Structural analysis of TRG1@ and TRG2@ loci of the ovine immune system
The cellular immune system visualizes the world of pathogens largely through its T cell immune receptors (TCRs), a dimer which may be αβ or γδ. The proportion of T cell expressing the γδ TCR, among total T lymphocytes, is known to vary great...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2011-03-01
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| Series: | Italian Journal of Animal Science |
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| Online Access: | http://www.aspajournal.it/index.php/ijas/article/view/1946 |
| _version_ | 1811281297252810752 |
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| author | S. Ciccarese A. Caputi Jambrenghi E.P. Cribiu M. Giovinazzo M.C. Miccoli G. Vaccarelli |
| author_facet | S. Ciccarese A. Caputi Jambrenghi E.P. Cribiu M. Giovinazzo M.C. Miccoli G. Vaccarelli |
| author_sort | S. Ciccarese |
| collection | DOAJ |
| description | The cellular immune system visualizes the world of pathogens largely through its T cell immune receptors (TCRs), a dimer which may be αβ or γδ. The proportion of T cell expressing the γδ TCR, among total T lymphocytes, is known to vary greatly between species. In human and mouse, γδ T cells account for less than 3% of the peripheral T cell pool (“γδ low” species), whereas in artiodactyls (Binns, 1992; Hein and MacKay, 1991) and chicken (Cooper, 1991), γδ T cell account for close to half of the peripheral T-cell pool (“γδ high” species). T cell receptor monomers are encoded by four distinct gene families: α, β, γ and δ contained within three chromosomal loci: α/δ, β and γ. The genes encoding the receptor chains are generated, during T cell development, by somatic rearrangement, of Variable (V), Diversity (D; in the β and δ loci only) and Joining (J) segments. After transcription, the V(D)J sequence is spliced to a Constant region, C. The genomic organization and chromosomal localization of TRG@ locus has been first determined in human (IMGT Database, 2002)......... |
| first_indexed | 2024-04-13T01:31:05Z |
| format | Article |
| id | doaj.art-91c407ff048448cfa0ee478e312863b6 |
| institution | Directory Open Access Journal |
| issn | 1594-4077 1828-051X |
| language | English |
| last_indexed | 2024-04-13T01:31:05Z |
| publishDate | 2011-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Italian Journal of Animal Science |
| spelling | doaj.art-91c407ff048448cfa0ee478e312863b62022-12-22T03:08:31ZengTaylor & Francis GroupItalian Journal of Animal Science1594-40771828-051X2011-03-0121S495110.4081/ijas.2003.s1.49Structural analysis of TRG1@ and TRG2@ loci of the ovine immune systemS. CiccareseA. Caputi JambrenghiE.P. CribiuM. GiovinazzoM.C. MiccoliG. VaccarelliThe cellular immune system visualizes the world of pathogens largely through its T cell immune receptors (TCRs), a dimer which may be αβ or γδ. The proportion of T cell expressing the γδ TCR, among total T lymphocytes, is known to vary greatly between species. In human and mouse, γδ T cells account for less than 3% of the peripheral T cell pool (“γδ low” species), whereas in artiodactyls (Binns, 1992; Hein and MacKay, 1991) and chicken (Cooper, 1991), γδ T cell account for close to half of the peripheral T-cell pool (“γδ high” species). T cell receptor monomers are encoded by four distinct gene families: α, β, γ and δ contained within three chromosomal loci: α/δ, β and γ. The genes encoding the receptor chains are generated, during T cell development, by somatic rearrangement, of Variable (V), Diversity (D; in the β and δ loci only) and Joining (J) segments. After transcription, the V(D)J sequence is spliced to a Constant region, C. The genomic organization and chromosomal localization of TRG@ locus has been first determined in human (IMGT Database, 2002).........http://www.aspajournal.it/index.php/ijas/article/view/1946T cell receptor, TRG@ loci, locus structural genomic organization. |
| spellingShingle | S. Ciccarese A. Caputi Jambrenghi E.P. Cribiu M. Giovinazzo M.C. Miccoli G. Vaccarelli Structural analysis of TRG1@ and TRG2@ loci of the ovine immune system Italian Journal of Animal Science T cell receptor, TRG@ loci, locus structural genomic organization. |
| title | Structural analysis of TRG1@ and TRG2@ loci of the ovine immune system |
| title_full | Structural analysis of TRG1@ and TRG2@ loci of the ovine immune system |
| title_fullStr | Structural analysis of TRG1@ and TRG2@ loci of the ovine immune system |
| title_full_unstemmed | Structural analysis of TRG1@ and TRG2@ loci of the ovine immune system |
| title_short | Structural analysis of TRG1@ and TRG2@ loci of the ovine immune system |
| title_sort | structural analysis of trg1 and trg2 loci of the ovine immune system |
| topic | T cell receptor, TRG@ loci, locus structural genomic organization. |
| url | http://www.aspajournal.it/index.php/ijas/article/view/1946 |
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