Abnormal directed connectivity of resting state networks in focal epilepsy
Objective: Epilepsy diagnosis can be difficult in the absence of interictal epileptic discharges (IED) on scalp EEG. We used high-density EEG to measure connectivity in large‐scale functional networks of patients with focal epilepsy (Temporal and Extratemporal Lobe Epilepsy, TLE and ETLE) and tested...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221315822030173X |
| _version_ | 1818262196519436288 |
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| author | Margherita Carboni Pia De Stefano Bernd J. Vorderwülbecke Sebastien Tourbier Emeline Mullier Maria Rubega Shahan Momjian Karl Schaller Patric Hagmann Margitta Seeck Christoph M. Michel Pieter van Mierlo Serge Vulliemoz |
| author_facet | Margherita Carboni Pia De Stefano Bernd J. Vorderwülbecke Sebastien Tourbier Emeline Mullier Maria Rubega Shahan Momjian Karl Schaller Patric Hagmann Margitta Seeck Christoph M. Michel Pieter van Mierlo Serge Vulliemoz |
| author_sort | Margherita Carboni |
| collection | DOAJ |
| description | Objective: Epilepsy diagnosis can be difficult in the absence of interictal epileptic discharges (IED) on scalp EEG. We used high-density EEG to measure connectivity in large‐scale functional networks of patients with focal epilepsy (Temporal and Extratemporal Lobe Epilepsy, TLE and ETLE) and tested for network alterations during resting wakefulness without IEDs, compared to healthy controls. We measured global efficiency as a marker of integration within networks. Methods: We analysed 49 adult patients with focal epilepsy and 16 healthy subjects who underwent high-density-EEG and structural MRI. We estimated cortical activity using electric source analysis in 82 atlas-based cortical regions based on the individual MRI. We applied directed connectivity analysis (Partial Directed Coherence) on these sources and performed graph analysis: we computed the Global Efficiency on the whole brain and on each resting state network. We tested these features in different group of patients. Results: Compared to controls, efficiency was increased in both TLE and ETLE (p < 0.05). The somato-motor-network, the ventral-attention-network and the default-mode-network had a significantly increased efficiency (p < 0.05) in both TLE and ETLE as well as TLE with hippocampal sclerosis. Significance: During interictal scalp EEG epochs without IED, patients with focal epilepsy show brain functional connectivity alterations in the whole brain and in specific resting-state-networks. This higher integration reflects a chronic effect of pathological activity within these structures and complement previous work on altered information outflow. These findings could increase the diagnostic sensitivity of scalp EEG to identify epileptic activity in the absence of IED. |
| first_indexed | 2024-12-12T18:59:17Z |
| format | Article |
| id | doaj.art-91c50a8bc03e45f598648a560defae59 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-12T18:59:17Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-91c50a8bc03e45f598648a560defae592022-12-22T00:15:08ZengElsevierNeuroImage: Clinical2213-15822020-01-0127102336Abnormal directed connectivity of resting state networks in focal epilepsyMargherita Carboni0Pia De Stefano1Bernd J. Vorderwülbecke2Sebastien Tourbier3Emeline Mullier4Maria Rubega5Shahan Momjian6Karl Schaller7Patric Hagmann8Margitta Seeck9Christoph M. Michel10Pieter van Mierlo11Serge Vulliemoz12EEG and Epilepsy Unit, Clinical Neuroscience Department, University Hospital and Faculty of Medicine of Geneva, Geneva, Switzerland; Functional Brain Mapping Lab, Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland; Corresponding author at: EEG and Epilepsy Unit, Clinical Neuroscience Department, University Hospital and Faculty of Medicine of Geneva, Geneva, Switzerland.EEG and Epilepsy Unit, Clinical Neuroscience Department, University Hospital and Faculty of Medicine of Geneva, Geneva, SwitzerlandEEG and Epilepsy Unit, Clinical Neuroscience Department, University Hospital and Faculty of Medicine of Geneva, Geneva, Switzerland; Epilepsy-Center Berlin-Brandenburg, Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin, GermanyConnectomics