| Summary: | Hydrogen sulfide (H<sub>2</sub>S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological processes in the body. It can be endogenously produced through many enzymes analogous to the cysteine family, while the exogenous source may involve inorganic sulfide salts. H<sub>2</sub>S has recently been well investigated with regard to the onset of various carcinogenic diseases such as lung, breast, ovaries, colon cancer, and neurodegenerative disorders. H<sub>2</sub>S is considered an oncogenic gas, and a potential therapeutic target for treating and diagnosing cancers, due to its role in mediating the development of tumorigenesis. Here in this review, an in-detail up-to-date explanation of the potential role of H<sub>2</sub>S in different malignancies has been reported. The study summarizes the synthesis of H<sub>2</sub>S, its roles, signaling routes, expressions, and H<sub>2</sub>S release in various malignancies. Considering the critical importance of this active biological molecule, we believe this review in this esteemed journal will highlight the oncogenic role of H<sub>2</sub>S in the scientific community.
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