of the tumor on magnetic resonance imaging. Histopathological studies, however, have demonstrated tumor infiltration within peri-tumoral fluid-attenuated inversion recovery (FLAIR) abnormalities, which is often not resected. The histopathology of FLAIR and local recurrence patterns of GBM have prompted interest in the resection of peri-tumoral FLAIR, or FLAIRectomy. To this point, recent studies have suggested a significant survival benefit associated with safe peri-tumoral FLAIR resection. In this review, we discuss the evidence surrounding the composition of peri-tumoral FLAIR, outcomes associated with FLAIRectomy, future directions of the field, and potential implications for patients.https://www.mdpi.com/2076-3425/12/5/544glioblastomaresectionextent of resectionflair |
| spellingShingle | Alexander F. Haddad Jacob S. Young Ramin A. Morshed Mitchel S. Berger FLAIRectomy: Resecting beyond the Contrast Margin for Glioblastoma Brain Sciences glioblastoma resection extent of resection flair |
| title | FLAIRectomy: Resecting beyond the Contrast Margin for Glioblastoma |
| title_full | FLAIRectomy: Resecting beyond the Contrast Margin for Glioblastoma |
| title_fullStr | FLAIRectomy: Resecting beyond the Contrast Margin for Glioblastoma |
| title_full_unstemmed | FLAIRectomy: Resecting beyond the Contrast Margin for Glioblastoma |
| title_short | FLAIRectomy: Resecting beyond the Contrast Margin for Glioblastoma |
| title_sort | flairectomy resecting beyond the contrast margin for glioblastoma |
| topic | glioblastoma resection extent of resection flair |
| url | https://www.mdpi.com/2076-3425/12/5/544 |
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