Prevalence, Intensity, and Correlates of Soil-Transmitted Helminth Infections among School Children after a Decade of Preventive Chemotherapy in Western Rwanda
Preventive chemotherapy (PC) is a WHO-recommended core intervention measures to eliminate Soil-Transmitted Helminths (STH) as a public health problem by 2020, defined as a reduction in prevalence to <1% of moderate or high-intensity infection. We conducted a cross-sectional study to investigate t...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/9/12/1076 |
| _version_ | 1827699564716490752 |
|---|---|
| author | Joseph Kabatende Michael Mugisha Lazare Ntirenganya Abbie Barry Eugene Ruberanziza Jean Bosco Mbonigaba Ulf Bergman Emile Bienvenu Eleni Aklillu |
| author_facet | Joseph Kabatende Michael Mugisha Lazare Ntirenganya Abbie Barry Eugene Ruberanziza Jean Bosco Mbonigaba Ulf Bergman Emile Bienvenu Eleni Aklillu |
| author_sort | Joseph Kabatende |
| collection | DOAJ |
| description | Preventive chemotherapy (PC) is a WHO-recommended core intervention measures to eliminate Soil-Transmitted Helminths (STH) as a public health problem by 2020, defined as a reduction in prevalence to <1% of moderate or high-intensity infection. We conducted a cross-sectional study to investigate the prevalence, intensity, and correlates of STH after a decade of PC in Rwanda. A total of 4998 school children (5–15 years old) from four districts along Lake Kivu in the western province were screened for STH using Kato-Katz. The overall prevalence of Soil-transmitted helminths among school children was 77.7% (range between districts = 54% to 92%). <i>Trichirus trichiura</i> was the most common STH (66.8%, range between districts = 23% to 88.2%), followed by <i>Ascaris lumbricoides</i> (49.9%, range between district = 28.5% to 63.3%) and hookworms (1.9%, range between districts = 0.6% to 2.9%). The prevalence of single, double and of triple parasite coinfection were 48.6%, 50.3%, and 1.1%, respectively. The overall prevalence of moderate or high-intensity infection for <i>Trichirus trichiura</i> and <i>Ascaris lumbricoides</i> was 7.1% and 13.9, respectively. Multivariate logistic regression model revealed that male sex, district, stunting, and schistosomiasis coinfection as significant predictors of STH infection. Despite a decade of PC implementation, STH remain a significant public health problem in Rwanda. |
| first_indexed | 2024-03-10T13:52:25Z |
| format | Article |
| id | doaj.art-91c3fe11b23941f0a437893acb317f63 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T13:52:25Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-91c3fe11b23941f0a437893acb317f632023-11-21T01:58:10ZengMDPI AGPathogens2076-08172020-12-01912107610.3390/pathogens9121076Prevalence, Intensity, and Correlates of Soil-Transmitted Helminth Infections among School Children after a Decade of Preventive Chemotherapy in Western RwandaJoseph Kabatende0Michael Mugisha1Lazare Ntirenganya2Abbie Barry3Eugene Ruberanziza4Jean Bosco Mbonigaba5Ulf Bergman6Emile Bienvenu7Eleni Aklillu8Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge,14186 Stockholm, SwedenCollege of Medicine and Health Sciences, University of Rwanda, KK 737 Kigali, RwandaRwanda Food and Drugs Authority, Nyarutarama Plaza, KG 9 Avenue Kigali, RwandaDepartment of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge,14186 Stockholm, SwedenNeglected Tropical Disease and Other Parasitic Disease Unit, Rwanda Biomedical Center, KG 17 Ave Kigali, RwandaNeglected Tropical Disease and Other Parasitic Disease Unit, Rwanda Biomedical Center, KG 17 Ave Kigali, RwandaDepartment of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge,14186 Stockholm, SwedenCollege of Medicine and Health Sciences, University of Rwanda, KK 737 Kigali, RwandaDepartment of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital Huddinge,14186 Stockholm, SwedenPreventive chemotherapy (PC) is a WHO-recommended core intervention measures to eliminate Soil-Transmitted Helminths (STH) as a public health problem by 2020, defined as a reduction in prevalence to <1% of moderate or high-intensity infection. We conducted a cross-sectional study to investigate the prevalence, intensity, and correlates of STH after a decade of PC in Rwanda. A total of 4998 school children (5–15 years old) from four districts along