Lab, Department of Radiology, University Hospital of Lausanne, Lausanne, SwitzerlandConnectomics Lab, Department of Radiology, University Hospital of Lausanne, Lausanne, SwitzerlandFunctional Brain Mapping Lab, Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland; Department of Neurosciences, University of Padova, Padova, ItalyDepartment of Neurosurgery, University Hospital and Faculty of Medicine of Geneva, Geneva, SwitzerlandDepartment of Neurosurgery, University Hospital and Faculty of Medicine of Geneva, Geneva, SwitzerlandConnectomics Lab, Department of Radiology, University Hospital of Lausanne, Lausanne, SwitzerlandEEG and Epilepsy Unit, Clinical Neuroscience Department, University Hospital and Faculty of Medicine of Geneva, Geneva, SwitzerlandFunctional Brain Mapping Lab, Department of Fundamental Neurosciences, University of Geneva, Geneva, SwitzerlandMedical Image and Signal Processing Group, Department of Electronics and Information Systems, Ghent University, Ghent, BelgiumEEG and Epilepsy Unit, Clinical Neuroscience Department, University Hospital and Faculty of Medicine of Geneva, Geneva, SwitzerlandObjective: Epilepsy diagnosis can be difficult in the absence of interictal epileptic discharges (IED) on scalp EEG. We used high-density EEG to measure connectivity in large‐scale functional networks of patients with focal epilepsy (Temporal and Extratemporal Lobe Epilepsy, TLE and ETLE) and tested for network alterations during resting wakefulness without IEDs, compared to healthy controls. We measured global efficiency as a marker of integration within networks. Methods: We analysed 49 adult patients with focal epilepsy and 16 healthy subjects who underwent high-density-EEG and structural MRI. We estimated cortical activity using electric source analysis in 82 atlas-based cortical regions based on the individual MRI. We applied directed connectivity analysis (Partial Directed Coherence) on these sources and performed graph analysis: we computed the Global Efficiency on the whole brain and on each resting state network. We tested these features in different group of patients. Results: Compared to controls, efficiency was increased in both TLE and ETLE (p < 0.05). The somato-motor-network, the ventral-attention-network and the default-mode-network had a significantly increased efficiency (p < 0.05) in both TLE and ETLE as well as TLE with hippocampal sclerosis. Significance: During interictal scalp EEG epochs without IED, patients with focal epilepsy show brain functional connectivity alterations in the whole brain and in specific resting-state-networks. This higher integration reflects a chronic effect of pathological activity within these structures and complement previous work on altered information outflow. These findings could increase the diagnostic sensitivity of scalp EEG to identify epileptic activity in the absence of IED.http://www.sciencedirect.com/science/article/pii/S221315822030173XEpilepsyResting StateConnectivityNetwork integrationGlobal Efficiency |
| spellingShingle | Margherita Carboni Pia De Stefano Bernd J. Vorderwülbecke Sebastien Tourbier Emeline Mullier Maria Rubega Shahan Momjian Karl Schaller Patric Hagmann Margitta Seeck Christoph M. Michel Pieter van Mierlo Serge Vulliemoz Abnormal directed connectivity of resting state networks in focal epilepsy NeuroImage: Clinical Epilepsy Resting State Connectivity Network integration Global Efficiency |
| title | Abnormal directed connectivity of resting state networks in focal epilepsy |
| title_full | Abnormal directed connectivity of resting state networks in focal epilepsy |
| title_fullStr | Abnormal directed connectivity of resting state networks in focal epilepsy |
| title_full_unstemmed | Abnormal directed connectivity of resting state networks in focal epilepsy |
| title_short | Abnormal directed connectivity of resting state networks in focal epilepsy |
| title_sort | abnormal directed connectivity of resting state networks in focal epilepsy |
| topic | Epilepsy Resting State Connectivity Network integration Global Efficiency |
| url | http://www.sciencedirect.com/science/article/pii/S221315822030173X |
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