Lake Kivu in the western province were screened for STH using Kato-Katz. The overall prevalence of Soil-transmitted helminths among school children was 77.7% (range between districts = 54% to 92%). <i>Trichirus trichiura</i> was the most common STH (66.8%, range between districts = 23% to 88.2%), followed by <i>Ascaris lumbricoides</i> (49.9%, range between district = 28.5% to 63.3%) and hookworms (1.9%, range between districts = 0.6% to 2.9%). The prevalence of single, double and of triple parasite coinfection were 48.6%, 50.3%, and 1.1%, respectively. The overall prevalence of moderate or high-intensity infection for <i>Trichirus trichiura</i> and <i>Ascaris lumbricoides</i> was 7.1% and 13.9, respectively. Multivariate logistic regression model revealed that male sex, district, stunting, and schistosomiasis coinfection as significant predictors of STH infection. Despite a decade of PC implementation, STH remain a significant public health problem in Rwanda.https://www.mdpi.com/2076-0817/9/12/1076mass drug administrationpreventive chemotherapyneglected tropical diseasesintestinal soil-transmitted helminthsprevalenceschool children |
| spellingShingle | Joseph Kabatende Michael Mugisha Lazare Ntirenganya Abbie Barry Eugene Ruberanziza Jean Bosco Mbonigaba Ulf Bergman Emile Bienvenu Eleni Aklillu Prevalence, Intensity, and Correlates of Soil-Transmitted Helminth Infections among School Children after a Decade of Preventive Chemotherapy in Western Rwanda Pathogens mass drug administration preventive chemotherapy neglected tropical diseases intestinal soil-transmitted helminths prevalence school children |
| title | Prevalence, Intensity, and Correlates of Soil-Transmitted Helminth Infections among School Children after a Decade of Preventive Chemotherapy in Western Rwanda |
| title_full | Prevalence, Intensity, and Correlates of Soil-Transmitted Helminth Infections among School Children after a Decade of Preventive Chemotherapy in Western Rwanda |
| title_fullStr | Prevalence, Intensity, and Correlates of Soil-Transmitted Helminth Infections among School Children after a Decade of Preventive Chemotherapy in Western Rwanda |
| title_full_unstemmed | Prevalence, Intensity, and Correlates of Soil-Transmitted Helminth Infections among School Children after a Decade of Preventive Chemotherapy in Western Rwanda |
| title_short | Prevalence, Intensity, and Correlates of Soil-Transmitted Helminth Infections among School Children after a Decade of Preventive Chemotherapy in Western Rwanda |
| title_sort | prevalence intensity and correlates of soil transmitted helminth infections among school children after a decade of preventive chemotherapy in western rwanda |
| topic | mass drug administration preventive chemotherapy neglected tropical diseases intestinal soil-transmitted helminths prevalence school children |
| url | https://www.mdpi.com/2076-0817/9/12/1076 |
| work_keys_str_mv | AT josephkabatende prevalenceintensityandcorrelatesofsoiltransmittedhelminthinfectionsamongschoolchildrenafteradecadeofpreventivechemotherapyinwesternrwanda AT michaelmugisha prevalenceintensityandcorrelatesofsoiltransmittedhelminthinfectionsamongschoolchildrenafteradecadeofpreventivechemotherapyinwesternrwanda AT lazarentirenganya prevalenceintensityandcorrelatesofsoiltransmittedhelminthinfectionsamongschoolchildrenafteradecadeofpreventivechemotherapyinwesternrwanda AT abbiebarry prevalenceintensityandcorrelatesofsoiltransmittedhelminthinfectionsamongschoolchildrenafteradecadeofpreventivechemotherapyinwesternrwanda AT eugeneruberanziza prevalenceintensityandcorrelatesofsoiltransmittedhelminthinfectionsamongschoolchildrenafteradecadeofpreventivechemotherapyinwesternrwanda AT jeanboscombonigaba prevalenceintensityandcorrelatesofsoiltransmittedhelminthinfectionsamongschoolchildrenafteradecadeofpreventivechemotherapyinwesternrwanda AT ulfbergman prevalenceintensityandcorrelatesofsoiltransmittedhelminthinfectionsamongschoolchildrenafteradecadeofpreventivechemotherapyinwesternrwanda AT emilebienvenu prevalenceintensityandcorrelatesofsoiltransmittedhelminthinfectionsamongschoolchildrenafteradecadeofpreventivechemotherapyinwesternrwanda AT eleniaklillu prevalenceintensityandcorrelatesofsoiltransmittedhelminthinfectionsamongschoolchildrenafteradecadeofpreventivechemotherapyinwesternrwanda |